Gut microbiome and liver diseases
Symbiotic microbiota plays a crucial role in the education, development, and maintenance of the host immune system, significantly contributing to overall health. Through the gut-liver axis, the gut microbiota and liver have a bidirectional relationship that is becoming increasingly evident as more r...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co. Ltd.
2025-03-01
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| Series: | Fundamental Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667325824003650 |
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| _version_ | 1850208810543611904 |
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| author | Jun Xu Ning Chen Zhou Li Yulan Liu |
| author_facet | Jun Xu Ning Chen Zhou Li Yulan Liu |
| author_sort | Jun Xu |
| collection | DOAJ |
| description | Symbiotic microbiota plays a crucial role in the education, development, and maintenance of the host immune system, significantly contributing to overall health. Through the gut-liver axis, the gut microbiota and liver have a bidirectional relationship that is becoming increasingly evident as more research highlights the translocation of the gut microbiota and its metabolites. The focus of this narrative review is to examine and discuss the importance of the gut-liver axis and the enterohepatic barrier in maintaining overall health. Additionally, we emphasize the crucial role of the gut microbiome in liver diseases and explore potential therapeutic strategies for liver diseases by manipulating the microbiota. |
| format | Article |
| id | doaj-art-f2a6a69c20e941e4b7d92b9fc561e0f7 |
| institution | OA Journals |
| issn | 2667-3258 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | KeAi Communications Co. Ltd. |
| record_format | Article |
| series | Fundamental Research |
| spelling | doaj-art-f2a6a69c20e941e4b7d92b9fc561e0f72025-08-20T02:10:09ZengKeAi Communications Co. Ltd.Fundamental Research2667-32582025-03-015289090110.1016/j.fmre.2024.09.007Gut microbiome and liver diseasesJun Xu0Ning Chen1Zhou Li2Yulan Liu3Department of Gastroenterology, Peking University People's Hospital, Beijing 100044, China; Clinical Center of Immune-Mediated Digestive Diseases, Peking University People's Hospital, Beijing 100044, ChinaDepartment of Gastroenterology, Peking University People's Hospital, Beijing 100044, China; Clinical Center of Immune-Mediated Digestive Diseases, Peking University People's Hospital, Beijing 100044, ChinaBeijing Key Laboratory of Micro-nano Energy and Sensor, Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of Sciences, Beijing 101400, China; School of Nanoscience and Engineering, University of Chinese Academy of Sciences, Beijing 100049, China; Corresponding authors.Department of Gastroenterology, Peking University People's Hospital, Beijing 100044, China; Clinical Center of Immune-Mediated Digestive Diseases, Peking University People's Hospital, Beijing 100044, China; Corresponding authors.Symbiotic microbiota plays a crucial role in the education, development, and maintenance of the host immune system, significantly contributing to overall health. Through the gut-liver axis, the gut microbiota and liver have a bidirectional relationship that is becoming increasingly evident as more research highlights the translocation of the gut microbiota and its metabolites. The focus of this narrative review is to examine and discuss the importance of the gut-liver axis and the enterohepatic barrier in maintaining overall health. Additionally, we emphasize the crucial role of the gut microbiome in liver diseases and explore potential therapeutic strategies for liver diseases by manipulating the microbiota.http://www.sciencedirect.com/science/article/pii/S2667325824003650Gut-liver axisGut microbiomeEnterohepatic barrierLiver diseaseTherapeutic strategy |
| spellingShingle | Jun Xu Ning Chen Zhou Li Yulan Liu Gut microbiome and liver diseases Fundamental Research Gut-liver axis Gut microbiome Enterohepatic barrier Liver disease Therapeutic strategy |
| title | Gut microbiome and liver diseases |
| title_full | Gut microbiome and liver diseases |
| title_fullStr | Gut microbiome and liver diseases |
| title_full_unstemmed | Gut microbiome and liver diseases |
| title_short | Gut microbiome and liver diseases |
| title_sort | gut microbiome and liver diseases |
| topic | Gut-liver axis Gut microbiome Enterohepatic barrier Liver disease Therapeutic strategy |
| url | http://www.sciencedirect.com/science/article/pii/S2667325824003650 |
| work_keys_str_mv | AT junxu gutmicrobiomeandliverdiseases AT ningchen gutmicrobiomeandliverdiseases AT zhouli gutmicrobiomeandliverdiseases AT yulanliu gutmicrobiomeandliverdiseases |