Identification of genes associated with longevity in dogs: 9 candidate genes described in Cavalier King Charles Spaniel
In the past years, dogs have served as a convenient natural model organism for longevity due to their similarity with humans concerning not only their environment but also the diseases and complications occurring in older age. Since many dog breeds have significantly shorter lifespan than their clos...
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| Language: | English |
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Elsevier
2025-03-01
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| Series: | Veterinary and Animal Science |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2451943X24000875 |
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| author | Evžen Korec Lenka Ungrová Josef Kalvas Jiří Hejnar |
| author_facet | Evžen Korec Lenka Ungrová Josef Kalvas Jiří Hejnar |
| author_sort | Evžen Korec |
| collection | DOAJ |
| description | In the past years, dogs have served as a convenient natural model organism for longevity due to their similarity with humans concerning not only their environment but also the diseases and complications occurring in older age. Since many dog breeds have significantly shorter lifespan than their closely related breeds, identification of genes associated with longevity may help to elucidate its background and serve as a possible tool for selective breeding of long-living dogs. This genome-wide association study (GWAS) was undertaken to identify the candidate genes associated with longevity in Cavalier King Charles Spaniel individuals that have reached the age of more than 13 years. We described 15 SNPs localized in nine genes: B3GALNT1, NLRP1 like, PARP14, IQCJ-SCHIP1, COL9A1, COL19A1, SDHAF4, B3GAT2, and DIRC2 that are associated with longevity in purebred Cavalier King Charles Spaniels. These results are promising for future research and possible selective breeding of companion dogs with extended lifespan. |
| format | Article |
| id | doaj-art-f2a383bae1454befbbe2e09197d85fac |
| institution | OA Journals |
| issn | 2451-943X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Veterinary and Animal Science |
| spelling | doaj-art-f2a383bae1454befbbe2e09197d85fac2025-08-20T01:57:52ZengElsevierVeterinary and Animal Science2451-943X2025-03-012710042010.1016/j.vas.2024.100420Identification of genes associated with longevity in dogs: 9 candidate genes described in Cavalier King Charles SpanielEvžen Korec0Lenka Ungrová1Josef Kalvas2Jiří Hejnar3ZOO Tábor a.s., Dukelských Hrdinů 19, 170 00 Prague 7, Czech Republic; Corresponding author.ZOO Tábor a.s., Dukelských Hrdinů 19, 170 00 Prague 7, Czech Republic; Institute of Molecular Genetics of the Czech Academy of Sciences, Vídeňská 1083, 142 20 Prague 4, Czech RepublicZOO Tábor a.s., Dukelských Hrdinů 19, 170 00 Prague 7, Czech RepublicInstitute of Molecular Genetics of the Czech Academy of Sciences, Vídeňská 1083, 142 20 Prague 4, Czech RepublicIn the past years, dogs have served as a convenient natural model organism for longevity due to their similarity with humans concerning not only their environment but also the diseases and complications occurring in older age. Since many dog breeds have significantly shorter lifespan than their closely related breeds, identification of genes associated with longevity may help to elucidate its background and serve as a possible tool for selective breeding of long-living dogs. This genome-wide association study (GWAS) was undertaken to identify the candidate genes associated with longevity in Cavalier King Charles Spaniel individuals that have reached the age of more than 13 years. We described 15 SNPs localized in nine genes: B3GALNT1, NLRP1 like, PARP14, IQCJ-SCHIP1, COL9A1, COL19A1, SDHAF4, B3GAT2, and DIRC2 that are associated with longevity in purebred Cavalier King Charles Spaniels. These results are promising for future research and possible selective breeding of companion dogs with extended lifespan.http://www.sciencedirect.com/science/article/pii/S2451943X24000875Longevity-associated genesGWASCavalier King Charles Spaniel dogExtending lifespanLongevity testing |
| spellingShingle | Evžen Korec Lenka Ungrová Josef Kalvas Jiří Hejnar Identification of genes associated with longevity in dogs: 9 candidate genes described in Cavalier King Charles Spaniel Veterinary and Animal Science Longevity-associated genes GWAS Cavalier King Charles Spaniel dog Extending lifespan Longevity testing |
| title | Identification of genes associated with longevity in dogs: 9 candidate genes described in Cavalier King Charles Spaniel |
| title_full | Identification of genes associated with longevity in dogs: 9 candidate genes described in Cavalier King Charles Spaniel |
| title_fullStr | Identification of genes associated with longevity in dogs: 9 candidate genes described in Cavalier King Charles Spaniel |
| title_full_unstemmed | Identification of genes associated with longevity in dogs: 9 candidate genes described in Cavalier King Charles Spaniel |
| title_short | Identification of genes associated with longevity in dogs: 9 candidate genes described in Cavalier King Charles Spaniel |
| title_sort | identification of genes associated with longevity in dogs 9 candidate genes described in cavalier king charles spaniel |
| topic | Longevity-associated genes GWAS Cavalier King Charles Spaniel dog Extending lifespan Longevity testing |
| url | http://www.sciencedirect.com/science/article/pii/S2451943X24000875 |
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