Quantifying LAGA mutated mouse IgG2a monoclonal antibody with a rapid pepsin digestion enabled immunoaffinity LC/MS/MS assay

Quantifying LAGA mutated mouse IgG2a monoclonal antibody with a rapid pepsin digestion enabled immunoaffinity LC/MS/MS assay

A sensitive and specific bioanalytical method was required to measure the exposure of a LAGA-mutated surrogate mouse IgG2a monoclonal antibody in mouse plasma, but the lack of highly specific reagents for the LAGA mutant hindered the development of a ligand-binding assay. Equally problematic is that...

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Bibliographic Details
Main Authors: Linlin Dong, Susan Chen, Konstantin Piatkov, Dong Wei, Mark G. Qian
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:mAbs
Subjects:
Immunoaffinity enrichment
LC/MS/MS
monoclonal antibody
mouse plasma
pepsin
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2024.2379903
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