Amyloids in bladder cancer hijack cancer-related proteins and are positive correlated to tumor stage
Abstract Despite the current diagnostic and therapeutic approaches to bladder cancer being widely accepted, there have been few significant advancements in this field over the past decades. This underscores the necessity for a paradigm shift in the approach to bladder cancer. The role of amyloids in...
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Nature Portfolio
2025-02-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-025-88307-7 |
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| author | Diego Alem César X. García-Laviña Francisco Garagorry Dardo Centurión Joaquina Farias Hany Pazos-Espinosa María Noel Cuitiño-Mendiberry Carolina Villadóniga Susana Castro-Sowinski Martín Fló Federico Carrión Brenda Iglesias Kevin Madauss Lucía Canclini |
| author_facet | Diego Alem César X. García-Laviña Francisco Garagorry Dardo Centurión Joaquina Farias Hany Pazos-Espinosa María Noel Cuitiño-Mendiberry Carolina Villadóniga Susana Castro-Sowinski Martín Fló Federico Carrión Brenda Iglesias Kevin Madauss Lucía Canclini |
| author_sort | Diego Alem |
| collection | DOAJ |
| description | Abstract Despite the current diagnostic and therapeutic approaches to bladder cancer being widely accepted, there have been few significant advancements in this field over the past decades. This underscores the necessity for a paradigm shift in the approach to bladder cancer. The role of amyloids in cancer remains unclear despite their identification in several other pathologies. In this study, we present evidence of amyloids in bladder cancer, both in vitro and in vivo. In a murine model of bladder cancer, a positive correlation was observed between amyloids and tumor stage, indicating an association between amyloids and bladder cancer progression. Subsequently, the amyloid proteome of the RT4 non-invasive and HT1197 invasive bladder cancer cell lines was identified and included oncogenes, tumor suppressors, and highly expressed cancer-related proteins. It is proposed that amyloids function as structures that sequester key proteins. Therefore, amyloids should be considered in the study and diagnosis of bladder cancer. |
| format | Article |
| id | doaj-art-f297abd9c5d941abb15b1faf88438df1 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-f297abd9c5d941abb15b1faf88438df12025-02-09T12:36:07ZengNature PortfolioScientific Reports2045-23222025-02-0115111910.1038/s41598-025-88307-7Amyloids in bladder cancer hijack cancer-related proteins and are positive correlated to tumor stageDiego Alem0César X. García-Laviña1Francisco Garagorry2Dardo Centurión3Joaquina Farias4Hany Pazos-Espinosa5María Noel Cuitiño-Mendiberry6Carolina Villadóniga7Susana Castro-Sowinski8Martín Fló9Federico Carrión10Brenda Iglesias11Kevin Madauss12Lucía Canclini13Departamento de Genética, Instituto de Investigaciones Biológicas Clemente EstableSección Bioquímica, Facultad de Ciencias, Universidad de la RepúblicaCátedra de Anatomía Patológica, Hospital de Clínicas, Facultad de Medicina, Universidad de la RepúblicaCátedra de Anatomía Patológica, Hospital de Clínicas, Facultad de Medicina, Universidad de la RepúblicaEspacio de Biología Vegetal del Noreste, CENUR Noreste, Universidad de la RepúblicaDepartamento de Genética, Instituto de Investigaciones Biológicas Clemente EstableBioterio de roedores, Instituto de Investigaciones Biológicas Clemente EstableLaboratorio de Biocatalizadores y sus Aplicaciones, Facultad de Ciencias, Universidad de la RepúblicaDepartamento de Genética, Instituto de Investigaciones Biológicas Clemente EstableLaboratorio de Inmunovirología, Institut Pasteur de MontevideoLaboratorio de Inmunovirología, Institut Pasteur de MontevideoResearch Technologies, Research Operations and Externalization, GSK-R&DResearch Technologies, Research Operations and Externalization, GSK-R&DDepartamento de Genética, Instituto de Investigaciones Biológicas Clemente EstableAbstract Despite the current diagnostic and therapeutic approaches to bladder cancer being widely accepted, there have been few significant advancements in this field over the past decades. This underscores the necessity for a paradigm shift in the approach to bladder cancer. The role of amyloids in cancer remains unclear despite their identification in several other pathologies. In this study, we present evidence of amyloids in bladder cancer, both in vitro and in vivo. In a murine model of bladder cancer, a positive correlation was observed between amyloids and tumor stage, indicating an association between amyloids and bladder cancer progression. Subsequently, the amyloid proteome of the RT4 non-invasive and HT1197 invasive bladder cancer cell lines was identified and included oncogenes, tumor suppressors, and highly expressed cancer-related proteins. It is proposed that amyloids function as structures that sequester key proteins. Therefore, amyloids should be considered in the study and diagnosis of bladder cancer.https://doi.org/10.1038/s41598-025-88307-7 |
| spellingShingle | Diego Alem César X. García-Laviña Francisco Garagorry Dardo Centurión Joaquina Farias Hany Pazos-Espinosa María Noel Cuitiño-Mendiberry Carolina Villadóniga Susana Castro-Sowinski Martín Fló Federico Carrión Brenda Iglesias Kevin Madauss Lucía Canclini Amyloids in bladder cancer hijack cancer-related proteins and are positive correlated to tumor stage Scientific Reports |
| title | Amyloids in bladder cancer hijack cancer-related proteins and are positive correlated to tumor stage |
| title_full | Amyloids in bladder cancer hijack cancer-related proteins and are positive correlated to tumor stage |
| title_fullStr | Amyloids in bladder cancer hijack cancer-related proteins and are positive correlated to tumor stage |
| title_full_unstemmed | Amyloids in bladder cancer hijack cancer-related proteins and are positive correlated to tumor stage |
| title_short | Amyloids in bladder cancer hijack cancer-related proteins and are positive correlated to tumor stage |
| title_sort | amyloids in bladder cancer hijack cancer related proteins and are positive correlated to tumor stage |
| url | https://doi.org/10.1038/s41598-025-88307-7 |
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