Melanonychia Secondary to Long-Term Treatment with Hydroxycarbamide: An Essential Thrombocytosis Case

Hydroxycarbamide is used in the treatment of essential thrombocytosis and other myeloproliferative disorders. We report the case of a 63-year-old woman with essential thrombocytosis who had melanonychia after the long-term use of the hydroxycarbamide with a dose of 1000 mg/day. Two years after the i...

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Main Authors: Umit Yavuz Malkan, Gursel Gunes, Eylem Eliacik, Okan Yayar, Ibrahim Celalettin Haznedaroglu
Format: Article
Language:English
Published: Wiley 2015-01-01
Series:Case Reports in Hematology
Online Access:http://dx.doi.org/10.1155/2015/653178
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author Umit Yavuz Malkan
Gursel Gunes
Eylem Eliacik
Okan Yayar
Ibrahim Celalettin Haznedaroglu
author_facet Umit Yavuz Malkan
Gursel Gunes
Eylem Eliacik
Okan Yayar
Ibrahim Celalettin Haznedaroglu
author_sort Umit Yavuz Malkan
collection DOAJ
description Hydroxycarbamide is used in the treatment of essential thrombocytosis and other myeloproliferative disorders. We report the case of a 63-year-old woman with essential thrombocytosis who had melanonychia after the long-term use of the hydroxycarbamide with a dose of 1000 mg/day. Two years after the initiation of the hydroxycarbamide, our patient had pain on her toes and melanonychia on her nails. Hydroxycarbamide treatment was discontinued because of pain and she was given anagrelide treatment. The pathogenesis of melanonychia secondary to long-term hydroxycarbamide treatment is not yet well understood. Some investigators suggested that genetic factors, induction of melanocytes, and some changes in nail matrix could be the reason of hydroxycarbamide related melanonychia. Our patient has suffered color changes in her nails as well as pain that made us doubtful for a beginning of ulceration besides melanonychia. Maybe early clinical reaction of discontinuation of the drug has prevented more severe side effect like ulceration in our patient. Also side effect of hydroxycarbamide has developed more slowly in our patient compared to other patients in the mentioned study. To conclude, long-term hydroxycarbamide treatment can cause mucocutaneous side effects and more studies should be done in future in order to reveal the underlying mechanism.
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language English
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series Case Reports in Hematology
spelling doaj-art-f29455492e0a40d39aa0eec2b96b1e3d2025-02-03T05:53:41ZengWileyCase Reports in Hematology2090-65602090-65792015-01-01201510.1155/2015/653178653178Melanonychia Secondary to Long-Term Treatment with Hydroxycarbamide: An Essential Thrombocytosis CaseUmit Yavuz Malkan0Gursel Gunes1Eylem Eliacik2Okan Yayar3Ibrahim Celalettin Haznedaroglu4Department of Hematology, School of Medicine, Hacettepe University, 0100 Ankara, TurkeyDepartment of Hematology, School of Medicine, Hacettepe University, 0100 Ankara, TurkeyDepartment of Hematology, School of Medicine, Hacettepe University, 0100 Ankara, TurkeyDepartment of Hematology, School of Medicine, Hacettepe University, 0100 Ankara, TurkeyDepartment of Hematology, School of Medicine, Hacettepe University, 0100 Ankara, TurkeyHydroxycarbamide is used in the treatment of essential thrombocytosis and other myeloproliferative disorders. We report the case of a 63-year-old woman with essential thrombocytosis who had melanonychia after the long-term use of the hydroxycarbamide with a dose of 1000 mg/day. Two years after the initiation of the hydroxycarbamide, our patient had pain on her toes and melanonychia on her nails. Hydroxycarbamide treatment was discontinued because of pain and she was given anagrelide treatment. The pathogenesis of melanonychia secondary to long-term hydroxycarbamide treatment is not yet well understood. Some investigators suggested that genetic factors, induction of melanocytes, and some changes in nail matrix could be the reason of hydroxycarbamide related melanonychia. Our patient has suffered color changes in her nails as well as pain that made us doubtful for a beginning of ulceration besides melanonychia. Maybe early clinical reaction of discontinuation of the drug has prevented more severe side effect like ulceration in our patient. Also side effect of hydroxycarbamide has developed more slowly in our patient compared to other patients in the mentioned study. To conclude, long-term hydroxycarbamide treatment can cause mucocutaneous side effects and more studies should be done in future in order to reveal the underlying mechanism.http://dx.doi.org/10.1155/2015/653178
spellingShingle Umit Yavuz Malkan
Gursel Gunes
Eylem Eliacik
Okan Yayar
Ibrahim Celalettin Haznedaroglu
Melanonychia Secondary to Long-Term Treatment with Hydroxycarbamide: An Essential Thrombocytosis Case
Case Reports in Hematology
title Melanonychia Secondary to Long-Term Treatment with Hydroxycarbamide: An Essential Thrombocytosis Case
title_full Melanonychia Secondary to Long-Term Treatment with Hydroxycarbamide: An Essential Thrombocytosis Case
title_fullStr Melanonychia Secondary to Long-Term Treatment with Hydroxycarbamide: An Essential Thrombocytosis Case
title_full_unstemmed Melanonychia Secondary to Long-Term Treatment with Hydroxycarbamide: An Essential Thrombocytosis Case
title_short Melanonychia Secondary to Long-Term Treatment with Hydroxycarbamide: An Essential Thrombocytosis Case
title_sort melanonychia secondary to long term treatment with hydroxycarbamide an essential thrombocytosis case
url http://dx.doi.org/10.1155/2015/653178
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AT eylemeliacik melanonychiasecondarytolongtermtreatmentwithhydroxycarbamideanessentialthrombocytosiscase
AT okanyayar melanonychiasecondarytolongtermtreatmentwithhydroxycarbamideanessentialthrombocytosiscase
AT ibrahimcelalettinhaznedaroglu melanonychiasecondarytolongtermtreatmentwithhydroxycarbamideanessentialthrombocytosiscase