Alzheimer’s disease pathogenesis and risk factors
The article reviews the main hypothesis explaining the pathogenesis of Alzheimer’s disease in the formation and accumulation of P-amyloid plaques and neurofibrillary plexus in the brain as well as related theories on the mechanisms of copper and zinc dysregulation, excitotoxicity, cholinergic syste...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Vilnius University Press
2019-12-01
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| Series: | Neurologijos seminarai |
| Subjects: | |
| Online Access: | https://www.journals.vu.lt/neurologijos_seminarai/article/view/27766 |
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| _version_ | 1832593097549152256 |
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| author | A. Gerulytė L. Strumylaitė |
| author_facet | A. Gerulytė L. Strumylaitė |
| author_sort | A. Gerulytė |
| collection | DOAJ |
| description |
The article reviews the main hypothesis explaining the pathogenesis of Alzheimer’s disease in the formation and accumulation of P-amyloid plaques and neurofibrillary plexus in the brain as well as related theories on the mechanisms of copper and zinc dysregulation, excitotoxicity, cholinergic system dysfunction, and autophagy disorders. The main risk factors for Alzheimer’s disease (increased blood pressure, diabetes, reduced physical activity, brain trauma and the influence of some psychotropic medications) are also discussed.
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| format | Article |
| id | doaj-art-f293b55190df469cb2095c216bec305f |
| institution | Kabale University |
| issn | 1392-3064 2424-5917 |
| language | English |
| publishDate | 2019-12-01 |
| publisher | Vilnius University Press |
| record_format | Article |
| series | Neurologijos seminarai |
| spelling | doaj-art-f293b55190df469cb2095c216bec305f2025-01-20T18:22:53ZengVilnius University PressNeurologijos seminarai1392-30642424-59172019-12-01234(82)10.29014/ns.2019.25Alzheimer’s disease pathogenesis and risk factorsA. Gerulytė 0L. Strumylaitė 1Lithuanian University of Health SciencesLithuanian University of Health Sciences The article reviews the main hypothesis explaining the pathogenesis of Alzheimer’s disease in the formation and accumulation of P-amyloid plaques and neurofibrillary plexus in the brain as well as related theories on the mechanisms of copper and zinc dysregulation, excitotoxicity, cholinergic system dysfunction, and autophagy disorders. The main risk factors for Alzheimer’s disease (increased blood pressure, diabetes, reduced physical activity, brain trauma and the influence of some psychotropic medications) are also discussed. https://www.journals.vu.lt/neurologijos_seminarai/article/view/27766Alzheimer’s diseasedementiapathogenesisrisk factors |
| spellingShingle | A. Gerulytė L. Strumylaitė Alzheimer’s disease pathogenesis and risk factors Neurologijos seminarai Alzheimer’s disease dementia pathogenesis risk factors |
| title | Alzheimer’s disease pathogenesis and risk factors |
| title_full | Alzheimer’s disease pathogenesis and risk factors |
| title_fullStr | Alzheimer’s disease pathogenesis and risk factors |
| title_full_unstemmed | Alzheimer’s disease pathogenesis and risk factors |
| title_short | Alzheimer’s disease pathogenesis and risk factors |
| title_sort | alzheimer s disease pathogenesis and risk factors |
| topic | Alzheimer’s disease dementia pathogenesis risk factors |
| url | https://www.journals.vu.lt/neurologijos_seminarai/article/view/27766 |
| work_keys_str_mv | AT agerulyte alzheimersdiseasepathogenesisandriskfactors AT lstrumylaite alzheimersdiseasepathogenesisandriskfactors |