Exploring the Impact of Niacin Intake on Cardiovascular Outcomes: A Comprehensive Analysis Using NHANES Data (2003–2018)
Background: The relationship between cardiovascular outcomes and niacin consumption levels remains unclear. This study aimed to examine the correlation between niacin intake and the incidence of cardiovascular disease, as well as the mortality rates associated with cardiovascular...
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IMR Press
2024-11-01
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| Series: | Reviews in Cardiovascular Medicine |
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| Online Access: | https://www.imrpress.com/journal/RCM/25/11/10.31083/j.rcm2511410 |
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| author | Lishi Shao Aihua Zhi Manning Li Yang Zhang Shaohui Jiang Jun Zhang Ke Yang Enze Yang Xiankang Zhu Yuanou Cheng Yi Sun |
| author_facet | Lishi Shao Aihua Zhi Manning Li Yang Zhang Shaohui Jiang Jun Zhang Ke Yang Enze Yang Xiankang Zhu Yuanou Cheng Yi Sun |
| author_sort | Lishi Shao |
| collection | DOAJ |
| description | Background: The relationship between cardiovascular outcomes and niacin consumption levels remains unclear. This study aimed to examine the correlation between niacin intake and the incidence of cardiovascular disease, as well as the mortality rates associated with cardiovascular disease and other causes. Methods: From 2003 to 2018, we continually investigated updated information from the National Health and Nutrition Examination Survey. Based on the quartiles of niacin intake levels, four distinct categories of participants were established: Q1 (<14.646 mg), Q2 (14.646–21.302 mg), Q3 (21.302–30.401 mg), and Q4 (>30.401 mg). Baseline variable differences were assessed employing the Chi-Square and Student's t-tests. A weighted logistic regression with multiple variables was used to determine the association between niacin intake and cardiovascular disease prevalence. Hazard ratios (HRs) and 95% confidence intervals (CIs) for all-cause death and cardiovascular disease were determined utilising hazard regression models. Kaplan–Meier curves were used to compare survival probability between the high and low niacin intake groups, and dose-response linear relationships were evaluated with restricted cubic splines. Results: The cohort analysis included 80,312 participants for the assessment of niacin intake. Comparing the Q1 dataset to the Q4 dataset in the overall population, weighted Cox regression analysis showed a negative association with all-cause mortality (95% CI: 0.71–0.96, HR: 0.82) and mortality owing to cardiovascular disease (95% CI: 0.67–0.96, odds ratio (OR): 0.80). Sex-based subgroup analysis revealed a detrimental correlation between niacin use and overall mortality in females (Q4 cohort: 95% CI: 0.62–0.97, HR: 0.78) but not in males. Additionally, the Q3 (95% CI: 0.59–0.94, HR: 0.75) and Q4 (95% CI: 0.51–0.97, HR: 0.7) groups exhibited a negative association with female cardiovascular disease mortality compared to the Q1 group. Niacin intake was not significantly correlated with prevalence, all-cause mortality, or death from cardiovascular disease in males. Conclusions: Higher niacin consumption was correlated with a decreased risk of cardiovascular disease and death from all causes across the entire study population. Nevertheless, only females, and not males, exhibited a beneficial effect on mortality. |
| format | Article |
| id | doaj-art-f28fa83b8fb2462bbd320db2ed54f30e |
| institution | Kabale University |
| issn | 1530-6550 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Reviews in Cardiovascular Medicine |
| spelling | doaj-art-f28fa83b8fb2462bbd320db2ed54f30e2024-11-30T06:29:19ZengIMR PressReviews in Cardiovascular Medicine1530-65502024-11-01251141010.31083/j.rcm2511410S1530-6550(24)01534-5Exploring the Impact of Niacin Intake on Cardiovascular Outcomes: A Comprehensive Analysis Using NHANES Data (2003–2018)Lishi Shao0Aihua Zhi1Manning Li2Yang Zhang3Shaohui Jiang4Jun Zhang5Ke Yang6Enze Yang7Xiankang Zhu8Yuanou Cheng9Yi Sun10Department of Radiology, Fuwai Yunnan Cardiovascular Hospital, 650102 Kunming, Yunnan, ChinaDepartment of Radiology, Fuwai Yunnan Cardiovascular Hospital, 650102 Kunming, Yunnan, ChinaDepartment of Cardiac Surgery, Fuwai Yunnan Cardiovascular Hospital, 650102 Kunming, Yunnan, ChinaDepartment of Vascular Surgery, Kunming Children’s Hospital, 650034 Kunming, Yunnan, ChinaDepartment of Cardiac Surgery, Fuwai Yunnan Cardiovascular Hospital, 650102 Kunming, Yunnan, ChinaDepartment of Ultrasound, Fuwai Yunnan Cardiovascular Hospital, 650102 Kunming, Yunnan, ChinaDepartment of Anesthesiology, Fuwai Yunnan Cardiovascular Hospital, 650102 Kunming, Yunnan, ChinaDepartment of Cardiac Surgery, Fuwai Yunnan Cardiovascular Hospital, 650102 Kunming, Yunnan, ChinaDepartment of Cardiac Surgery, Fuwai Yunnan Cardiovascular Hospital, 650102 Kunming, Yunnan, ChinaDepartment of Cardiac Surgery, Fuwai Yunnan Cardiovascular Hospital, 650102 Kunming, Yunnan, ChinaDepartment of Cardiac Surgery, Fuwai Yunnan Cardiovascular Hospital, 650102 Kunming, Yunnan, ChinaBackground: The relationship between cardiovascular outcomes and niacin consumption levels remains unclear. This study aimed to examine the correlation between niacin intake and the incidence of cardiovascular disease, as well as the mortality rates associated with cardiovascular disease and other causes. Methods: From 2003 to 2018, we continually investigated updated information from the National Health and Nutrition Examination Survey. Based on the quartiles of niacin intake levels, four distinct categories of participants were established: Q1 (<14.646 mg), Q2 (14.646–21.302 mg), Q3 (21.302–30.401 mg), and Q4 (>30.401 mg). Baseline variable differences were assessed employing the Chi-Square and Student's t-tests. A weighted logistic regression with multiple variables was used to determine the association between niacin intake and cardiovascular disease prevalence. Hazard ratios (HRs) and 95% confidence intervals (CIs) for all-cause death and cardiovascular disease were determined utilising hazard regression models. Kaplan–Meier curves were used to compare survival probability between the high and low niacin intake groups, and dose-response linear relationships were evaluated with restricted cubic splines. Results: The cohort analysis included 80,312 participants for the assessment of niacin intake. Comparing the Q1 dataset to the Q4 dataset in the overall population, weighted Cox regression analysis showed a negative association with all-cause mortality (95% CI: 0.71–0.96, HR: 0.82) and mortality owing to cardiovascular disease (95% CI: 0.67–0.96, odds ratio (OR): 0.80). Sex-based subgroup analysis revealed a detrimental correlation between niacin use and overall mortality in females (Q4 cohort: 95% CI: 0.62–0.97, HR: 0.78) but not in males. Additionally, the Q3 (95% CI: 0.59–0.94, HR: 0.75) and Q4 (95% CI: 0.51–0.97, HR: 0.7) groups exhibited a negative association with female cardiovascular disease mortality compared to the Q1 group. Niacin intake was not significantly correlated with prevalence, all-cause mortality, or death from cardiovascular disease in males. Conclusions: Higher niacin consumption was correlated with a decreased risk of cardiovascular disease and death from all causes across the entire study population. Nevertheless, only females, and not males, exhibited a beneficial effect on mortality.https://www.imrpress.com/journal/RCM/25/11/10.31083/j.rcm2511410niacincvdall-causeprevalencemortalityfemale |
| spellingShingle | Lishi Shao Aihua Zhi Manning Li Yang Zhang Shaohui Jiang Jun Zhang Ke Yang Enze Yang Xiankang Zhu Yuanou Cheng Yi Sun Exploring the Impact of Niacin Intake on Cardiovascular Outcomes: A Comprehensive Analysis Using NHANES Data (2003–2018) Reviews in Cardiovascular Medicine niacin cvd all-cause prevalence mortality female |
| title | Exploring the Impact of Niacin Intake on Cardiovascular Outcomes: A Comprehensive Analysis Using NHANES Data (2003–2018) |
| title_full | Exploring the Impact of Niacin Intake on Cardiovascular Outcomes: A Comprehensive Analysis Using NHANES Data (2003–2018) |
| title_fullStr | Exploring the Impact of Niacin Intake on Cardiovascular Outcomes: A Comprehensive Analysis Using NHANES Data (2003–2018) |
| title_full_unstemmed | Exploring the Impact of Niacin Intake on Cardiovascular Outcomes: A Comprehensive Analysis Using NHANES Data (2003–2018) |
| title_short | Exploring the Impact of Niacin Intake on Cardiovascular Outcomes: A Comprehensive Analysis Using NHANES Data (2003–2018) |
| title_sort | exploring the impact of niacin intake on cardiovascular outcomes a comprehensive analysis using nhanes data 2003 2018 |
| topic | niacin cvd all-cause prevalence mortality female |
| url | https://www.imrpress.com/journal/RCM/25/11/10.31083/j.rcm2511410 |
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