Association between lipid accumulation product and the risk of colon cancer in adults: A population-based study.
<h4>Background</h4>The purpose of this study was to look into any potential connections between the occurrence of colon cancer and the condition of the body of lipid accumulation product (LAP) index.<h4>Methods</h4>Using data from the 2009-2018 National Health and Nutrition E...
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| Format: | Article |
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Public Library of Science (PLoS)
2025-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0317462 |
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| author | Renjie Guo Weiming Wei |
| author_facet | Renjie Guo Weiming Wei |
| author_sort | Renjie Guo |
| collection | DOAJ |
| description | <h4>Background</h4>The purpose of this study was to look into any potential connections between the occurrence of colon cancer and the condition of the body of lipid accumulation product (LAP) index.<h4>Methods</h4>Using data from the 2009-2018 National Health and Nutrition Examination Survey (NHANES), we performed a cross-sectional analysis with 24,592 individuals. Utilizing multivariate logistic regression modelling, the relationship between LAP levels and colon cancer risk was investigated. Subgroup analysis, trend test, interaction test, and stratified smoothed curve were also carried out.<h4>Results</h4>LAP levels and colon cancer risk were positively correlated after controlling for potential covariates (OR = 10.56, 95% CI: 2.40-46.53), the findings of trend tests are statistically significant. In particular groups, subgroup analysis revealed a positive connection between LAP levels and the risk of colon cancer. The association between LAP levels and colon cancer risk was shown to be M-shaped in the group under 60 years old, inverted V-shaped in the female and no-diabetes groups, and inverted L-shaped in the smoking and no-hypertensive groups, according to stratified smoothed curve fitting.<h4>Conclusions</h4>According to our findings, there is a strong correlation between LAP levels and the risk of colon cancer. |
| format | Article |
| id | doaj-art-f28ddddab3c343e39323bd93584bdc39 |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj-art-f28ddddab3c343e39323bd93584bdc392025-02-05T05:32:04ZengPublic Library of Science (PLoS)PLoS ONE1932-62032025-01-01201e031746210.1371/journal.pone.0317462Association between lipid accumulation product and the risk of colon cancer in adults: A population-based study.Renjie GuoWeiming Wei<h4>Background</h4>The purpose of this study was to look into any potential connections between the occurrence of colon cancer and the condition of the body of lipid accumulation product (LAP) index.<h4>Methods</h4>Using data from the 2009-2018 National Health and Nutrition Examination Survey (NHANES), we performed a cross-sectional analysis with 24,592 individuals. Utilizing multivariate logistic regression modelling, the relationship between LAP levels and colon cancer risk was investigated. Subgroup analysis, trend test, interaction test, and stratified smoothed curve were also carried out.<h4>Results</h4>LAP levels and colon cancer risk were positively correlated after controlling for potential covariates (OR = 10.56, 95% CI: 2.40-46.53), the findings of trend tests are statistically significant. In particular groups, subgroup analysis revealed a positive connection between LAP levels and the risk of colon cancer. The association between LAP levels and colon cancer risk was shown to be M-shaped in the group under 60 years old, inverted V-shaped in the female and no-diabetes groups, and inverted L-shaped in the smoking and no-hypertensive groups, according to stratified smoothed curve fitting.<h4>Conclusions</h4>According to our findings, there is a strong correlation between LAP levels and the risk of colon cancer.https://doi.org/10.1371/journal.pone.0317462 |
| spellingShingle | Renjie Guo Weiming Wei Association between lipid accumulation product and the risk of colon cancer in adults: A population-based study. PLoS ONE |
| title | Association between lipid accumulation product and the risk of colon cancer in adults: A population-based study. |
| title_full | Association between lipid accumulation product and the risk of colon cancer in adults: A population-based study. |
| title_fullStr | Association between lipid accumulation product and the risk of colon cancer in adults: A population-based study. |
| title_full_unstemmed | Association between lipid accumulation product and the risk of colon cancer in adults: A population-based study. |
| title_short | Association between lipid accumulation product and the risk of colon cancer in adults: A population-based study. |
| title_sort | association between lipid accumulation product and the risk of colon cancer in adults a population based study |
| url | https://doi.org/10.1371/journal.pone.0317462 |
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