The Role of Centella asiatica and Its Main Bioactive Compound, Asiatic Acid in Cardiac Remodeling: A Systematic Review of Animal Studies
Cardiac remodeling is a phenotype of heart failure characterized by a molecular, cellular, and interstitial change in the heart, which manifests in the change of size and function of the heart after specific insults with multiple mechanisms. Centella asiatica (CA) and its main bioactive triterpenoid...
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| Format: | Article |
| Language: | English |
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Cell and BioPharmaceutical Institute
2025-03-01
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| Series: | MCBS (Molecular and Cellular Biomedical Sciences) |
| Online Access: | https://cellbiopharm.com/ojs/index.php/MCBS/article/view/482 |
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| author | Muhamad Rizqy Fadhillah Wawaimuli Arozal Heri Wibowo Arleni Bustami Suci Widya Primadhani Nurul Gusti Khatimah Rizky Clarinta Putri Clara Riski Amanda Nur Azizah |
| author_facet | Muhamad Rizqy Fadhillah Wawaimuli Arozal Heri Wibowo Arleni Bustami Suci Widya Primadhani Nurul Gusti Khatimah Rizky Clarinta Putri Clara Riski Amanda Nur Azizah |
| author_sort | Muhamad Rizqy Fadhillah |
| collection | DOAJ |
| description | Cardiac remodeling is a phenotype of heart failure characterized by a molecular, cellular, and interstitial change in the heart, which manifests in the change of size and function of the heart after specific insults with multiple mechanisms. Centella asiatica (CA) and its main bioactive triterpenoid, asiatic acid (AA), pose antioxidant and anti-inflammatory effects. Still, no adequate clinical trials support the potency of CA and AA as anti-cardiac remodeling. Hence, this systematic review aims to provide an in-depth analysis of CA extract and AA in animal studies' prevention or therapy of cardiac remodeling. The search strategies were conducted based on preferred reporting Items for systematic reviews and meta-analysis (PRISMA) protocol through Pubmed, EMBASE, Scopus, and Web of Science using keywords as follows: “Centella asiatica” OR “Asiatic Acid” AND “Cardiac Remodeling” OR “Cardiac Hypertrophy” OR “Cardiac Fibrosis” along with their synonym. The data collected included hemodynamic parameters based on echocardiography, biomolecular tests such as quantitative polymerase chain reaction (qPCR), Western blotting, or biochemistry procedures. The paper quality was assessed using Systematic Review Centre for Laboratory Animal Experimentation (SYRCLE) risk of bias (RoB). The previous selected study has shown that CA and AA might prevent and cure cardiac remodeling by inhibiting various pathways and protein expressions through AMPKα, NOX2/4, PI3K/Akt/mTOR, p70S6K, YAP/TAZ, and IL-1β, IL-6, and IL-18 cytokines. CA and AA, thus, exhibit cardioprotective effects in the animal model, which need to be confirmed in the clinical trials on humans.
Keywords: cardiac remodeling, cardiac hypertrophy, cardiac fibrosis, Centella asiatica, asiatic acid |
| format | Article |
| id | doaj-art-f28bcdff44fc499d9f008992d61583f9 |
| institution | OA Journals |
| issn | 2527-4384 2527-3442 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Cell and BioPharmaceutical Institute |
| record_format | Article |
| series | MCBS (Molecular and Cellular Biomedical Sciences) |
| spelling | doaj-art-f28bcdff44fc499d9f008992d61583f92025-08-20T02:17:46ZengCell and BioPharmaceutical InstituteMCBS (Molecular and Cellular Biomedical Sciences)2527-43842527-34422025-03-019111210.21705/mcbs.v9i1.482147The Role of Centella asiatica and Its Main Bioactive Compound, Asiatic Acid in Cardiac Remodeling: A Systematic Review of Animal StudiesMuhamad Rizqy Fadhillah0Wawaimuli Arozal1Heri Wibowo2Arleni Bustami3Suci Widya Primadhani4Nurul Gusti Khatimah5Rizky Clarinta Putri6Clara Riski Amanda7Nur Azizah8Master’s Programme in Biomedical Science, Faculty of Medicine, Universitas Indonesia, JakartaDepartement of Pharmacology and Therapeutic, Faculty of Medicine, Universitas Indonesia, JakartaIntegrated Laboratory, Faculty of Medicine, Universitas Indonesia, JakartaIntegrated Laboratory, Faculty of Medicine, Universitas Indonesia, JakartaPublic Cileungsi Regional Hospital, CileungsiMaster’s Programme in Biomedical Science, Faculty of Medicine, Universitas Indonesia, JakartaMaster’s Programme in Biomedical Science, Faculty of Medicine, Universitas Indonesia, JakartaMaster’s Programme in Biomedical Science, Faculty of Medicine, Universitas Indonesia, JakartaMaster’s Programme in Biomedical Science, Faculty of Medicine, Universitas Indonesia, JakartaCardiac remodeling is a phenotype of heart failure characterized by a molecular, cellular, and interstitial change in the heart, which manifests in the change of size and function of the heart after specific insults with multiple mechanisms. Centella asiatica (CA) and its main bioactive triterpenoid, asiatic acid (AA), pose antioxidant and anti-inflammatory effects. Still, no adequate clinical trials support the potency of CA and AA as anti-cardiac remodeling. Hence, this systematic review aims to provide an in-depth analysis of CA extract and AA in animal studies' prevention or therapy of cardiac remodeling. The search strategies were conducted based on preferred reporting Items for systematic reviews and meta-analysis (PRISMA) protocol through Pubmed, EMBASE, Scopus, and Web of Science using keywords as follows: “Centella asiatica” OR “Asiatic Acid” AND “Cardiac Remodeling” OR “Cardiac Hypertrophy” OR “Cardiac Fibrosis” along with their synonym. The data collected included hemodynamic parameters based on echocardiography, biomolecular tests such as quantitative polymerase chain reaction (qPCR), Western blotting, or biochemistry procedures. The paper quality was assessed using Systematic Review Centre for Laboratory Animal Experimentation (SYRCLE) risk of bias (RoB). The previous selected study has shown that CA and AA might prevent and cure cardiac remodeling by inhibiting various pathways and protein expressions through AMPKα, NOX2/4, PI3K/Akt/mTOR, p70S6K, YAP/TAZ, and IL-1β, IL-6, and IL-18 cytokines. CA and AA, thus, exhibit cardioprotective effects in the animal model, which need to be confirmed in the clinical trials on humans. Keywords: cardiac remodeling, cardiac hypertrophy, cardiac fibrosis, Centella asiatica, asiatic acidhttps://cellbiopharm.com/ojs/index.php/MCBS/article/view/482 |
| spellingShingle | Muhamad Rizqy Fadhillah Wawaimuli Arozal Heri Wibowo Arleni Bustami Suci Widya Primadhani Nurul Gusti Khatimah Rizky Clarinta Putri Clara Riski Amanda Nur Azizah The Role of Centella asiatica and Its Main Bioactive Compound, Asiatic Acid in Cardiac Remodeling: A Systematic Review of Animal Studies MCBS (Molecular and Cellular Biomedical Sciences) |
| title | The Role of Centella asiatica and Its Main Bioactive Compound, Asiatic Acid in Cardiac Remodeling: A Systematic Review of Animal Studies |
| title_full | The Role of Centella asiatica and Its Main Bioactive Compound, Asiatic Acid in Cardiac Remodeling: A Systematic Review of Animal Studies |
| title_fullStr | The Role of Centella asiatica and Its Main Bioactive Compound, Asiatic Acid in Cardiac Remodeling: A Systematic Review of Animal Studies |
| title_full_unstemmed | The Role of Centella asiatica and Its Main Bioactive Compound, Asiatic Acid in Cardiac Remodeling: A Systematic Review of Animal Studies |
| title_short | The Role of Centella asiatica and Its Main Bioactive Compound, Asiatic Acid in Cardiac Remodeling: A Systematic Review of Animal Studies |
| title_sort | role of centella asiatica and its main bioactive compound asiatic acid in cardiac remodeling a systematic review of animal studies |
| url | https://cellbiopharm.com/ojs/index.php/MCBS/article/view/482 |
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