Vitamin Bs as Potent Anticancer Agents through MMP-2/9 Regulation
In recent years, the role of coenzymes, particularly those from the vitamin B group in modulating the activity of metalloenzymes has garnered significant attention in cancer treatment strategies. Metalloenzymes play pivotal roles in various cellular processes, including DNA repair, cell signaling, a...
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IMR Press
2025-01-01
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| Series: | Frontiers in Bioscience-Landmark |
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| Online Access: | https://www.imrpress.com/journal/FBL/30/1/10.31083/FBL24072 |
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| author | Ha Vy Thi Vo Namdoo Kim Hyuck Jin Lee |
| author_facet | Ha Vy Thi Vo Namdoo Kim Hyuck Jin Lee |
| author_sort | Ha Vy Thi Vo |
| collection | DOAJ |
| description | In recent years, the role of coenzymes, particularly those from the vitamin B group in modulating the activity of metalloenzymes has garnered significant attention in cancer treatment strategies. Metalloenzymes play pivotal roles in various cellular processes, including DNA repair, cell signaling, and metabolism, making them promising targets for cancer therapy. This review explores the complex interplay between coenzymes, specifically vitamin Bs, and metalloenzymes in cancer pathogenesis and treatment. Vitamins are an indispensable part of daily life, essential for optimal health and well-being. Beyond their recognized roles as essential nutrients, vitamins have increasingly garnered attention for their multifaceted functions within the machinery of cellular processes. In particular, vitamin Bs have emerged as a pivotal regulator within this intricate network, exerting profound effects on the functionality of metalloenzymes. Their ability to modulate metalloenzymes involved in crucial cellular pathways implicated in cancer progression presents a compelling avenue for therapeutic intervention. Key findings indicate that vitamin Bs can influence the activity and expression of metalloenzymes, thereby affecting processes such as DNA repair and cell signaling, which are critical in cancer development and progression. Understanding the mechanisms by which these coenzymes regulate metalloenzymes holds great promise for developing novel anticancer strategies. This review summarizes current knowledge on the interactions between vitamin Bs and metalloenzymes, highlighting their potential as anticancer agents and paving the way for innovative, cell-targeted cancer treatments. |
| format | Article |
| id | doaj-art-f26985eb9872495b98b2a72d2a94607b |
| institution | Kabale University |
| issn | 2768-6701 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Frontiers in Bioscience-Landmark |
| spelling | doaj-art-f26985eb9872495b98b2a72d2a94607b2025-01-25T08:55:52ZengIMR PressFrontiers in Bioscience-Landmark2768-67012025-01-013012407210.31083/FBL24072S2768-6701(24)01475-8Vitamin Bs as Potent Anticancer Agents through MMP-2/9 RegulationHa Vy Thi Vo0Namdoo Kim1Hyuck Jin Lee2Department of Chemistry Education, Kongju National University, 32588 Gongju, Chungcheongnam-do, Republic of KoreaDepartment of Chemistry, Kongju National University, 32588 Gongju, Chungcheongnam-do, Republic of KoreaDepartment of Chemistry Education, Kongju National University, 32588 Gongju, Chungcheongnam-do, Republic of KoreaIn recent years, the role of coenzymes, particularly those from the vitamin B group in modulating the activity of metalloenzymes has garnered significant attention in cancer treatment strategies. Metalloenzymes play pivotal roles in various cellular processes, including DNA repair, cell signaling, and metabolism, making them promising targets for cancer therapy. This review explores the complex interplay between coenzymes, specifically vitamin Bs, and metalloenzymes in cancer pathogenesis and treatment. Vitamins are an indispensable part of daily life, essential for optimal health and well-being. Beyond their recognized roles as essential nutrients, vitamins have increasingly garnered attention for their multifaceted functions within the machinery of cellular processes. In particular, vitamin Bs have emerged as a pivotal regulator within this intricate network, exerting profound effects on the functionality of metalloenzymes. Their ability to modulate metalloenzymes involved in crucial cellular pathways implicated in cancer progression presents a compelling avenue for therapeutic intervention. Key findings indicate that vitamin Bs can influence the activity and expression of metalloenzymes, thereby affecting processes such as DNA repair and cell signaling, which are critical in cancer development and progression. Understanding the mechanisms by which these coenzymes regulate metalloenzymes holds great promise for developing novel anticancer strategies. This review summarizes current knowledge on the interactions between vitamin Bs and metalloenzymes, highlighting their potential as anticancer agents and paving the way for innovative, cell-targeted cancer treatments.https://www.imrpress.com/journal/FBL/30/1/10.31083/FBL24072cancermatrix metalloproteinasescoenzymesmetalloenzyemsnatural products |
| spellingShingle | Ha Vy Thi Vo Namdoo Kim Hyuck Jin Lee Vitamin Bs as Potent Anticancer Agents through MMP-2/9 Regulation Frontiers in Bioscience-Landmark cancer matrix metalloproteinases coenzymes metalloenzyems natural products |
| title | Vitamin Bs as Potent Anticancer Agents through MMP-2/9 Regulation |
| title_full | Vitamin Bs as Potent Anticancer Agents through MMP-2/9 Regulation |
| title_fullStr | Vitamin Bs as Potent Anticancer Agents through MMP-2/9 Regulation |
| title_full_unstemmed | Vitamin Bs as Potent Anticancer Agents through MMP-2/9 Regulation |
| title_short | Vitamin Bs as Potent Anticancer Agents through MMP-2/9 Regulation |
| title_sort | vitamin bs as potent anticancer agents through mmp 2 9 regulation |
| topic | cancer matrix metalloproteinases coenzymes metalloenzyems natural products |
| url | https://www.imrpress.com/journal/FBL/30/1/10.31083/FBL24072 |
| work_keys_str_mv | AT havythivo vitaminbsaspotentanticanceragentsthroughmmp29regulation AT namdookim vitaminbsaspotentanticanceragentsthroughmmp29regulation AT hyuckjinlee vitaminbsaspotentanticanceragentsthroughmmp29regulation |