Impact of bariatric surgery on vitamin D metabolism and micronutrient deficiencies in severe obesity
Objective: This study aimed to investigate the impact of bariatric surgery on vitamin D metabolism and associated micronutrient deficiencies in individuals with obesity, emphasizing the prevalence of vitamin D deficiency in patients with severe obesity—a persistent concern after significant weight l...
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Elsevier
2025-06-01
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| Series: | Medicine in Drug Discovery |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590098625000041 |
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| author | Letícia de Oliveira Souza Bratti Bruno Fonseca Nunes Daphany Marah Gorges Emerita Quintina de Andrade Moura Ana Carolina Rabello de Moraes Fabíola Branco Filippin-Monteiro |
| author_facet | Letícia de Oliveira Souza Bratti Bruno Fonseca Nunes Daphany Marah Gorges Emerita Quintina de Andrade Moura Ana Carolina Rabello de Moraes Fabíola Branco Filippin-Monteiro |
| author_sort | Letícia de Oliveira Souza Bratti |
| collection | DOAJ |
| description | Objective: This study aimed to investigate the impact of bariatric surgery on vitamin D metabolism and associated micronutrient deficiencies in individuals with obesity, emphasizing the prevalence of vitamin D deficiency in patients with severe obesity—a persistent concern after significant weight loss. Methods: A comprehensive analysis of serum levels of 25(OH)D, parathyroid hormone (PTH), and calcium was conducted in patients with obesity before and after bariatric surgery, with a six-month follow-up. Medication usage was examined, and outcomes between different surgical techniques were compared. Results: Notable metabolic improvements, linked to reduced BMI and diminished medication reliance post-surgery, were observed. Sleeve gastrectomy (SG) demonstrated potential advantages in preventing micronutrient deficiencies. Many patients had preoperative vitamin D deficiency and elevated PTH levels. Correlation analysis revealed that among those with preoperative PTH levels exceeding 70 pg/mL, higher PTH levels were associated with lower weight loss after six months. No significant correlation was found for vitamin D. Conclusion: This study underscores the importance of critically assessing bone health in bariatric surgery candidates, emphasizing the need for meticulous preoperative evaluation and postoperative monitoring, particularly in cases of secondary hyperparathyroidism. These considerations are pivotal for optimizing the long-term well-being of bariatric surgery patients. |
| format | Article |
| id | doaj-art-f265348ad7f8462aacb0c6f514b202e3 |
| institution | OA Journals |
| issn | 2590-0986 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Medicine in Drug Discovery |
| spelling | doaj-art-f265348ad7f8462aacb0c6f514b202e32025-08-20T02:04:43ZengElsevierMedicine in Drug Discovery2590-09862025-06-012610020710.1016/j.medidd.2025.100207Impact of bariatric surgery on vitamin D metabolism and micronutrient deficiencies in severe obesityLetícia de Oliveira Souza Bratti0Bruno Fonseca Nunes1Daphany Marah Gorges2Emerita Quintina de Andrade Moura3Ana Carolina Rabello de Moraes4Fabíola Branco Filippin-Monteiro5Programa de Pós-Gaduação em Farmácia, Centro de Ciências da Saúde, Universidade Federal de Santa Catarina, Florianópolis, SC 88040900, BrazilDepartamento de Análises Clínicas, Centro de Ciências da Saúde, Universidade Federal de Santa Catarina, Florianópolis, SC 88040900, BrazilDepartamento de Análises Clínicas, Centro de Ciências da Saúde, Universidade Federal de Santa Catarina, Florianópolis, SC 88040900, BrazilHospital Universitário - Laboratório de Análises Clínicas, Universidade Federal de Santa Catarina, Florianópolis, SC 88040900, BrazilDepartamento de Análises Clínicas, Centro de Ciências da Saúde, Universidade Federal de Santa Catarina, Florianópolis, SC 88040900, BrazilDepartamento de Análises Clínicas, Centro de Ciências da Saúde, Universidade Federal de Santa Catarina, Florianópolis, SC 88040900, Brazil; Corresponding author at: Campus Universitário, Universidade Federal de Santa Catarina, Trindade, 88040900 Florianópolis, SC, Brasil.Objective: This study aimed to investigate the impact of bariatric surgery on vitamin D metabolism and associated micronutrient deficiencies in individuals with obesity, emphasizing the prevalence of vitamin D deficiency in patients with severe obesity—a persistent concern after significant weight loss. Methods: A comprehensive analysis of serum levels of 25(OH)D, parathyroid hormone (PTH), and calcium was conducted in patients with obesity before and after bariatric surgery, with a six-month follow-up. Medication usage was examined, and outcomes between different surgical techniques were compared. Results: Notable metabolic improvements, linked to reduced BMI and diminished medication reliance post-surgery, were observed. Sleeve gastrectomy (SG) demonstrated potential advantages in preventing micronutrient deficiencies. Many patients had preoperative vitamin D deficiency and elevated PTH levels. Correlation analysis revealed that among those with preoperative PTH levels exceeding 70 pg/mL, higher PTH levels were associated with lower weight loss after six months. No significant correlation was found for vitamin D. Conclusion: This study underscores the importance of critically assessing bone health in bariatric surgery candidates, emphasizing the need for meticulous preoperative evaluation and postoperative monitoring, particularly in cases of secondary hyperparathyroidism. These considerations are pivotal for optimizing the long-term well-being of bariatric surgery patients.http://www.sciencedirect.com/science/article/pii/S2590098625000041Bariatric surgeryVitamin DHyperparathyroidismCalciumOsteoporosis and fracture risk |
| spellingShingle | Letícia de Oliveira Souza Bratti Bruno Fonseca Nunes Daphany Marah Gorges Emerita Quintina de Andrade Moura Ana Carolina Rabello de Moraes Fabíola Branco Filippin-Monteiro Impact of bariatric surgery on vitamin D metabolism and micronutrient deficiencies in severe obesity Medicine in Drug Discovery Bariatric surgery Vitamin D Hyperparathyroidism Calcium Osteoporosis and fracture risk |
| title | Impact of bariatric surgery on vitamin D metabolism and micronutrient deficiencies in severe obesity |
| title_full | Impact of bariatric surgery on vitamin D metabolism and micronutrient deficiencies in severe obesity |
| title_fullStr | Impact of bariatric surgery on vitamin D metabolism and micronutrient deficiencies in severe obesity |
| title_full_unstemmed | Impact of bariatric surgery on vitamin D metabolism and micronutrient deficiencies in severe obesity |
| title_short | Impact of bariatric surgery on vitamin D metabolism and micronutrient deficiencies in severe obesity |
| title_sort | impact of bariatric surgery on vitamin d metabolism and micronutrient deficiencies in severe obesity |
| topic | Bariatric surgery Vitamin D Hyperparathyroidism Calcium Osteoporosis and fracture risk |
| url | http://www.sciencedirect.com/science/article/pii/S2590098625000041 |
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