Oral Microbiome Research in Biopsy Samples of Oral Potentially Malignant Disorders and Oral Squamous Cell Carcinoma and Its Challenges
This study aims to evaluate the potential benefits and challenges of integrating oral microbiome research into the clinical management of oral potentially malignant disorders (OPMD) and oral squamous cell carcinoma (OSCC). The oral microbiome has gained significant attention for its role in the path...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-12-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/14/23/11405 |
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| author | Bruno Špiljak Petar Ozretić Ana Andabak Rogulj Božana Lončar Brzak Vlaho Brailo Marija Škerlj Danica Vidović Juras |
| author_facet | Bruno Špiljak Petar Ozretić Ana Andabak Rogulj Božana Lončar Brzak Vlaho Brailo Marija Škerlj Danica Vidović Juras |
| author_sort | Bruno Špiljak |
| collection | DOAJ |
| description | This study aims to evaluate the potential benefits and challenges of integrating oral microbiome research into the clinical management of oral potentially malignant disorders (OPMD) and oral squamous cell carcinoma (OSCC). The oral microbiome has gained significant attention for its role in the pathogenesis and progression of these conditions, with emerging evidence suggesting its value as a diagnostic and prognostic tool. By critically analyzing current evidence and methodological considerations, this manuscript examines whether microbiome analysis in biopsy samples can aid in the early detection, prognosis, and management of OPMD and OSCC. The complexity and dynamic nature of the oral microbiome require a multifaceted approach to fully understand its clinical utility. Based on this review, we conclude that studying the oral microbiome in this context holds significant promise but also faces notable challenges, including methodological variability and the need for standardization. Ultimately, this manuscript addresses the question, “Should such research be undertaken, given the intricate interactions of various factors and the inherent obstacles involved?”, and also emphasizes the importance of further research to optimize clinical applications and improve patient outcomes. |
| format | Article |
| id | doaj-art-f25bb67bb45e4312aeee540640ee1ab0 |
| institution | OA Journals |
| issn | 2076-3417 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj-art-f25bb67bb45e4312aeee540640ee1ab02025-08-20T01:55:41ZengMDPI AGApplied Sciences2076-34172024-12-0114231140510.3390/app142311405Oral Microbiome Research in Biopsy Samples of Oral Potentially Malignant Disorders and Oral Squamous Cell Carcinoma and Its ChallengesBruno Špiljak0Petar Ozretić1Ana Andabak Rogulj2Božana Lončar Brzak3Vlaho Brailo4Marija Škerlj5Danica Vidović Juras6Department of Oral Medicine, University of Zagreb School of Dental Medicine, 10000 Zagreb, CroatiaLaboratory for Hereditary Cancer, Division of Molecular Medicine, Ruđer Bošković Institute, 10000 Zagreb, CroatiaDepartment of Oral Medicine, University of Zagreb School of Dental Medicine, 10000 Zagreb, CroatiaDepartment of Oral Medicine, University of Zagreb School of Dental Medicine, 10000 Zagreb, CroatiaDepartment of Oral Medicine, University of Zagreb School of Dental Medicine, 10000 Zagreb, CroatiaOncological Cytology Department, Ljudevit Jurak Clinical Department of Pathology and Cytology, Sestre Milosrdnice University Hospital Center Zagreb, 10000 Zagreb, CroatiaDepartment of Oral Medicine, University of Zagreb School of Dental Medicine, 10000 Zagreb, CroatiaThis study aims to evaluate the potential benefits and challenges of integrating oral microbiome research into the clinical management of oral potentially malignant disorders (OPMD) and oral squamous cell carcinoma (OSCC). The oral microbiome has gained significant attention for its role in the pathogenesis and progression of these conditions, with emerging evidence suggesting its value as a diagnostic and prognostic tool. By critically analyzing current evidence and methodological considerations, this manuscript examines whether microbiome analysis in biopsy samples can aid in the early detection, prognosis, and management of OPMD and OSCC. The complexity and dynamic nature of the oral microbiome require a multifaceted approach to fully understand its clinical utility. Based on this review, we conclude that studying the oral microbiome in this context holds significant promise but also faces notable challenges, including methodological variability and the need for standardization. Ultimately, this manuscript addresses the question, “Should such research be undertaken, given the intricate interactions of various factors and the inherent obstacles involved?”, and also emphasizes the importance of further research to optimize clinical applications and improve patient outcomes.https://www.mdpi.com/2076-3417/14/23/11405oral microbiomeoral potentially malignant disordersoral squamous cell carcinomainfluencing factorsobstacles |
| spellingShingle | Bruno Špiljak Petar Ozretić Ana Andabak Rogulj Božana Lončar Brzak Vlaho Brailo Marija Škerlj Danica Vidović Juras Oral Microbiome Research in Biopsy Samples of Oral Potentially Malignant Disorders and Oral Squamous Cell Carcinoma and Its Challenges Applied Sciences oral microbiome oral potentially malignant disorders oral squamous cell carcinoma influencing factors obstacles |
| title | Oral Microbiome Research in Biopsy Samples of Oral Potentially Malignant Disorders and Oral Squamous Cell Carcinoma and Its Challenges |
| title_full | Oral Microbiome Research in Biopsy Samples of Oral Potentially Malignant Disorders and Oral Squamous Cell Carcinoma and Its Challenges |
| title_fullStr | Oral Microbiome Research in Biopsy Samples of Oral Potentially Malignant Disorders and Oral Squamous Cell Carcinoma and Its Challenges |
| title_full_unstemmed | Oral Microbiome Research in Biopsy Samples of Oral Potentially Malignant Disorders and Oral Squamous Cell Carcinoma and Its Challenges |
| title_short | Oral Microbiome Research in Biopsy Samples of Oral Potentially Malignant Disorders and Oral Squamous Cell Carcinoma and Its Challenges |
| title_sort | oral microbiome research in biopsy samples of oral potentially malignant disorders and oral squamous cell carcinoma and its challenges |
| topic | oral microbiome oral potentially malignant disorders oral squamous cell carcinoma influencing factors obstacles |
| url | https://www.mdpi.com/2076-3417/14/23/11405 |
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