Abnormal Functional Connectivity of Ventral Anterior Insula in Asthmatic Patients with Depression
Objective. To explore the underlying mechanism of depression in asthmatic patients, the ReHo in the insula and its FC was used to probe the differences between depressed asthmatic (DA) and nondepressed asthmatic (NDA) patients. Methods. 18 DA patients, 24 NDA patients, and 60 healthy controls (HCs)...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2017/7838035 |
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| author | Yuqun Zhang Yuan Yang Rongrong Bian Yingying Yin Zhenghua Hou Yingying Yue Zhi Xu Yonggui Yuan |
| author_facet | Yuqun Zhang Yuan Yang Rongrong Bian Yingying Yin Zhenghua Hou Yingying Yue Zhi Xu Yonggui Yuan |
| author_sort | Yuqun Zhang |
| collection | DOAJ |
| description | Objective. To explore the underlying mechanism of depression in asthmatic patients, the ReHo in the insula and its FC was used to probe the differences between depressed asthmatic (DA) and nondepressed asthmatic (NDA) patients. Methods. 18 DA patients, 24 NDA patients, and 60 healthy controls (HCs) received resting-state fMRI scan, severity of depression, and asthma control assessment. Results. DA patients showed increased FC between the left ventral anterior insula (vAI) and the left middle temporal gyrus compared with both NDA and HC groups. In addition, compared with HCs, the DA and NDA patients both exhibited increased FC between the left vAI and the right anterior cingulate cortex (ACC), decreased FC between the left vAI and the bilateral parietal lobe, and increased FC between the right vAI and the left putamen and the right caudate, respectively. Furthermore, the increased FC between the left vAI and the right ACC could differentiate HCs from both DA and NDA patients, and the increased FC between the right vAI and both the left putamen and the right caudate could separate NDA patients from HCs. Conclusions. This study confirmed that abnormal vAI FC may be involved in the neuropathology of depression in asthma. The increased FC between the left vAI and the left MTG could distinguish DA from the NDA and HC groups. |
| format | Article |
| id | doaj-art-f25b332850b34925bb234c67c74d96a8 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-f25b332850b34925bb234c67c74d96a82025-02-03T05:58:19ZengWileyNeural Plasticity2090-59041687-54432017-01-01201710.1155/2017/78380357838035Abnormal Functional Connectivity of Ventral Anterior Insula in Asthmatic Patients with DepressionYuqun Zhang0Yuan Yang1Rongrong Bian2Yingying Yin3Zhenghua Hou4Yingying Yue5Zhi Xu6Yonggui Yuan7Department of Psychosomatics and Psychiatry, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, ChinaDepartment of Respiration, Zhongda Hospital, Southeast University, Nanjing, ChinaDepartment of Psychosomatics and Psychiatry, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, ChinaDepartment of Psychosomatics and Psychiatry, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, ChinaDepartment of Psychosomatics and Psychiatry, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, ChinaDepartment of Psychosomatics and Psychiatry, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, ChinaDepartment of Psychosomatics and Psychiatry, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, ChinaDepartment of Psychosomatics and Psychiatry, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, ChinaObjective. To explore the underlying mechanism of depression in asthmatic patients, the ReHo in the insula and its FC was used to probe the differences between depressed asthmatic (DA) and nondepressed asthmatic (NDA) patients. Methods. 18 DA patients, 24 NDA patients, and 60 healthy controls (HCs) received resting-state fMRI scan, severity of depression, and asthma control assessment. Results. DA patients showed increased FC between the left ventral anterior insula (vAI) and the left middle temporal gyrus compared with both NDA and HC groups. In addition, compared with HCs, the DA and NDA patients both exhibited increased FC between the left vAI and the right anterior cingulate cortex (ACC), decreased FC between the left vAI and the bilateral parietal lobe, and increased FC between the right vAI and the left putamen and the right caudate, respectively. Furthermore, the increased FC between the left vAI and the right ACC could differentiate HCs from both DA and NDA patients, and the increased FC between the right vAI and both the left putamen and the right caudate could separate NDA patients from HCs. Conclusions. This study confirmed that abnormal vAI FC may be involved in the neuropathology of depression in asthma. The increased FC between the left vAI and the left MTG could distinguish DA from the NDA and HC groups.http://dx.doi.org/10.1155/2017/7838035 |
| spellingShingle | Yuqun Zhang Yuan Yang Rongrong Bian Yingying Yin Zhenghua Hou Yingying Yue Zhi Xu Yonggui Yuan Abnormal Functional Connectivity of Ventral Anterior Insula in Asthmatic Patients with Depression Neural Plasticity |
| title | Abnormal Functional Connectivity of Ventral Anterior Insula in Asthmatic Patients with Depression |
| title_full | Abnormal Functional Connectivity of Ventral Anterior Insula in Asthmatic Patients with Depression |
| title_fullStr | Abnormal Functional Connectivity of Ventral Anterior Insula in Asthmatic Patients with Depression |
| title_full_unstemmed | Abnormal Functional Connectivity of Ventral Anterior Insula in Asthmatic Patients with Depression |
| title_short | Abnormal Functional Connectivity of Ventral Anterior Insula in Asthmatic Patients with Depression |
| title_sort | abnormal functional connectivity of ventral anterior insula in asthmatic patients with depression |
| url | http://dx.doi.org/10.1155/2017/7838035 |
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