Innovative strategy for full-scale polar components explicition and ultrasonic-assisted optimization of Astragalus membranaceus flower
Traditional extraction under merely one specific solvent was confronted with incomplete phytochemical unscramble problem. In view of this, in order to obtain the overall chemical understanding, we attempted to use Astragalus membranaceus flower, an abundant exploitable resource, to screen a novel ex...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-03-01
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| Series: | Ultrasonics Sonochemistry |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1350417725000173 |
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| author | Yumei Wang Meiling Gu Meng Zhang Jialin Mao Yujian Han Qi Liu |
| author_facet | Yumei Wang Meiling Gu Meng Zhang Jialin Mao Yujian Han Qi Liu |
| author_sort | Yumei Wang |
| collection | DOAJ |
| description | Traditional extraction under merely one specific solvent was confronted with incomplete phytochemical unscramble problem. In view of this, in order to obtain the overall chemical understanding, we attempted to use Astragalus membranaceus flower, an abundant exploitable resource, to screen a novel extraction mixing scheme via gradient solvents based on the ions’ quantity detected in UHPLC-Q-TOF-MS/MS approach. Samples were firstly extracted by different concentration ethanol, and then, six mixing schemes were investigated and one scheme with maximum detected ions was screened out. After identification procedures based on an comprehensive reference database, 136 components covered 54 flavonoids were accurately identified, indicating that flavonoids may played a critical role in Astragalus membranaceus flower. Through the Box–Behnken Design optimization, 29.79 mg/g of flavonoids were extracted under ethanol concentration of 35 %, solid–liquid ratio of 1:50, extraction time of 50 min. The experiments showed that the established mixing scheme could obtain more comprehensive ingredients compared to orthodox extraction, further guide the optimization of significative ingredients scientifically. The present paper could promote the development of Astragalus membranaceus flower. |
| format | Article |
| id | doaj-art-f25a02a025314b09a571eeeabd426d4b |
| institution | Kabale University |
| issn | 1350-4177 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ultrasonics Sonochemistry |
| spelling | doaj-art-f25a02a025314b09a571eeeabd426d4b2025-01-30T05:13:48ZengElsevierUltrasonics Sonochemistry1350-41772025-03-01114107238Innovative strategy for full-scale polar components explicition and ultrasonic-assisted optimization of Astragalus membranaceus flowerYumei Wang0Meiling Gu1Meng Zhang2Jialin Mao3Yujian Han4Qi Liu5The Research Institute of Medicine and Pharmacy, Qiqihar Medical University, Qiqihar 161006 ChinaThe Research Institute of Medicine and Pharmacy, Qiqihar Medical University, Qiqihar 161006 China; School of Pharmacy, Qiqihar Medical University, Qiqihar 161006 ChinaThe Research Institute of Medicine and Pharmacy, Qiqihar Medical University, Qiqihar 161006 China; School of Pharmacy, Qiqihar Medical University, Qiqihar 161006 ChinaThe Research Institute of Medicine and Pharmacy, Qiqihar Medical University, Qiqihar 161006 China; School of Pharmacy, Qiqihar Medical University, Qiqihar 161006 ChinaThe Research Institute of Medicine and Pharmacy, Qiqihar Medical University, Qiqihar 161006 China; School of Pharmacy, Qiqihar Medical University, Qiqihar 161006 ChinaThe Research Institute of Medicine and Pharmacy, Qiqihar Medical University, Qiqihar 161006 China; The Institute of Astragalus Industry Research, Qiqihar Medical University, Qiqihar 161006 China; Corresponding author at: The Research Institute of Medicine and Pharmacy, Qiqihar Medical University, Qiqihar 161006, China.Traditional extraction under merely one specific solvent was confronted with incomplete phytochemical unscramble problem. In view of this, in order to obtain the overall chemical understanding, we attempted to use Astragalus membranaceus flower, an abundant exploitable resource, to screen a novel extraction mixing scheme via gradient solvents based on the ions’ quantity detected in UHPLC-Q-TOF-MS/MS approach. Samples were firstly extracted by different concentration ethanol, and then, six mixing schemes were investigated and one scheme with maximum detected ions was screened out. After identification procedures based on an comprehensive reference database, 136 components covered 54 flavonoids were accurately identified, indicating that flavonoids may played a critical role in Astragalus membranaceus flower. Through the Box–Behnken Design optimization, 29.79 mg/g of flavonoids were extracted under ethanol concentration of 35 %, solid–liquid ratio of 1:50, extraction time of 50 min. The experiments showed that the established mixing scheme could obtain more comprehensive ingredients compared to orthodox extraction, further guide the optimization of significative ingredients scientifically. The present paper could promote the development of Astragalus membranaceus flower.http://www.sciencedirect.com/science/article/pii/S1350417725000173Astragalus membranaceus flowerMixing schemesIons’ quantityUltrasonic-assisted extractionFlavonoids |
| spellingShingle | Yumei Wang Meiling Gu Meng Zhang Jialin Mao Yujian Han Qi Liu Innovative strategy for full-scale polar components explicition and ultrasonic-assisted optimization of Astragalus membranaceus flower Ultrasonics Sonochemistry Astragalus membranaceus flower Mixing schemes Ions’ quantity Ultrasonic-assisted extraction Flavonoids |
| title | Innovative strategy for full-scale polar components explicition and ultrasonic-assisted optimization of Astragalus membranaceus flower |
| title_full | Innovative strategy for full-scale polar components explicition and ultrasonic-assisted optimization of Astragalus membranaceus flower |
| title_fullStr | Innovative strategy for full-scale polar components explicition and ultrasonic-assisted optimization of Astragalus membranaceus flower |
| title_full_unstemmed | Innovative strategy for full-scale polar components explicition and ultrasonic-assisted optimization of Astragalus membranaceus flower |
| title_short | Innovative strategy for full-scale polar components explicition and ultrasonic-assisted optimization of Astragalus membranaceus flower |
| title_sort | innovative strategy for full scale polar components explicition and ultrasonic assisted optimization of astragalus membranaceus flower |
| topic | Astragalus membranaceus flower Mixing schemes Ions’ quantity Ultrasonic-assisted extraction Flavonoids |
| url | http://www.sciencedirect.com/science/article/pii/S1350417725000173 |
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