Sugarcane leaves-derived polyphenols alleviate metabolic syndrome and modulate gut microbiota of ob/ob mice
Sugarcane leaves-derived polyphenols (SLP) have been demonstrated to have diverse health-promoting benefits, but the mechanism of action has not been fully elucidated. This study aimed to investigate the anti-metabolic disease effects of SLP and the underlying mechanisms in mice. In the current stud...
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| Format: | Article |
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Tsinghua University Press
2024-03-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | https://www.sciopen.com/article/10.26599/FSHW.2022.9250048 |
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| author | Li Sun Tao Wang Baosong Chen Cui Guo Shanshan Qiao Jinghan Lin Huan Liao Huanqin Dai Bin Wang Jingzu Sun Hongwei Liu |
| author_facet | Li Sun Tao Wang Baosong Chen Cui Guo Shanshan Qiao Jinghan Lin Huan Liao Huanqin Dai Bin Wang Jingzu Sun Hongwei Liu |
| author_sort | Li Sun |
| collection | DOAJ |
| description | Sugarcane leaves-derived polyphenols (SLP) have been demonstrated to have diverse health-promoting benefits, but the mechanism of action has not been fully elucidated. This study aimed to investigate the anti-metabolic disease effects of SLP and the underlying mechanisms in mice. In the current study, we prepared the SLP mainly consisting of three flavonoid glycosides, three phenol derivatives, and two lignans including one new compound, and further demonstrated that SLP reduced body weight gain and fat accumulation, improved glucose and lipid metabolism disorders, ameliorated hepatic steatosis, and regulated short-chain fatty acids (SCFAs) production and secondary bile acids metabolism in ob/ob mice. Notably, SLP largely altered the gut microbiota composition, especially enriching the commensal bacteria Akkermansia muciniphila and Bacteroides acidifaciens. Oral gavage with the above two strains ameliorated metabolic syndrome (MetS), regulated secondary bile acid metabolism, and increased the production of SCFAs in high-fat diet (HFD)-induced obese mice. These results demonstrated that SLP could be used as a prebiotic to attenuate MetS via regulating gut microbiota composition and further activating the secondary bile acids-mediated gut-adipose axis. |
| format | Article |
| id | doaj-art-f24f1475d2ae4029ab6f25a64843f0d9 |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2024-03-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-f24f1475d2ae4029ab6f25a64843f0d92024-12-29T16:00:05ZengTsinghua University PressFood Science and Human Wellness2213-45302024-03-0113263364810.26599/FSHW.2022.9250048Sugarcane leaves-derived polyphenols alleviate metabolic syndrome and modulate gut microbiota of ob/ob miceLi Sun0Tao Wang1Baosong Chen2Cui Guo3Shanshan Qiao4Jinghan Lin5Huan Liao6Huanqin Dai7Bin Wang8Jingzu Sun9Hongwei Liu10State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, ChinaState Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, ChinaState Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, ChinaState Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, ChinaState Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, ChinaState Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, ChinaState Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, ChinaState Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, ChinaGuangxi Academy of Sciences, Nanning 530007, ChinaState Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, ChinaState Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, ChinaSugarcane leaves-derived polyphenols (SLP) have been demonstrated to have diverse health-promoting benefits, but the mechanism of action has not been fully elucidated. This study aimed to investigate the anti-metabolic disease effects of SLP and the underlying mechanisms in mice. In the current study, we prepared the SLP mainly consisting of three flavonoid glycosides, three phenol derivatives, and two lignans including one new compound, and further demonstrated that SLP reduced body weight gain and fat accumulation, improved glucose and lipid metabolism disorders, ameliorated hepatic steatosis, and regulated short-chain fatty acids (SCFAs) production and secondary bile acids metabolism in ob/ob mice. Notably, SLP largely altered the gut microbiota composition, especially enriching the commensal bacteria Akkermansia muciniphila and Bacteroides acidifaciens. Oral gavage with the above two strains ameliorated metabolic syndrome (MetS), regulated secondary bile acid metabolism, and increased the production of SCFAs in high-fat diet (HFD)-induced obese mice. These results demonstrated that SLP could be used as a prebiotic to attenuate MetS via regulating gut microbiota composition and further activating the secondary bile acids-mediated gut-adipose axis.https://www.sciopen.com/article/10.26599/FSHW.2022.9250048sugarcane leaves-derived polyphenolsmetabolic syndromebacteroides acidifaciensakkermansia muciniphilasecondary bile acids metabolism |
| spellingShingle | Li Sun Tao Wang Baosong Chen Cui Guo Shanshan Qiao Jinghan Lin Huan Liao Huanqin Dai Bin Wang Jingzu Sun Hongwei Liu Sugarcane leaves-derived polyphenols alleviate metabolic syndrome and modulate gut microbiota of ob/ob mice Food Science and Human Wellness sugarcane leaves-derived polyphenols metabolic syndrome bacteroides acidifaciens akkermansia muciniphila secondary bile acids metabolism |
| title | Sugarcane leaves-derived polyphenols alleviate metabolic syndrome and modulate gut microbiota of ob/ob mice |
| title_full | Sugarcane leaves-derived polyphenols alleviate metabolic syndrome and modulate gut microbiota of ob/ob mice |
| title_fullStr | Sugarcane leaves-derived polyphenols alleviate metabolic syndrome and modulate gut microbiota of ob/ob mice |
| title_full_unstemmed | Sugarcane leaves-derived polyphenols alleviate metabolic syndrome and modulate gut microbiota of ob/ob mice |
| title_short | Sugarcane leaves-derived polyphenols alleviate metabolic syndrome and modulate gut microbiota of ob/ob mice |
| title_sort | sugarcane leaves derived polyphenols alleviate metabolic syndrome and modulate gut microbiota of ob ob mice |
| topic | sugarcane leaves-derived polyphenols metabolic syndrome bacteroides acidifaciens akkermansia muciniphila secondary bile acids metabolism |
| url | https://www.sciopen.com/article/10.26599/FSHW.2022.9250048 |
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