External stress, formaldehyde, and schizophrenia: a new mouse model for mental illness research

External stress, formaldehyde, and schizophrenia: a new mouse model for mental illness research

Abstract Although MK801-induced NMDA receptor (NMDAR) hypofunction mimics schizophrenia symptoms, the exact factors causing NMDAR inhibition are unknown. Unexpectedly, external stress elicits formaldehyde (FA) generation; FA can induce depression and cognitive impairments by blocking NMDARs. This st...

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Bibliographic Details
Main Authors: Junhao Cheng, Zihui Sun, Hao Zhang, Danrui Zhao, Panpan Wang, Haishu Chen, Wanjia Lyv, Qiangfeng Deng, Yuanyu Fu, Xingzhou Lyv, Tingting Gao, Jinan Xu, Feiyan Zhou, Yiqing Wu, Xu Yang, Ping Ma, Zhiqian Tong
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Schizophrenia
Online Access:https://doi.org/10.1038/s41537-025-00603-3
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