Studies of Olfactory System Neural Plasticity: The Contribution of the Unilateral Naris Occlusion Technique

Unilateral naris occlusion has long been the method of choice for effecting stimulus deprivation in studies of olfactory plasticity. A significant body of literature speaks to the myriad consequences of this manipulation on the ipsilateral olfactory pathway. Early experiments emphasized naris occlus...

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Main Author: David M. Coppola
Format: Article
Language:English
Published: Wiley 2012-01-01
Series:Neural Plasticity
Online Access:http://dx.doi.org/10.1155/2012/351752
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author David M. Coppola
author_facet David M. Coppola
author_sort David M. Coppola
collection DOAJ
description Unilateral naris occlusion has long been the method of choice for effecting stimulus deprivation in studies of olfactory plasticity. A significant body of literature speaks to the myriad consequences of this manipulation on the ipsilateral olfactory pathway. Early experiments emphasized naris occlusion’s deleterious and age-critical effects. More recent studies have focused on life-long vulnerability, particularly on neurogenesis, and compensatory responses to deprivation. Despite the abundance of empirical data, a theoretical framework in which to understand the many sequelae of naris occlusion on olfaction has been elusive. This paper focuses on recent data, new theories, and underappreciated caveats related to the use of this technique in studies of olfactory plasticity.
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spelling doaj-art-f236c31dd1d944f39a1993413f3c987b2025-02-03T01:22:04ZengWileyNeural Plasticity2090-59041687-54432012-01-01201210.1155/2012/351752351752Studies of Olfactory System Neural Plasticity: The Contribution of the Unilateral Naris Occlusion TechniqueDavid M. Coppola0Department of Biology, Randolph Macon College, Ashland, VA 23005, USAUnilateral naris occlusion has long been the method of choice for effecting stimulus deprivation in studies of olfactory plasticity. A significant body of literature speaks to the myriad consequences of this manipulation on the ipsilateral olfactory pathway. Early experiments emphasized naris occlusion’s deleterious and age-critical effects. More recent studies have focused on life-long vulnerability, particularly on neurogenesis, and compensatory responses to deprivation. Despite the abundance of empirical data, a theoretical framework in which to understand the many sequelae of naris occlusion on olfaction has been elusive. This paper focuses on recent data, new theories, and underappreciated caveats related to the use of this technique in studies of olfactory plasticity.http://dx.doi.org/10.1155/2012/351752
spellingShingle David M. Coppola
Studies of Olfactory System Neural Plasticity: The Contribution of the Unilateral Naris Occlusion Technique
Neural Plasticity
title Studies of Olfactory System Neural Plasticity: The Contribution of the Unilateral Naris Occlusion Technique
title_full Studies of Olfactory System Neural Plasticity: The Contribution of the Unilateral Naris Occlusion Technique
title_fullStr Studies of Olfactory System Neural Plasticity: The Contribution of the Unilateral Naris Occlusion Technique
title_full_unstemmed Studies of Olfactory System Neural Plasticity: The Contribution of the Unilateral Naris Occlusion Technique
title_short Studies of Olfactory System Neural Plasticity: The Contribution of the Unilateral Naris Occlusion Technique
title_sort studies of olfactory system neural plasticity the contribution of the unilateral naris occlusion technique
url http://dx.doi.org/10.1155/2012/351752
work_keys_str_mv AT davidmcoppola studiesofolfactorysystemneuralplasticitythecontributionoftheunilateralnarisocclusiontechnique