Liver diseases: epidemiology, causes, trends and predictions
Abstract As a highly complex organ with digestive, endocrine, and immune-regulatory functions, the liver is pivotal in maintaining physiological homeostasis through its roles in metabolism, detoxification, and immune response. Various factors including viruses, alcohol, metabolites, toxins, and othe...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2025-02-01
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| Series: | Signal Transduction and Targeted Therapy |
| Online Access: | https://doi.org/10.1038/s41392-024-02072-z |
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| author | Can Gan Yuan Yuan Haiyuan Shen Jinhang Gao Xiangxin Kong Zhaodi Che Yangkun Guo Hua Wang Erdan Dong Jia Xiao |
| author_facet | Can Gan Yuan Yuan Haiyuan Shen Jinhang Gao Xiangxin Kong Zhaodi Che Yangkun Guo Hua Wang Erdan Dong Jia Xiao |
| author_sort | Can Gan |
| collection | DOAJ |
| description | Abstract As a highly complex organ with digestive, endocrine, and immune-regulatory functions, the liver is pivotal in maintaining physiological homeostasis through its roles in metabolism, detoxification, and immune response. Various factors including viruses, alcohol, metabolites, toxins, and other pathogenic agents can compromise liver function, leading to acute or chronic injury that may progress to end-stage liver diseases. While sharing common features, liver diseases exhibit distinct pathophysiological, clinical, and therapeutic profiles. Currently, liver diseases contribute to approximately 2 million deaths globally each year, imposing significant economic and social burdens worldwide. However, there is no cure for many kinds of liver diseases, partly due to a lack of thorough understanding of the development of these liver diseases. Therefore, this review provides a comprehensive examination of the epidemiology and characteristics of liver diseases, covering a spectrum from acute and chronic conditions to end-stage manifestations. We also highlight the multifaceted mechanisms underlying the initiation and progression of liver diseases, spanning molecular and cellular levels to organ networks. Additionally, this review offers updates on innovative diagnostic techniques, current treatments, and potential therapeutic targets presently under clinical evaluation. Recent advances in understanding the pathogenesis of liver diseases hold critical implications and translational value for the development of novel therapeutic strategies. |
| format | Article |
| id | doaj-art-f2360f84300e42d0a05469ea58a4281e |
| institution | Kabale University |
| issn | 2059-3635 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Signal Transduction and Targeted Therapy |
| spelling | doaj-art-f2360f84300e42d0a05469ea58a4281e2025-02-09T12:56:27ZengNature Publishing GroupSignal Transduction and Targeted Therapy2059-36352025-02-0110113610.1038/s41392-024-02072-zLiver diseases: epidemiology, causes, trends and predictionsCan Gan0Yuan Yuan1Haiyuan Shen2Jinhang Gao3Xiangxin Kong4Zhaodi Che5Yangkun Guo6Hua Wang7Erdan Dong8Jia Xiao9Department of Gastroenterology, West China Hospital, Sichuan UniversityAier Institute of Ophthalmology, Central South UniversityDepartment of Oncology, the First Affiliated Hospital; The Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, Anhui Medical UniversityDepartment of Gastroenterology, West China Hospital, Sichuan UniversityEngineering and Translational Medicine, Medical College, Tianjin UniversityClinical Medicine Research Institute and Department of Anesthesiology, The First Affiliated Hospital of Jinan UniversityDepartment of Gastroenterology, West China Hospital, Sichuan UniversityDepartment of Oncology, the First Affiliated Hospital; The Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, Anhui Medical UniversityResearch Center for Cardiopulmonary Rehabilitation, University of Health and Rehabilitation Sciences Qingdao Hospital, School of Health and Life Sciences, University of Health and Rehabilitation SciencesClinical Medicine Research Institute and Department of Anesthesiology, The First Affiliated Hospital of Jinan UniversityAbstract As a highly complex organ with digestive, endocrine, and immune-regulatory functions, the liver is pivotal in maintaining physiological homeostasis through its roles in metabolism, detoxification, and immune response. Various factors including viruses, alcohol, metabolites, toxins, and other pathogenic agents can compromise liver function, leading to acute or chronic injury that may progress to end-stage liver diseases. While sharing common features, liver diseases exhibit distinct pathophysiological, clinical, and therapeutic profiles. Currently, liver diseases contribute to approximately 2 million deaths globally each year, imposing significant economic and social burdens worldwide. However, there is no cure for many kinds of liver diseases, partly due to a lack of thorough understanding of the development of these liver diseases. Therefore, this review provides a comprehensive examination of the epidemiology and characteristics of liver diseases, covering a spectrum from acute and chronic conditions to end-stage manifestations. We also highlight the multifaceted mechanisms underlying the initiation and progression of liver diseases, spanning molecular and cellular levels to organ networks. Additionally, this review offers updates on innovative diagnostic techniques, current treatments, and potential therapeutic targets presently under clinical evaluation. Recent advances in understanding the pathogenesis of liver diseases hold critical implications and translational value for the development of novel therapeutic strategies.https://doi.org/10.1038/s41392-024-02072-z |
| spellingShingle | Can Gan Yuan Yuan Haiyuan Shen Jinhang Gao Xiangxin Kong Zhaodi Che Yangkun Guo Hua Wang Erdan Dong Jia Xiao Liver diseases: epidemiology, causes, trends and predictions Signal Transduction and Targeted Therapy |
| title | Liver diseases: epidemiology, causes, trends and predictions |
| title_full | Liver diseases: epidemiology, causes, trends and predictions |
| title_fullStr | Liver diseases: epidemiology, causes, trends and predictions |
| title_full_unstemmed | Liver diseases: epidemiology, causes, trends and predictions |
| title_short | Liver diseases: epidemiology, causes, trends and predictions |
| title_sort | liver diseases epidemiology causes trends and predictions |
| url | https://doi.org/10.1038/s41392-024-02072-z |
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