Retrospective study of 100-day mortality in advanced solid malignancies: Real world experience in a tertiary cancer center from South India
Background: Mortality rate serves as the clinical indicator of the quality of care and appropriateness of clinical decisions. However, Indian data on 100-day mortality in patients with Stage IV disease, post-palliative therapy is lacking. Objectives: The primary objective was to assess 100-day morta...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-04-01
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| Series: | Cancer Research, Statistics, and Treatment |
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| Online Access: | https://journals.lww.com/10.4103/crst.crst_239_24 |
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| author | Shashidhar V Karpurmath Shubha Supriya Asaithambi Chevireddy Praneetha Geetika Dandamudi Veerendra Angadi Manjunath Nandennavar |
| author_facet | Shashidhar V Karpurmath Shubha Supriya Asaithambi Chevireddy Praneetha Geetika Dandamudi Veerendra Angadi Manjunath Nandennavar |
| author_sort | Shashidhar V Karpurmath |
| collection | DOAJ |
| description | Background:
Mortality rate serves as the clinical indicator of the quality of care and appropriateness of clinical decisions. However, Indian data on 100-day mortality in patients with Stage IV disease, post-palliative therapy is lacking.
Objectives:
The primary objective was to assess 100-day mortality in patients receiving palliative systemic therapy for advanced solid tumors. The secondary objective was to identify associated predictive factors.
Materials and Methods:
This retrospective cohort study included adults (>18 years) with Stage IV solid malignancies, who were planned for palliative systemic therapy at the Medical Oncology department, from a tertiary cancer center in South India over a 6-month period. Data were retrieved from electronic medical records. Mortality within 100-day was confirmed through records and telephonic interviews. Analysis was performed using Statistical package for the Social Sciences (SPSS) Version 25, (IBM Corp.), with P < 0.050 considered significant.
Results:
We included 144 patients in the study. The median age was 53 years (IQR: 43-62), with 19.4% (n = 28) aged >65 years. Males and females were equally represented. Gastrointestinal and biliary cancers were most common (35.4%, n = 51). Metastatic disease was present in 88.2% (n = 127) of cases, of which 11.8% (n = 15) were oligometastatic. The 100-day mortality rate was 16% (n = 23). Subgroup analysis showed that neutrophil-lymphocyte ratio (P, 0.040) and performance status (P, 0.020) significantly influenced mortality.
Conclusion:
In the era of advanced therapeutics, evaluating 100-day mortality provides insight into clinical decision-making for Stage IV patients. Neutrophil-lymphocyte ratio and performance status are key prognostic indicators. |
| format | Article |
| id | doaj-art-f22d9a0b5afa4f2ea7d1012c64e43819 |
| institution | OA Journals |
| issn | 2590-3233 2590-3225 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Cancer Research, Statistics, and Treatment |
| spelling | doaj-art-f22d9a0b5afa4f2ea7d1012c64e438192025-08-20T02:32:29ZengWolters Kluwer Medknow PublicationsCancer Research, Statistics, and Treatment2590-32332590-32252025-04-018214114810.4103/crst.crst_239_24Retrospective study of 100-day mortality in advanced solid malignancies: Real world experience in a tertiary cancer center from South IndiaShashidhar V KarpurmathShubha Supriya AsaithambiChevireddy PraneethaGeetika DandamudiVeerendra AngadiManjunath NandennavarBackground: Mortality rate serves as the clinical indicator of the quality of care and appropriateness of clinical decisions. However, Indian data on 100-day mortality in patients with Stage IV disease, post-palliative therapy is lacking. Objectives: The primary objective was to assess 100-day mortality in patients receiving palliative systemic therapy for advanced solid tumors. The secondary objective was to identify associated predictive factors. Materials and Methods: This retrospective cohort study included adults (>18 years) with Stage IV solid malignancies, who were planned for palliative systemic therapy at the Medical Oncology department, from a tertiary cancer center in South India over a 6-month period. Data were retrieved from electronic medical records. Mortality within 100-day was confirmed through records and telephonic interviews. Analysis was performed using Statistical package for the Social Sciences (SPSS) Version 25, (IBM Corp.), with P < 0.050 considered significant. Results: We included 144 patients in the study. The median age was 53 years (IQR: 43-62), with 19.4% (n = 28) aged >65 years. Males and females were equally represented. Gastrointestinal and biliary cancers were most common (35.4%, n = 51). Metastatic disease was present in 88.2% (n = 127) of cases, of which 11.8% (n = 15) were oligometastatic. The 100-day mortality rate was 16% (n = 23). Subgroup analysis showed that neutrophil-lymphocyte ratio (P, 0.040) and performance status (P, 0.020) significantly influenced mortality. Conclusion: In the era of advanced therapeutics, evaluating 100-day mortality provides insight into clinical decision-making for Stage IV patients. Neutrophil-lymphocyte ratio and performance status are key prognostic indicators.https://journals.lww.com/10.4103/crst.crst_239_24100-day mortalityindian dataneutrophil-lymphocyte ratiopalliative systemic therapystage iv solid cancers |
| spellingShingle | Shashidhar V Karpurmath Shubha Supriya Asaithambi Chevireddy Praneetha Geetika Dandamudi Veerendra Angadi Manjunath Nandennavar Retrospective study of 100-day mortality in advanced solid malignancies: Real world experience in a tertiary cancer center from South India Cancer Research, Statistics, and Treatment 100-day mortality indian data neutrophil-lymphocyte ratio palliative systemic therapy stage iv solid cancers |
| title | Retrospective study of 100-day mortality in advanced solid malignancies: Real world experience in a tertiary cancer center from South India |
| title_full | Retrospective study of 100-day mortality in advanced solid malignancies: Real world experience in a tertiary cancer center from South India |
| title_fullStr | Retrospective study of 100-day mortality in advanced solid malignancies: Real world experience in a tertiary cancer center from South India |
| title_full_unstemmed | Retrospective study of 100-day mortality in advanced solid malignancies: Real world experience in a tertiary cancer center from South India |
| title_short | Retrospective study of 100-day mortality in advanced solid malignancies: Real world experience in a tertiary cancer center from South India |
| title_sort | retrospective study of 100 day mortality in advanced solid malignancies real world experience in a tertiary cancer center from south india |
| topic | 100-day mortality indian data neutrophil-lymphocyte ratio palliative systemic therapy stage iv solid cancers |
| url | https://journals.lww.com/10.4103/crst.crst_239_24 |
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