Factors Predicting Renal Function Outcome after Augmentation Cystoplasty
We determined the cause of renal deterioration after augmentation cystoplasty (AC). Twenty-nine adult patients with refractory bladder dysfunction and who underwent ileocystoplasty from 2004 to 2015 were studied. Patients with a decline in glomerular filtration rate (GFR) after augmentation were rev...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | International Journal of Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2017/3929352 |
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| author | Shahbaz Mehmood Raouf Seyam Sadia Firdous Waleed Mohammad Altaweel |
| author_facet | Shahbaz Mehmood Raouf Seyam Sadia Firdous Waleed Mohammad Altaweel |
| author_sort | Shahbaz Mehmood |
| collection | DOAJ |
| description | We determined the cause of renal deterioration after augmentation cystoplasty (AC). Twenty-nine adult patients with refractory bladder dysfunction and who underwent ileocystoplasty from 2004 to 2015 were studied. Patients with a decline in glomerular filtration rate (GFR) after augmentation were reviewed. The primary outcome was to determine the factors that might lead to deterioration of estimated GFR. Median follow-up was 7.0±2.6 years. Significant bladder capacity, end filling pressure, and bladder compliance were achieved from median 114±53.6 to 342.1±68.3 ml (p=.0001), 68.5±19.9 to 28.2±6.9 cm H2O (p=.0001), and 3.0±2.1 to 12.8±3.9 (p=.0001), respectively. Renal function remained stable and improved in 22 (76%) patients from median eGFR 135±81.98 to 142.82±94.4 ml/min/1.73 m2 (p=.160). Significant deterioration was found in 7 (24%) patients from median eGFR 68.25±42 to 36.57±35.33 (p=.001). The causes of renal deterioration were noncompliance to self-catheterization (2 patients), posterior urethral valve/dysplastic kidneys (2 patients), and reflux/infection (2 patients). On multivariate analysis, recurrent pyelonephritis (OR 3.87, p=0.0155) and noncompliance (OR 30.78, p=0.0156) were significant. We concluded that AC is not the cause of progression to end-stage renal disease in patients with renal insufficiency. |
| format | Article |
| id | doaj-art-f220729223a0436b9612a02ac351eeaa |
| institution | Kabale University |
| issn | 2090-214X 2090-2158 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
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| series | International Journal of Nephrology |
| spelling | doaj-art-f220729223a0436b9612a02ac351eeaa2025-02-03T01:03:15ZengWileyInternational Journal of Nephrology2090-214X2090-21582017-01-01201710.1155/2017/39293523929352Factors Predicting Renal Function Outcome after Augmentation CystoplastyShahbaz Mehmood0Raouf Seyam1Sadia Firdous2Waleed Mohammad Altaweel3Department of Urology, King Faisal Specialist Hospital & Research Centre, P.O. Box 3354, Riyadh 11211, Saudi ArabiaDepartment of Urology, King Faisal Specialist Hospital & Research Centre, P.O. Box 3354, Riyadh 11211, Saudi ArabiaFatima Jinnah Medical University, Lahore, PakistanDepartment of Urology, King Faisal Specialist Hospital & Research Centre, P.O. Box 3354, Riyadh 11211, Saudi ArabiaWe determined the cause of renal deterioration after augmentation cystoplasty (AC). Twenty-nine adult patients with refractory bladder dysfunction and who underwent ileocystoplasty from 2004 to 2015 were studied. Patients with a decline in glomerular filtration rate (GFR) after augmentation were reviewed. The primary outcome was to determine the factors that might lead to deterioration of estimated GFR. Median follow-up was 7.0±2.6 years. Significant bladder capacity, end filling pressure, and bladder compliance were achieved from median 114±53.6 to 342.1±68.3 ml (p=.0001), 68.5±19.9 to 28.2±6.9 cm H2O (p=.0001), and 3.0±2.1 to 12.8±3.9 (p=.0001), respectively. Renal function remained stable and improved in 22 (76%) patients from median eGFR 135±81.98 to 142.82±94.4 ml/min/1.73 m2 (p=.160). Significant deterioration was found in 7 (24%) patients from median eGFR 68.25±42 to 36.57±35.33 (p=.001). The causes of renal deterioration were noncompliance to self-catheterization (2 patients), posterior urethral valve/dysplastic kidneys (2 patients), and reflux/infection (2 patients). On multivariate analysis, recurrent pyelonephritis (OR 3.87, p=0.0155) and noncompliance (OR 30.78, p=0.0156) were significant. We concluded that AC is not the cause of progression to end-stage renal disease in patients with renal insufficiency.http://dx.doi.org/10.1155/2017/3929352 |
| spellingShingle | Shahbaz Mehmood Raouf Seyam Sadia Firdous Waleed Mohammad Altaweel Factors Predicting Renal Function Outcome after Augmentation Cystoplasty International Journal of Nephrology |
| title | Factors Predicting Renal Function Outcome after Augmentation Cystoplasty |
| title_full | Factors Predicting Renal Function Outcome after Augmentation Cystoplasty |
| title_fullStr | Factors Predicting Renal Function Outcome after Augmentation Cystoplasty |
| title_full_unstemmed | Factors Predicting Renal Function Outcome after Augmentation Cystoplasty |
| title_short | Factors Predicting Renal Function Outcome after Augmentation Cystoplasty |
| title_sort | factors predicting renal function outcome after augmentation cystoplasty |
| url | http://dx.doi.org/10.1155/2017/3929352 |
| work_keys_str_mv | AT shahbazmehmood factorspredictingrenalfunctionoutcomeafteraugmentationcystoplasty AT raoufseyam factorspredictingrenalfunctionoutcomeafteraugmentationcystoplasty AT sadiafirdous factorspredictingrenalfunctionoutcomeafteraugmentationcystoplasty AT waleedmohammadaltaweel factorspredictingrenalfunctionoutcomeafteraugmentationcystoplasty |