Associations of PM2.5 with Chronic Obstructive Pulmonary Disease in Shipyard Workers: A Cohort Study
Abstract The association between lung deposition of particulate matter with an aerodynamic diameter less than 2.5 µm (PM2.5) from welding fumes and lung function is unclear. We conducted a cohort study with a follow-up of 4 years in 115 shipyard workers to investigate the incidence rate of chronic o...
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| Format: | Article |
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Springer
2022-04-01
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| Series: | Aerosol and Air Quality Research |
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| Online Access: | https://doi.org/10.4209/aaqr.210272 |
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| author | Nguyen Thanh Tung Ching-Huang Lai Chih-Hong Pan Wei-Liang Chen Chung-Ching Wang Che-Wei Liang Chi-Yu Chien Kai-Jen Chuang Huynh Nguyen Xuan Thao Hoang Ba Dung Tran Phan Chung Thuy Hsiao-Chi Chuang |
| author_facet | Nguyen Thanh Tung Ching-Huang Lai Chih-Hong Pan Wei-Liang Chen Chung-Ching Wang Che-Wei Liang Chi-Yu Chien Kai-Jen Chuang Huynh Nguyen Xuan Thao Hoang Ba Dung Tran Phan Chung Thuy Hsiao-Chi Chuang |
| author_sort | Nguyen Thanh Tung |
| collection | DOAJ |
| description | Abstract The association between lung deposition of particulate matter with an aerodynamic diameter less than 2.5 µm (PM2.5) from welding fumes and lung function is unclear. We conducted a cohort study with a follow-up of 4 years in 115 shipyard workers to investigate the incidence rate of chronic obstructive pulmonary disease (COPD), and to evaluate the effects of welding fume PM2.5 deposition on fractional exhaled nitric oxide (FeNO), lung function, and blood pressure using generalized estimating equation models. Personal exposure to welding fumes was measured, and deposition fractions of inhaled welding fume PM2.5 in lung regions were estimated using multiple-path particle dosimetry. We observed the overall incidence rate of COPD to be 2.51 cases per 100 person-years. The incidence rate was higher in welding workers than in office workers and higher in non-smokers compared to smokers. In the overall cohort subjects, we observed that an increase in the interquartile range of PM2.5 was associated with a 1.618-ppb decrease in FeNO, a 0.115-L decrease in FVC, a 0.091-L decrease in FEV1, a 0.520% increase in the FEV1/FVC ratio, a 0.259-L s−1 decrease in PEF, a 0.096-L s−1 decrease in FEF25%–75%, a 0.215-L s−1 decrease in FEF25%, and a 0.114-L s−1 decrease in FEF50% (all p < 0.05). We observed that a 1-µg m−3 increase in PM2.5 deposition in lung regions (total lung, and head and nasal, tracheobronchial, and alveolar regions) was associated with decreases (β coefficients) in FeNO, FVC, FEV1, PEF, FEF25%–75%, FEF25%, and FEF50% (all p < 0.05). We observed that the absolute values of β coefficients decreased as follows: alveolar > head and nasal > tracheobronchial > total lung regions. Higher incidence rates of COPD were observed in non-smokers and welders, which associated with lung function declines due to PM2.5 exposure. Pulmonary effects by welding fume PM2.5 in occupational settings is an urgent occupational issue for worker health protection. |
| format | Article |
| id | doaj-art-f204b9d74e6e4d64b624dd151ba09b25 |
| institution | Kabale University |
| issn | 1680-8584 2071-1409 |
| language | English |
| publishDate | 2022-04-01 |
| publisher | Springer |
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| series | Aerosol and Air Quality Research |
| spelling | doaj-art-f204b9d74e6e4d64b624dd151ba09b252025-02-09T12:17:55ZengSpringerAerosol and Air Quality Research1680-85842071-14092022-04-0122511410.4209/aaqr.210272Associations of PM2.5 with Chronic Obstructive Pulmonary Disease in Shipyard Workers: A Cohort StudyNguyen Thanh Tung0Ching-Huang Lai1Chih-Hong Pan2Wei-Liang Chen3Chung-Ching Wang4Che-Wei Liang5Chi-Yu Chien6Kai-Jen Chuang7Huynh Nguyen Xuan Thao8Hoang Ba Dung9Tran Phan Chung Thuy10Hsiao-Chi Chuang11International Ph.D. Program in Medicine, College of Medicine, Taipei Medical UniversitySchool of Public Health, National Defense Medical CenterSchool of Public Health, National Defense Medical CenterDivision of Family Medicine, Department of Family and Community Medicine, Tri-Service General HospitalDivision of Family Medicine, Department of Family and Community Medicine, Tri-Service General HospitalSchool of Public Health, National Defense Medical CenterSchool of Public Health, National Defense Medical CenterSchool of Public Health, College of Public Health, Taipei Medical UniversityOtorhinolaryngology Department, Ho Chi Minh City University of Medicine and PharmacyOtorhinolaryngology Department, Cho Ray HospitalOtorhinolaryngology Department, Faculty of Medicine, Vietnam National University Ho Chi Minh CitySchool of Respiratory Therapy, College of Medicine, Taipei Medical UniversityAbstract The association between lung deposition of particulate matter with an aerodynamic diameter less than 2.5 µm (PM2.5) from welding fumes and lung function is unclear. We conducted a cohort study with a follow-up of 4 years in 115 shipyard workers to investigate the incidence rate of chronic obstructive pulmonary disease (COPD), and to evaluate the effects of welding fume PM2.5 deposition on fractional exhaled nitric oxide (FeNO), lung function, and blood pressure using generalized estimating equation models. Personal exposure to welding fumes was measured, and deposition fractions of inhaled welding fume PM2.5 in lung regions were estimated using multiple-path particle dosimetry. We observed the overall incidence rate of COPD to be 2.51 cases per 100 person-years. The incidence rate was higher in welding workers than in office workers and higher in non-smokers compared to smokers. In the overall cohort subjects, we observed that an increase in the interquartile range of PM2.5 was associated with a 1.618-ppb decrease in FeNO, a 0.115-L decrease in FVC, a 0.091-L decrease in FEV1, a 0.520% increase in the FEV1/FVC ratio, a 0.259-L s−1 decrease in PEF, a 0.096-L s−1 decrease in FEF25%–75%, a 0.215-L s−1 decrease in FEF25%, and a 0.114-L s−1 decrease in FEF50% (all p < 0.05). We observed that a 1-µg m−3 increase in PM2.5 deposition in lung regions (total lung, and head and nasal, tracheobronchial, and alveolar regions) was associated with decreases (β coefficients) in FeNO, FVC, FEV1, PEF, FEF25%–75%, FEF25%, and FEF50% (all p < 0.05). We observed that the absolute values of β coefficients decreased as follows: alveolar > head and nasal > tracheobronchial > total lung regions. Higher incidence rates of COPD were observed in non-smokers and welders, which associated with lung function declines due to PM2.5 exposure. Pulmonary effects by welding fume PM2.5 in occupational settings is an urgent occupational issue for worker health protection.https://doi.org/10.4209/aaqr.210272Air pollutionAlveoliCOPDParticulate matterWelding fume |
| spellingShingle | Nguyen Thanh Tung Ching-Huang Lai Chih-Hong Pan Wei-Liang Chen Chung-Ching Wang Che-Wei Liang Chi-Yu Chien Kai-Jen Chuang Huynh Nguyen Xuan Thao Hoang Ba Dung Tran Phan Chung Thuy Hsiao-Chi Chuang Associations of PM2.5 with Chronic Obstructive Pulmonary Disease in Shipyard Workers: A Cohort Study Aerosol and Air Quality Research Air pollution Alveoli COPD Particulate matter Welding fume |
| title | Associations of PM2.5 with Chronic Obstructive Pulmonary Disease in Shipyard Workers: A Cohort Study |
| title_full | Associations of PM2.5 with Chronic Obstructive Pulmonary Disease in Shipyard Workers: A Cohort Study |
| title_fullStr | Associations of PM2.5 with Chronic Obstructive Pulmonary Disease in Shipyard Workers: A Cohort Study |
| title_full_unstemmed | Associations of PM2.5 with Chronic Obstructive Pulmonary Disease in Shipyard Workers: A Cohort Study |
| title_short | Associations of PM2.5 with Chronic Obstructive Pulmonary Disease in Shipyard Workers: A Cohort Study |
| title_sort | associations of pm2 5 with chronic obstructive pulmonary disease in shipyard workers a cohort study |
| topic | Air pollution Alveoli COPD Particulate matter Welding fume |
| url | https://doi.org/10.4209/aaqr.210272 |
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