Transforming pancreaticobiliary cancer treatment: Exploring the frontiers of adoptive cell therapy and cancer vaccines
Pancreaticobiliary cancer, encompassing malignancies of both the pancreatic and biliary tract, presents a formidable clinical challenge marked by a uniformly bleak prognosis. The asymptomatic nature of its early stages often leads to delayed detection, contributing to an unfavorable 5-year overall s...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-09-01
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| Series: | Molecular Therapy: Oncology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2950329924000675 |
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| author | Nawal Amhis Julie Carignan Lee-Hwa Tai |
| author_facet | Nawal Amhis Julie Carignan Lee-Hwa Tai |
| author_sort | Nawal Amhis |
| collection | DOAJ |
| description | Pancreaticobiliary cancer, encompassing malignancies of both the pancreatic and biliary tract, presents a formidable clinical challenge marked by a uniformly bleak prognosis. The asymptomatic nature of its early stages often leads to delayed detection, contributing to an unfavorable 5-year overall survival rate. Conventional treatment modalities have shown limited efficacy, underscoring the urgent need for alternative therapeutic approaches. In recent years, immunotherapy has emerged as a promising avenue in the fight against pancreaticobiliary cancer. Strategies such as therapeutic vaccines and the use of tumor-infiltrating lymphocytes have garnered attention for their potential to elicit more robust and durable responses. This review seeks to illuminate the landscape of emerging immunotherapeutic interventions, offering insights from both clinical and research perspectives. By deepening our understanding of pancreaticobiliary cancer and exploring innovative treatment modalities, we aim to catalyze improvements in patient outcomes and quality of life. |
| format | Article |
| id | doaj-art-f1e8d74ee24545918f4e91eae17b6659 |
| institution | OA Journals |
| issn | 2950-3299 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Molecular Therapy: Oncology |
| spelling | doaj-art-f1e8d74ee24545918f4e91eae17b66592025-08-20T02:32:49ZengElsevierMolecular Therapy: Oncology2950-32992024-09-0132320082510.1016/j.omton.2024.200825Transforming pancreaticobiliary cancer treatment: Exploring the frontiers of adoptive cell therapy and cancer vaccinesNawal Amhis0Julie Carignan1Lee-Hwa Tai2Department of Immunology and Cell Biology, Université de Sherbrooke, Sherbrooke, QC J1E 4K8, Canada; Department of Surgery, Division of General Surgery, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, CanadaCentre de Recherche du CHUS, Sherbrooke, QC J1H 5N4, CanadaDepartment of Immunology and Cell Biology, Université de Sherbrooke, Sherbrooke, QC J1E 4K8, Canada; Centre de Recherche du CHUS, Sherbrooke, QC J1H 5N4, Canada; Corresponding author: Lee-Hwa Tai, Department of Immunology and Cell Biology, Université de Sherbrooke, Sherbrooke, QC J1E 4K8, Canada.Pancreaticobiliary cancer, encompassing malignancies of both the pancreatic and biliary tract, presents a formidable clinical challenge marked by a uniformly bleak prognosis. The asymptomatic nature of its early stages often leads to delayed detection, contributing to an unfavorable 5-year overall survival rate. Conventional treatment modalities have shown limited efficacy, underscoring the urgent need for alternative therapeutic approaches. In recent years, immunotherapy has emerged as a promising avenue in the fight against pancreaticobiliary cancer. Strategies such as therapeutic vaccines and the use of tumor-infiltrating lymphocytes have garnered attention for their potential to elicit more robust and durable responses. This review seeks to illuminate the landscape of emerging immunotherapeutic interventions, offering insights from both clinical and research perspectives. By deepening our understanding of pancreaticobiliary cancer and exploring innovative treatment modalities, we aim to catalyze improvements in patient outcomes and quality of life.http://www.sciencedirect.com/science/article/pii/S2950329924000675MT: Regular IssueImmunologygastrointestinal cancerpancreas ductal adenocarcinomacholangiocarcinomacancer vaccine |
| spellingShingle | Nawal Amhis Julie Carignan Lee-Hwa Tai Transforming pancreaticobiliary cancer treatment: Exploring the frontiers of adoptive cell therapy and cancer vaccines Molecular Therapy: Oncology MT: Regular Issue Immunology gastrointestinal cancer pancreas ductal adenocarcinoma cholangiocarcinoma cancer vaccine |
| title | Transforming pancreaticobiliary cancer treatment: Exploring the frontiers of adoptive cell therapy and cancer vaccines |
| title_full | Transforming pancreaticobiliary cancer treatment: Exploring the frontiers of adoptive cell therapy and cancer vaccines |
| title_fullStr | Transforming pancreaticobiliary cancer treatment: Exploring the frontiers of adoptive cell therapy and cancer vaccines |
| title_full_unstemmed | Transforming pancreaticobiliary cancer treatment: Exploring the frontiers of adoptive cell therapy and cancer vaccines |
| title_short | Transforming pancreaticobiliary cancer treatment: Exploring the frontiers of adoptive cell therapy and cancer vaccines |
| title_sort | transforming pancreaticobiliary cancer treatment exploring the frontiers of adoptive cell therapy and cancer vaccines |
| topic | MT: Regular Issue Immunology gastrointestinal cancer pancreas ductal adenocarcinoma cholangiocarcinoma cancer vaccine |
| url | http://www.sciencedirect.com/science/article/pii/S2950329924000675 |
| work_keys_str_mv | AT nawalamhis transformingpancreaticobiliarycancertreatmentexploringthefrontiersofadoptivecelltherapyandcancervaccines AT juliecarignan transformingpancreaticobiliarycancertreatmentexploringthefrontiersofadoptivecelltherapyandcancervaccines AT leehwatai transformingpancreaticobiliarycancertreatmentexploringthefrontiersofadoptivecelltherapyandcancervaccines |