Structural basis of SIRT7 nucleosome engagement and substrate specificity
Abstract Chromatin-modifying enzymes target distinct residues within histones to finetune gene expression profiles. SIRT7 is an NAD+-dependent deacylase often deregulated in cancer, which deacetylates either H3 lysine 36 (H3K36) or H3K18 with high specificity within nucleosomes. Here, we report stru...
Saved in:
Main Authors: | Carlos Moreno-Yruela, Babatunde E. Ekundayo, Polina N. Foteva, Dongchun Ni, Esther Calvino-Sanles, Henning Stahlberg, Beat Fierz |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2025-02-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-025-56529-y |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
MagIC beads for scarce macromolecules
by: Carlos Moreno-Yruela, et al.
Published: (2025-01-01) -
Nucleosome repositioning in cardiac reprogramming
by: Sonalí Harris, et al.
Published: (2025-01-01) -
NUCLEOSOME ORGANIZATION IN PLANT DNA SATELLITES
by: V. N. Babenko, et al.
Published: (2014-12-01) -
Identification of a binding site for small molecule inhibitors targeting human TRPM4
by: Babatunde Ekundayo, et al.
Published: (2025-01-01) -
Nucleosome patterns in four plant pathogenic fungi with contrasted genome structures
by: Clairet, Colin, et al.
Published: (2023-01-01)