Homeostatic T Cell Proliferation after Islet Transplantation
Pancreatic islet transplantation in patients with type 1 diabetes mellitus is performed under immunosuppression to avoid alloreactive T cell responses and to control the reactivation of autoreactive memory T cells. However, lymphopenia associated with immunosuppression and T cell depletion can induc...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2013/217934 |
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| author | Paolo Monti Lorenzo Piemonti |
| author_facet | Paolo Monti Lorenzo Piemonti |
| author_sort | Paolo Monti |
| collection | DOAJ |
| description | Pancreatic islet transplantation in patients with type 1 diabetes mellitus is performed under immunosuppression to avoid alloreactive T cell responses and to control the reactivation of autoreactive memory T cells. However, lymphopenia associated with immunosuppression and T cell depletion can induce a paradoxical expansion of lymphocyte subsets under the influence of homeostatic proliferation. Homeostatic T cell proliferation is mainly driven by the IL-7/IL-7 receptor axis, a molecular pathway which is not affected by standard immune-suppressive drugs and, consequently, represents a novel potential target for immuno-modulatory strategies. In this review, we will discuss how homeostatic T cell proliferation can support autoimmunity recurrence after islet transplantation and how it can be targeted by new therapeutic approaches. |
| format | Article |
| id | doaj-art-f1c6454b1e2e4068a7b01fa70c1da79f |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-f1c6454b1e2e4068a7b01fa70c1da79f2025-02-03T01:23:32ZengWileyClinical and Developmental Immunology1740-25221740-25302013-01-01201310.1155/2013/217934217934Homeostatic T Cell Proliferation after Islet TransplantationPaolo Monti0Lorenzo Piemonti1San Raffaele Diabetes Research Institute, San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milan, ItalySan Raffaele Diabetes Research Institute, San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milan, ItalyPancreatic islet transplantation in patients with type 1 diabetes mellitus is performed under immunosuppression to avoid alloreactive T cell responses and to control the reactivation of autoreactive memory T cells. However, lymphopenia associated with immunosuppression and T cell depletion can induce a paradoxical expansion of lymphocyte subsets under the influence of homeostatic proliferation. Homeostatic T cell proliferation is mainly driven by the IL-7/IL-7 receptor axis, a molecular pathway which is not affected by standard immune-suppressive drugs and, consequently, represents a novel potential target for immuno-modulatory strategies. In this review, we will discuss how homeostatic T cell proliferation can support autoimmunity recurrence after islet transplantation and how it can be targeted by new therapeutic approaches.http://dx.doi.org/10.1155/2013/217934 |
| spellingShingle | Paolo Monti Lorenzo Piemonti Homeostatic T Cell Proliferation after Islet Transplantation Clinical and Developmental Immunology |
| title | Homeostatic T Cell Proliferation after Islet Transplantation |
| title_full | Homeostatic T Cell Proliferation after Islet Transplantation |
| title_fullStr | Homeostatic T Cell Proliferation after Islet Transplantation |
| title_full_unstemmed | Homeostatic T Cell Proliferation after Islet Transplantation |
| title_short | Homeostatic T Cell Proliferation after Islet Transplantation |
| title_sort | homeostatic t cell proliferation after islet transplantation |
| url | http://dx.doi.org/10.1155/2013/217934 |
| work_keys_str_mv | AT paolomonti homeostatictcellproliferationafterislettransplantation AT lorenzopiemonti homeostatictcellproliferationafterislettransplantation |