Anger Emotional Stress Influences VEGF/VEGFR2 and Its Induced PI3K/AKT/mTOR Signaling Pathway
Objective. We discuss the influence of anger emotional stress upon VEGF/VEGFR2 and its induced PI3K/AKT/mTOR signal pathway. Methods. We created a rat model of induced anger (anger-out and anger-in) emotional response using social isolation and resident-intruder paradigms and assessed changes in hip...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2016/4129015 |
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| _version_ | 1832553370401898496 |
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| author | Peng Sun Sheng Wei Xia Wei Jieqiong Wang Yuanyuan Zhang Mingqi Qiao Jibiao Wu |
| author_facet | Peng Sun Sheng Wei Xia Wei Jieqiong Wang Yuanyuan Zhang Mingqi Qiao Jibiao Wu |
| author_sort | Peng Sun |
| collection | DOAJ |
| description | Objective. We discuss the influence of anger emotional stress upon VEGF/VEGFR2 and its induced PI3K/AKT/mTOR signal pathway. Methods. We created a rat model of induced anger (anger-out and anger-in) emotional response using social isolation and resident-intruder paradigms and assessed changes in hippocampus’ VEGF content, neuroplasticity, and the PI3K/AKT/mTOR signaling pathway. Results. The resident-intruder method successfully generated anger-out and anger-in models that differed significantly in composite aggression score, aggression incubation, open field behavior, sucrose preference, and weight gain. Anger emotional stress decreased synaptic connections and VEGFR2 expression. Anger emotional stress led to abnormal expression of VEGF/VEGFR2 mRNA and protein and disorderly expression of key factors in the PI3K/AKT/mTOR signal pathway. Fluoxetine administration ameliorated behavioral abnormalities and damage to hippocampal neurons caused by anger emotional stress, as well as abnormal expression of some proteins in VEGF/VEGFR2 and its induced PI3K/AKT/mTOR signal pathway. Conclusion. This research provides a detailed classification of anger emotion and verifies its influence upon VEGF and the VEGF-induced signaling pathway, thus providing circumstantial evidence of mechanisms by which anger emotion damages neurogenesis. As VEGFR2 can promote neurogenesis and vasculogenesis in the hippocampus and frontal lobe, these results suggest that anger emotional stress can result in decreased neurogenesis. |
| format | Article |
| id | doaj-art-f1c2e0d55ac2420fa3930c08faca6265 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-f1c2e0d55ac2420fa3930c08faca62652025-02-03T05:54:15ZengWileyNeural Plasticity2090-59041687-54432016-01-01201610.1155/2016/41290154129015Anger Emotional Stress Influences VEGF/VEGFR2 and Its Induced PI3K/AKT/mTOR Signaling PathwayPeng Sun0Sheng Wei1Xia Wei2Jieqiong Wang3Yuanyuan Zhang4Mingqi Qiao5Jibiao Wu6College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250355, ChinaExperiment Center, Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250355, ChinaTechnical Office of Pharmacology, Shandong Institute for Food and Drug Control, Jinan 250351, ChinaCollege of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250355, ChinaCollege of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250355, ChinaSchool of Preclinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250355, ChinaSchool of Preclinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250355, ChinaObjective. We discuss the influence of anger emotional stress upon VEGF/VEGFR2 and its induced PI3K/AKT/mTOR signal pathway. Methods. We created a rat model of induced anger (anger-out and anger-in) emotional response using social isolation and resident-intruder paradigms and assessed changes in hippocampus’ VEGF content, neuroplasticity, and the PI3K/AKT/mTOR signaling pathway. Results. The resident-intruder method successfully generated anger-out and anger-in models that differed significantly in composite aggression score, aggression incubation, open field behavior, sucrose preference, and weight gain. Anger emotional stress decreased synaptic connections and VEGFR2 expression. Anger emotional stress led to abnormal expression of VEGF/VEGFR2 mRNA and protein and disorderly expression of key factors in the PI3K/AKT/mTOR signal pathway. Fluoxetine administration ameliorated behavioral abnormalities and damage to hippocampal neurons caused by anger emotional stress, as well as abnormal expression of some proteins in VEGF/VEGFR2 and its induced PI3K/AKT/mTOR signal pathway. Conclusion. This research provides a detailed classification of anger emotion and verifies its influence upon VEGF and the VEGF-induced signaling pathway, thus providing circumstantial evidence of mechanisms by which anger emotion damages neurogenesis. As VEGFR2 can promote neurogenesis and vasculogenesis in the hippocampus and frontal lobe, these results suggest that anger emotional stress can result in decreased neurogenesis.http://dx.doi.org/10.1155/2016/4129015 |
| spellingShingle | Peng Sun Sheng Wei Xia Wei Jieqiong Wang Yuanyuan Zhang Mingqi Qiao Jibiao Wu Anger Emotional Stress Influences VEGF/VEGFR2 and Its Induced PI3K/AKT/mTOR Signaling Pathway Neural Plasticity |
| title | Anger Emotional Stress Influences VEGF/VEGFR2 and Its Induced PI3K/AKT/mTOR Signaling Pathway |
| title_full | Anger Emotional Stress Influences VEGF/VEGFR2 and Its Induced PI3K/AKT/mTOR Signaling Pathway |
| title_fullStr | Anger Emotional Stress Influences VEGF/VEGFR2 and Its Induced PI3K/AKT/mTOR Signaling Pathway |
| title_full_unstemmed | Anger Emotional Stress Influences VEGF/VEGFR2 and Its Induced PI3K/AKT/mTOR Signaling Pathway |
| title_short | Anger Emotional Stress Influences VEGF/VEGFR2 and Its Induced PI3K/AKT/mTOR Signaling Pathway |
| title_sort | anger emotional stress influences vegf vegfr2 and its induced pi3k akt mtor signaling pathway |
| url | http://dx.doi.org/10.1155/2016/4129015 |
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