From superior contrast to super resolution label free optical microscopy
Abstract Label-free optical microscopy utilizes the information encoded in light scattered off unlabeled particles to generate the images. This review article starts off with a discussion on how this light matter interaction gives rise to the issues of poor-contrast and diffraction-limited spatial r...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-01-01
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| Series: | npj Imaging |
| Online Access: | https://doi.org/10.1038/s44303-024-00064-w |
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| _version_ | 1832594521167233024 |
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| author | Nikhil Jayakumar Balpreet Singh Ahluwalia |
| author_facet | Nikhil Jayakumar Balpreet Singh Ahluwalia |
| author_sort | Nikhil Jayakumar |
| collection | DOAJ |
| description | Abstract Label-free optical microscopy utilizes the information encoded in light scattered off unlabeled particles to generate the images. This review article starts off with a discussion on how this light matter interaction gives rise to the issues of poor-contrast and diffraction-limited spatial resolution. Then, this article reviews the various far-field label-free optical microscopy techniques that have been developed, with an emphasis on the physical mechanisms behind the image formation processes in such techniques. Thus the article aims to elucidate the various state-of-the-art label-free techniques and their current applications. |
| format | Article |
| id | doaj-art-f1a5b92c8e2c49b8b3b9b6a90fb3da0a |
| institution | Kabale University |
| issn | 2948-197X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Imaging |
| spelling | doaj-art-f1a5b92c8e2c49b8b3b9b6a90fb3da0a2025-01-19T12:35:11ZengNature Portfolionpj Imaging2948-197X2025-01-013111610.1038/s44303-024-00064-wFrom superior contrast to super resolution label free optical microscopyNikhil Jayakumar0Balpreet Singh Ahluwalia1Department of Physics and Technology, UiT, The Arctic University of NorwayDepartment of Physics and Technology, UiT, The Arctic University of NorwayAbstract Label-free optical microscopy utilizes the information encoded in light scattered off unlabeled particles to generate the images. This review article starts off with a discussion on how this light matter interaction gives rise to the issues of poor-contrast and diffraction-limited spatial resolution. Then, this article reviews the various far-field label-free optical microscopy techniques that have been developed, with an emphasis on the physical mechanisms behind the image formation processes in such techniques. Thus the article aims to elucidate the various state-of-the-art label-free techniques and their current applications.https://doi.org/10.1038/s44303-024-00064-w |
| spellingShingle | Nikhil Jayakumar Balpreet Singh Ahluwalia From superior contrast to super resolution label free optical microscopy npj Imaging |
| title | From superior contrast to super resolution label free optical microscopy |
| title_full | From superior contrast to super resolution label free optical microscopy |
| title_fullStr | From superior contrast to super resolution label free optical microscopy |
| title_full_unstemmed | From superior contrast to super resolution label free optical microscopy |
| title_short | From superior contrast to super resolution label free optical microscopy |
| title_sort | from superior contrast to super resolution label free optical microscopy |
| url | https://doi.org/10.1038/s44303-024-00064-w |
| work_keys_str_mv | AT nikhiljayakumar fromsuperiorcontrasttosuperresolutionlabelfreeopticalmicroscopy AT balpreetsinghahluwalia fromsuperiorcontrasttosuperresolutionlabelfreeopticalmicroscopy |