HIGH DOSES OF STATINS BEFORE PERCUTANEOUS CORONARY INTERVENTION: WHETHER THERE ARE REASONS TO USE?
The results of prospective randomized clinical trials planned to assess the efficacy of using statins in high doses before percutaneous coronary interventions (PCI) are presented in the review. The effect of this approach on the severity of myocardial damage and clinical outcomes in planned PCI in p...
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| Format: | Article |
| Language: | English |
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Столичная издательская компания
2017-09-01
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| Series: | Рациональная фармакотерапия в кардиологии |
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| Online Access: | https://www.rpcardio.online/jour/article/view/1515 |
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| author | I. S. Yavelov M. V. Zhatkina O. M. Drapkina A. Yu. Gorshkov N. O. Myasnikova |
| author_facet | I. S. Yavelov M. V. Zhatkina O. M. Drapkina A. Yu. Gorshkov N. O. Myasnikova |
| author_sort | I. S. Yavelov |
| collection | DOAJ |
| description | The results of prospective randomized clinical trials planned to assess the efficacy of using statins in high doses before percutaneous coronary interventions (PCI) are presented in the review. The effect of this approach on the severity of myocardial damage and clinical outcomes in planned PCI in patients with stable ischemic heart disease (IHD) and early PCI in acute coronary syndrome (ACS) without stable ST-segment elevation was found. The results of the trials planned to study the incidence of contrast-induced nephropathy as well as data from meta-analyzes of conducted clinical trials are demonstrated.According to the accumulated facts, taking high doses of statins before PCI can contribute to reduce myocardial damage with a decrease in the risk of periprocedural myocardial infarction. This effect was demonstrated in the planned coronary stenting in patients with stable IHD and in PCI in the first days of treatment of ACS without the stable ST-segment elevation. It was found both in patients who had not previously taken statins and in patients permanently treated with statins. The additional expected benefit of using a high dose of statins prior to PCI is the prevention of contrast-induced nephropathy. However, due to the limited evidence base, there is no consensus on the advisability of such an approach in current clinical guidelines. |
| format | Article |
| id | doaj-art-f1a519f7293840c39c1fdc6c89cd2b43 |
| institution | Kabale University |
| issn | 1819-6446 2225-3653 |
| language | English |
| publishDate | 2017-09-01 |
| publisher | Столичная издательская компания |
| record_format | Article |
| series | Рациональная фармакотерапия в кардиологии |
| spelling | doaj-art-f1a519f7293840c39c1fdc6c89cd2b432025-08-23T10:00:28ZengСтоличная издательская компанияРациональная фармакотерапия в кардиологии1819-64462225-36532017-09-0113453254010.20996/1819-6446-2017-13-4-532-5401373HIGH DOSES OF STATINS BEFORE PERCUTANEOUS CORONARY INTERVENTION: WHETHER THERE ARE REASONS TO USE?I. S. Yavelov0M. V. Zhatkina1O. M. Drapkina2A. Yu. Gorshkov3N. O. Myasnikova4National Medical Research Centre for Preventive MedicineNational Medical Research Centre for Preventive MedicineNational Medical Research Centre for Preventive MedicineNational Medical Research Centre for Preventive MedicinePirogov Russian National Research Medical UniversityThe results of prospective randomized clinical trials planned to assess the efficacy of using statins in high doses before percutaneous coronary interventions (PCI) are presented in the review. The effect of this approach on the severity of myocardial damage and clinical outcomes in planned PCI in patients with stable ischemic heart disease (IHD) and early PCI in acute coronary syndrome (ACS) without stable ST-segment elevation was found. The results of the trials planned to study the incidence of contrast-induced nephropathy as well as data from meta-analyzes of conducted clinical trials are demonstrated.According to the accumulated facts, taking high doses of statins before PCI can contribute to reduce myocardial damage with a decrease in the risk of periprocedural myocardial infarction. This effect was demonstrated in the planned coronary stenting in patients with stable IHD and in PCI in the first days of treatment of ACS without the stable ST-segment elevation. It was found both in patients who had not previously taken statins and in patients permanently treated with statins. The additional expected benefit of using a high dose of statins prior to PCI is the prevention of contrast-induced nephropathy. However, due to the limited evidence base, there is no consensus on the advisability of such an approach in current clinical guidelines.https://www.rpcardio.online/jour/article/view/1515percutaneous coronary interventioncoronary stentingstatinsmyocardial infarctionacute coronary syndromecontrast-induced nephropathy |
| spellingShingle | I. S. Yavelov M. V. Zhatkina O. M. Drapkina A. Yu. Gorshkov N. O. Myasnikova HIGH DOSES OF STATINS BEFORE PERCUTANEOUS CORONARY INTERVENTION: WHETHER THERE ARE REASONS TO USE? Рациональная фармакотерапия в кардиологии percutaneous coronary intervention coronary stenting statins myocardial infarction acute coronary syndrome contrast-induced nephropathy |
| title | HIGH DOSES OF STATINS BEFORE PERCUTANEOUS CORONARY INTERVENTION: WHETHER THERE ARE REASONS TO USE? |
| title_full | HIGH DOSES OF STATINS BEFORE PERCUTANEOUS CORONARY INTERVENTION: WHETHER THERE ARE REASONS TO USE? |
| title_fullStr | HIGH DOSES OF STATINS BEFORE PERCUTANEOUS CORONARY INTERVENTION: WHETHER THERE ARE REASONS TO USE? |
| title_full_unstemmed | HIGH DOSES OF STATINS BEFORE PERCUTANEOUS CORONARY INTERVENTION: WHETHER THERE ARE REASONS TO USE? |
| title_short | HIGH DOSES OF STATINS BEFORE PERCUTANEOUS CORONARY INTERVENTION: WHETHER THERE ARE REASONS TO USE? |
| title_sort | high doses of statins before percutaneous coronary intervention whether there are reasons to use |
| topic | percutaneous coronary intervention coronary stenting statins myocardial infarction acute coronary syndrome contrast-induced nephropathy |
| url | https://www.rpcardio.online/jour/article/view/1515 |
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