AAV-based vectors for human diseases modeling in laboratory animals
The development of therapeutic drugs and vaccines requires the availability of appropriate model animals that replicate the pathogenesis of human diseases. Both native and transgenic animals can be utilized as models. The advantage of transgenic animals lies in their ability to simulate specific pro...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2024.1499605/full |
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| author | Timur I. Aliev Dmitry V. Yudkin |
| author_facet | Timur I. Aliev Dmitry V. Yudkin |
| author_sort | Timur I. Aliev |
| collection | DOAJ |
| description | The development of therapeutic drugs and vaccines requires the availability of appropriate model animals that replicate the pathogenesis of human diseases. Both native and transgenic animals can be utilized as models. The advantage of transgenic animals lies in their ability to simulate specific properties desired by researchers. However, there is often a need for the rapid production of transgenic animal models, especially in situations like a pandemic, as was evident during COVID-19. An important tool for transgenesis is the adeno-associated virus. The genome of adeno-associated virus serves as a convenient expression cassette for delivering various DNA constructs into cells, and this method has proven effective in practice. This review analyzes the features of the adeno-associated virus genome that make it an advantageous vector for transgenesis. Additionally, examples of utilizing adeno-associated viral vectors to create animal models for hereditary, oncological, and viral human diseases are provided. |
| format | Article |
| id | doaj-art-f19d384675cd4e7882925733ca19f261 |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-f19d384675cd4e7882925733ca19f2612025-02-12T04:10:58ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-02-011110.3389/fmed.2024.14996051499605AAV-based vectors for human diseases modeling in laboratory animalsTimur I. Aliev0Dmitry V. Yudkin1Department of Natural Sciences, Novosibirsk State University, Novosibirsk, RussiaFederal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, RussiaThe development of therapeutic drugs and vaccines requires the availability of appropriate model animals that replicate the pathogenesis of human diseases. Both native and transgenic animals can be utilized as models. The advantage of transgenic animals lies in their ability to simulate specific properties desired by researchers. However, there is often a need for the rapid production of transgenic animal models, especially in situations like a pandemic, as was evident during COVID-19. An important tool for transgenesis is the adeno-associated virus. The genome of adeno-associated virus serves as a convenient expression cassette for delivering various DNA constructs into cells, and this method has proven effective in practice. This review analyzes the features of the adeno-associated virus genome that make it an advantageous vector for transgenesis. Additionally, examples of utilizing adeno-associated viral vectors to create animal models for hereditary, oncological, and viral human diseases are provided.https://www.frontiersin.org/articles/10.3389/fmed.2024.1499605/fulladeno-associated virustransgenesisanimal modelshuman diseasesgene therapy |
| spellingShingle | Timur I. Aliev Dmitry V. Yudkin AAV-based vectors for human diseases modeling in laboratory animals Frontiers in Medicine adeno-associated virus transgenesis animal models human diseases gene therapy |
| title | AAV-based vectors for human diseases modeling in laboratory animals |
| title_full | AAV-based vectors for human diseases modeling in laboratory animals |
| title_fullStr | AAV-based vectors for human diseases modeling in laboratory animals |
| title_full_unstemmed | AAV-based vectors for human diseases modeling in laboratory animals |
| title_short | AAV-based vectors for human diseases modeling in laboratory animals |
| title_sort | aav based vectors for human diseases modeling in laboratory animals |
| topic | adeno-associated virus transgenesis animal models human diseases gene therapy |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2024.1499605/full |
| work_keys_str_mv | AT timurialiev aavbasedvectorsforhumandiseasesmodelinginlaboratoryanimals AT dmitryvyudkin aavbasedvectorsforhumandiseasesmodelinginlaboratoryanimals |