Salivary Levels of Interleukin-17 in Iranian Patients With Systemic Sclerosis
Systemic sclerosis (SSc) is a rare immune-mediated rheumatic disease in which the skin, muscles, blood vessels, and internal organs are damaged through chronic inflammation. Interleukin-17 (IL-17) is a potent pro-inflammatory cytokine produced by T helper 17 (Th17) cells, and plays a critical role...
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Tehran University of Medical Sciences
2024-12-01
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| Series: | Acta Medica Iranica |
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| Online Access: | https://acta.tums.ac.ir/index.php/acta/article/view/10559 |
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| author | Ali Tadayon Javad Moayedi Mohamad Ali Nazarinia Mahyar Malekzadeh Sara Kazemi Maryam Mardani |
| author_facet | Ali Tadayon Javad Moayedi Mohamad Ali Nazarinia Mahyar Malekzadeh Sara Kazemi Maryam Mardani |
| author_sort | Ali Tadayon |
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Systemic sclerosis (SSc) is a rare immune-mediated rheumatic disease in which the skin, muscles, blood vessels, and internal organs are damaged through chronic inflammation. Interleukin-17 (IL-17) is a potent pro-inflammatory cytokine produced by T helper 17 (Th17) cells, and plays a critical role in many inflammatory conditions. This study aims to assess the salivary IL-17 levels in Iranian patients with SSc. In this cross-sectional study, unstimulated saliva samples were collected from patients with SSc (n=80) and age- and sex- matched healthy individuals (n=80). The salivary levels of IL-17 in all samples were measured using a commercially available enzyme–linked immunosorbent assay (ELISA) kit. The mean salivary levels of IL-17 in patients with SSc were significantly higher than the control group (199.6±38.9 pg/mL vs. 112.7±39.4 pg/mL, P<0.0001). IL-17 in the patient group had a significant positive correlation with anticentromere antibody (ACA) concentration (r=0.875, P<0.0001). The salivary levels of IL-17 showed no significant differences between males and females. Based on the results, salivary levels of IL-17 could be considered a good marker to differentiate patients with SSc from healthy subjects. Considering the role of this inflammatory cytokine in tissue inflammation and its association with ACA concentration, IL-17 might be involved in the pathogenesis of SSc; however, further comprehensive studies are needed to confirm our findings.
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| format | Article |
| id | doaj-art-f1927d7f5063414f8259f56dbe07874a |
| institution | Kabale University |
| issn | 0044-6025 1735-9694 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Acta Medica Iranica |
| spelling | doaj-art-f1927d7f5063414f8259f56dbe07874a2025-02-09T08:50:58ZengTehran University of Medical SciencesActa Medica Iranica0044-60251735-96942024-12-0162410.18502/acta.v62i4.17431Salivary Levels of Interleukin-17 in Iranian Patients With Systemic SclerosisAli Tadayon0Javad Moayedi1Mohamad Ali Nazarinia2Mahyar Malekzadeh3Sara Kazemi4Maryam Mardani5Department of Surgery, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.Central Research Laboratory, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.Department of Internal Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.Department of Oral and Maxillofacial Medicine, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Oral and Maxillofacial Medicine, School of Dentistry, Oral and Dental Disease Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Systemic sclerosis (SSc) is a rare immune-mediated rheumatic disease in which the skin, muscles, blood vessels, and internal organs are damaged through chronic inflammation. Interleukin-17 (IL-17) is a potent pro-inflammatory cytokine produced by T helper 17 (Th17) cells, and plays a critical role in many inflammatory conditions. This study aims to assess the salivary IL-17 levels in Iranian patients with SSc. In this cross-sectional study, unstimulated saliva samples were collected from patients with SSc (n=80) and age- and sex- matched healthy individuals (n=80). The salivary levels of IL-17 in all samples were measured using a commercially available enzyme–linked immunosorbent assay (ELISA) kit. The mean salivary levels of IL-17 in patients with SSc were significantly higher than the control group (199.6±38.9 pg/mL vs. 112.7±39.4 pg/mL, P<0.0001). IL-17 in the patient group had a significant positive correlation with anticentromere antibody (ACA) concentration (r=0.875, P<0.0001). The salivary levels of IL-17 showed no significant differences between males and females. Based on the results, salivary levels of IL-17 could be considered a good marker to differentiate patients with SSc from healthy subjects. Considering the role of this inflammatory cytokine in tissue inflammation and its association with ACA concentration, IL-17 might be involved in the pathogenesis of SSc; however, further comprehensive studies are needed to confirm our findings. https://acta.tums.ac.ir/index.php/acta/article/view/10559Interleukin-17 (IL-17)SalivaSystemic sclerosis (SSc) |
| spellingShingle | Ali Tadayon Javad Moayedi Mohamad Ali Nazarinia Mahyar Malekzadeh Sara Kazemi Maryam Mardani Salivary Levels of Interleukin-17 in Iranian Patients With Systemic Sclerosis Acta Medica Iranica Interleukin-17 (IL-17) Saliva Systemic sclerosis (SSc) |
| title | Salivary Levels of Interleukin-17 in Iranian Patients With Systemic Sclerosis |
| title_full | Salivary Levels of Interleukin-17 in Iranian Patients With Systemic Sclerosis |
| title_fullStr | Salivary Levels of Interleukin-17 in Iranian Patients With Systemic Sclerosis |
| title_full_unstemmed | Salivary Levels of Interleukin-17 in Iranian Patients With Systemic Sclerosis |
| title_short | Salivary Levels of Interleukin-17 in Iranian Patients With Systemic Sclerosis |
| title_sort | salivary levels of interleukin 17 in iranian patients with systemic sclerosis |
| topic | Interleukin-17 (IL-17) Saliva Systemic sclerosis (SSc) |
| url | https://acta.tums.ac.ir/index.php/acta/article/view/10559 |
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