Sociobiology meets oncology: unraveling altruistic cooperation in cancer cells and its implications
Abstract Altruism, an act of benefiting others at a cost to the self, challenges our understanding of evolution. This Perspective delves into the importance of altruism in cancer cells and its implications for therapy. Against the backdrop of existing knowledge on various social organisms found in n...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2025-01-01
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| Series: | Experimental and Molecular Medicine |
| Online Access: | https://doi.org/10.1038/s12276-024-01387-9 |
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| _version_ | 1823863232995000320 |
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| author | Muhammad Sufyan bin Masroni Evelyn Siew-Chuan Koay Victor Kwan Min Lee Siok Bian Ng Soo Yong Tan Karen Meiling Tan Marco Archetti Sai Mun Leong |
| author_facet | Muhammad Sufyan bin Masroni Evelyn Siew-Chuan Koay Victor Kwan Min Lee Siok Bian Ng Soo Yong Tan Karen Meiling Tan Marco Archetti Sai Mun Leong |
| author_sort | Muhammad Sufyan bin Masroni |
| collection | DOAJ |
| description | Abstract Altruism, an act of benefiting others at a cost to the self, challenges our understanding of evolution. This Perspective delves into the importance of altruism in cancer cells and its implications for therapy. Against the backdrop of existing knowledge on various social organisms found in nature, we explore the mechanisms underlying the manifestation of altruism within breast tumors, revealing a complex interplay of seemingly counteracting cancer signaling pathways and processes that orchestrate the delicate balance between cost and benefit underlying altruistic cooperation. We also discuss how evolutionary game theory, coupled with contemporary molecular tools, may shed light on understudied mechanisms governing the dynamics of altruistic cooperation in cancer cells. Finally, we discuss how molecular insights gleaned from these mechanistic dissections may fuel advancements in our comprehension of altruism among cancer cells, with implications across multiple disciplines, offering innovative prospects for therapeutic strategies, molecular discoveries, and evolutionary investigations. |
| format | Article |
| id | doaj-art-f192463fa0c44977858cd265d39914e5 |
| institution | Kabale University |
| issn | 2092-6413 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Experimental and Molecular Medicine |
| spelling | doaj-art-f192463fa0c44977858cd265d39914e52025-02-09T12:14:21ZengNature Publishing GroupExperimental and Molecular Medicine2092-64132025-01-01571304010.1038/s12276-024-01387-9Sociobiology meets oncology: unraveling altruistic cooperation in cancer cells and its implicationsMuhammad Sufyan bin Masroni0Evelyn Siew-Chuan Koay1Victor Kwan Min Lee2Siok Bian Ng3Soo Yong Tan4Karen Meiling Tan5Marco Archetti6Sai Mun Leong7Department of Pathology, Yong Loo Lin School of Medicine, National University of SingaporeDepartment of Pathology, Yong Loo Lin School of Medicine, National University of SingaporeDepartment of Pathology, Yong Loo Lin School of Medicine, National University of SingaporeDepartment of Pathology, Yong Loo Lin School of Medicine, National University of SingaporeDepartment of Pathology, Yong Loo Lin School of Medicine, National University of SingaporeSingapore Institute for Clinical Sciences, Brenner Centre for Molecular MedicineDepartment of Biology, Pennsylvania State UniversityDepartment of Pathology, Yong Loo Lin School of Medicine, National University of SingaporeAbstract Altruism, an act of benefiting others at a cost to the self, challenges our understanding of evolution. This Perspective delves into the importance of altruism in cancer cells and its implications for therapy. Against the backdrop of existing knowledge on various social organisms found in nature, we explore the mechanisms underlying the manifestation of altruism within breast tumors, revealing a complex interplay of seemingly counteracting cancer signaling pathways and processes that orchestrate the delicate balance between cost and benefit underlying altruistic cooperation. We also discuss how evolutionary game theory, coupled with contemporary molecular tools, may shed light on understudied mechanisms governing the dynamics of altruistic cooperation in cancer cells. Finally, we discuss how molecular insights gleaned from these mechanistic dissections may fuel advancements in our comprehension of altruism among cancer cells, with implications across multiple disciplines, offering innovative prospects for therapeutic strategies, molecular discoveries, and evolutionary investigations.https://doi.org/10.1038/s12276-024-01387-9 |
| spellingShingle | Muhammad Sufyan bin Masroni Evelyn Siew-Chuan Koay Victor Kwan Min Lee Siok Bian Ng Soo Yong Tan Karen Meiling Tan Marco Archetti Sai Mun Leong Sociobiology meets oncology: unraveling altruistic cooperation in cancer cells and its implications Experimental and Molecular Medicine |
| title | Sociobiology meets oncology: unraveling altruistic cooperation in cancer cells and its implications |
| title_full | Sociobiology meets oncology: unraveling altruistic cooperation in cancer cells and its implications |
| title_fullStr | Sociobiology meets oncology: unraveling altruistic cooperation in cancer cells and its implications |
| title_full_unstemmed | Sociobiology meets oncology: unraveling altruistic cooperation in cancer cells and its implications |
| title_short | Sociobiology meets oncology: unraveling altruistic cooperation in cancer cells and its implications |
| title_sort | sociobiology meets oncology unraveling altruistic cooperation in cancer cells and its implications |
| url | https://doi.org/10.1038/s12276-024-01387-9 |
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