Linking Neuroinflammation and Neurodegeneration in Parkinson’s Disease
Neurodegenerative diseases such as Parkinson’s disease (PD) and Alzheimer’s disease (AD) impose a pressing burden on our developed and consequently aging society. Misfolded protein aggregates are a critical aspect of several neurodegenerative diseases. Nevertheless, several questions remain unanswer...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2018/4784268 |
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| author | Géraldine Gelders Veerle Baekelandt Anke Van der Perren |
| author_facet | Géraldine Gelders Veerle Baekelandt Anke Van der Perren |
| author_sort | Géraldine Gelders |
| collection | DOAJ |
| description | Neurodegenerative diseases such as Parkinson’s disease (PD) and Alzheimer’s disease (AD) impose a pressing burden on our developed and consequently aging society. Misfolded protein aggregates are a critical aspect of several neurodegenerative diseases. Nevertheless, several questions remain unanswered regarding the role of misfolded protein aggregates and the cause of neuronal cell death. Recently, it has been postulated that neuroinflammatory processes might play a crucial role in the pathogenesis of PD. Numerous postmortem, brain imaging, epidemiological, and animal studies have documented the involvement of the innate and adaptive immunity in neurodegeneration. Whether these inflammatory processes are directly involved in the etiology of PD or represent secondary consequences of nigrostriatal pathway injury is the subject of intensive research. Immune alterations in response to extracellular α-synuclein may play a critical role in modulating Parkinson’s disease progression. In this review, we address the current concept of neuroinflammation and its involvement in PD-associated neurodegeneration. |
| format | Article |
| id | doaj-art-f18d7e024b5443bea9b3a59910c1b0af |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-f18d7e024b5443bea9b3a59910c1b0af2025-02-03T01:11:26ZengWileyJournal of Immunology Research2314-88612314-71562018-01-01201810.1155/2018/47842684784268Linking Neuroinflammation and Neurodegeneration in Parkinson’s DiseaseGéraldine Gelders0Veerle Baekelandt1Anke Van der Perren2Laboratory for Neurobiology and Gene Therapy, Department of Neurosciences, KU Leuven, Leuven, BelgiumLaboratory for Neurobiology and Gene Therapy, Department of Neurosciences, KU Leuven, Leuven, BelgiumLaboratory for Neurobiology and Gene Therapy, Department of Neurosciences, KU Leuven, Leuven, BelgiumNeurodegenerative diseases such as Parkinson’s disease (PD) and Alzheimer’s disease (AD) impose a pressing burden on our developed and consequently aging society. Misfolded protein aggregates are a critical aspect of several neurodegenerative diseases. Nevertheless, several questions remain unanswered regarding the role of misfolded protein aggregates and the cause of neuronal cell death. Recently, it has been postulated that neuroinflammatory processes might play a crucial role in the pathogenesis of PD. Numerous postmortem, brain imaging, epidemiological, and animal studies have documented the involvement of the innate and adaptive immunity in neurodegeneration. Whether these inflammatory processes are directly involved in the etiology of PD or represent secondary consequences of nigrostriatal pathway injury is the subject of intensive research. Immune alterations in response to extracellular α-synuclein may play a critical role in modulating Parkinson’s disease progression. In this review, we address the current concept of neuroinflammation and its involvement in PD-associated neurodegeneration.http://dx.doi.org/10.1155/2018/4784268 |
| spellingShingle | Géraldine Gelders Veerle Baekelandt Anke Van der Perren Linking Neuroinflammation and Neurodegeneration in Parkinson’s Disease Journal of Immunology Research |
| title | Linking Neuroinflammation and Neurodegeneration in Parkinson’s Disease |
| title_full | Linking Neuroinflammation and Neurodegeneration in Parkinson’s Disease |
| title_fullStr | Linking Neuroinflammation and Neurodegeneration in Parkinson’s Disease |
| title_full_unstemmed | Linking Neuroinflammation and Neurodegeneration in Parkinson’s Disease |
| title_short | Linking Neuroinflammation and Neurodegeneration in Parkinson’s Disease |
| title_sort | linking neuroinflammation and neurodegeneration in parkinson s disease |
| url | http://dx.doi.org/10.1155/2018/4784268 |
| work_keys_str_mv | AT geraldinegelders linkingneuroinflammationandneurodegenerationinparkinsonsdisease AT veerlebaekelandt linkingneuroinflammationandneurodegenerationinparkinsonsdisease AT ankevanderperren linkingneuroinflammationandneurodegenerationinparkinsonsdisease |