The early warning paradox

Machine learning models in healthcare aim to predict critical outcomes but often overlook existing Early Warning Systems’ impact. Using data from King’s College Hospital, we demonstrate how current evaluation methods can lead to paradoxical results. We discuss challenges in developing ML models from...

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Main Authors: Hugh Logan Ellis, Edward Palmer, James T. Teo, Martin Whyte, Kenneth Rockwood, Zina Ibrahim
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:npj Digital Medicine
Online Access:https://doi.org/10.1038/s41746-024-01408-x
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author Hugh Logan Ellis
Edward Palmer
James T. Teo
Martin Whyte
Kenneth Rockwood
Zina Ibrahim
author_facet Hugh Logan Ellis
Edward Palmer
James T. Teo
Martin Whyte
Kenneth Rockwood
Zina Ibrahim
author_sort Hugh Logan Ellis
collection DOAJ
description Machine learning models in healthcare aim to predict critical outcomes but often overlook existing Early Warning Systems’ impact. Using data from King’s College Hospital, we demonstrate how current evaluation methods can lead to paradoxical results. We discuss challenges in developing ML models from retrospective data and propose a novel approach focused on identifying when patients enter a ‘risk state’ through latent health representations, potentially transforming clinical decision-making.
format Article
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institution Kabale University
issn 2398-6352
language English
publishDate 2025-02-01
publisher Nature Portfolio
record_format Article
series npj Digital Medicine
spelling doaj-art-f18ce6de300947509efb06babf9509a82025-02-09T12:55:38ZengNature Portfolionpj Digital Medicine2398-63522025-02-01811210.1038/s41746-024-01408-xThe early warning paradoxHugh Logan Ellis0Edward Palmer1James T. Teo2Martin Whyte3Kenneth Rockwood4Zina Ibrahim5King’s College LondonInstitute of Health InformaticsKing’s College Hospital NHS Foundation TrustUniversity of SurreyDalhousie UniversityKing’s College LondonMachine learning models in healthcare aim to predict critical outcomes but often overlook existing Early Warning Systems’ impact. Using data from King’s College Hospital, we demonstrate how current evaluation methods can lead to paradoxical results. We discuss challenges in developing ML models from retrospective data and propose a novel approach focused on identifying when patients enter a ‘risk state’ through latent health representations, potentially transforming clinical decision-making.https://doi.org/10.1038/s41746-024-01408-x
spellingShingle Hugh Logan Ellis
Edward Palmer
James T. Teo
Martin Whyte
Kenneth Rockwood
Zina Ibrahim
The early warning paradox
npj Digital Medicine
title The early warning paradox
title_full The early warning paradox
title_fullStr The early warning paradox
title_full_unstemmed The early warning paradox
title_short The early warning paradox
title_sort early warning paradox
url https://doi.org/10.1038/s41746-024-01408-x
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