Methotrexate induced lung injury in a patient with primary CNS lymphoma: A case report
Methotrexate is an antimetabolite commonly used in clinical practice for a variety of indications ranging from rheumatoid arthritis and other connective tissue disorders to high dose regimens in many malignancies. This folate antagonist has got a spectrum of toxicities among which gastrointestinal e...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2012-04-01
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| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.mjhid.org/index.php/mjhid/article/view/388 |
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| author | puneet chhabra arjun dutt law dr vikas suri dr pankaj malhotra dr subhash varma |
| author_facet | puneet chhabra arjun dutt law dr vikas suri dr pankaj malhotra dr subhash varma |
| author_sort | puneet chhabra |
| collection | DOAJ |
| description | Methotrexate is an antimetabolite commonly used in clinical practice for a variety of indications ranging from rheumatoid arthritis and other connective tissue disorders to high dose regimens in many malignancies. This folate antagonist has got a spectrum of toxicities among which gastrointestinal effects predominate . Lung injury is a well described but rare event and has been reported most often in patients who have been on long term oral therapy for rheumatic disorders. Acute lung injury in a patient receiving a high dose regimen for haematological malignancies has not been reported previously. We present one such case of methotrexate related acute lung injury in a patient of primary CNS lymphoma receiving high dose methotrexate. |
| format | Article |
| id | doaj-art-f1819b40f57b4172a1e189a0d0df1def |
| institution | Kabale University |
| issn | 2035-3006 |
| language | English |
| publishDate | 2012-04-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Mediterranean Journal of Hematology and Infectious Diseases |
| spelling | doaj-art-f1819b40f57b4172a1e189a0d0df1def2025-01-02T11:13:04ZengPAGEPress PublicationsMediterranean Journal of Hematology and Infectious Diseases2035-30062012-04-0141e2012020e201202010.4084/mjhid.2012.020280Methotrexate induced lung injury in a patient with primary CNS lymphoma: A case reportpuneet chhabra0arjun dutt law1dr vikas suri2dr pankaj malhotra3dr subhash varma4junior resident department of internal medicine PGIMER CHANDIGARH 160012senior resident department of internal medicine PGIMER CHANDIGARH 160012assistant professor department of internal medicine PGIMER CHANDIGARH 160012additional professor department of internal medicine PGIMER CHANDIGARH 160012HOD and professor department of internal medicine PGIMER chandigarhMethotrexate is an antimetabolite commonly used in clinical practice for a variety of indications ranging from rheumatoid arthritis and other connective tissue disorders to high dose regimens in many malignancies. This folate antagonist has got a spectrum of toxicities among which gastrointestinal effects predominate . Lung injury is a well described but rare event and has been reported most often in patients who have been on long term oral therapy for rheumatic disorders. Acute lung injury in a patient receiving a high dose regimen for haematological malignancies has not been reported previously. We present one such case of methotrexate related acute lung injury in a patient of primary CNS lymphoma receiving high dose methotrexate.http://www.mjhid.org/index.php/mjhid/article/view/388methotrexate, lung in jury, primary CNS lymphoma |
| spellingShingle | puneet chhabra arjun dutt law dr vikas suri dr pankaj malhotra dr subhash varma Methotrexate induced lung injury in a patient with primary CNS lymphoma: A case report Mediterranean Journal of Hematology and Infectious Diseases methotrexate, lung in jury, primary CNS lymphoma |
| title | Methotrexate induced lung injury in a patient with primary CNS lymphoma: A case report |
| title_full | Methotrexate induced lung injury in a patient with primary CNS lymphoma: A case report |
| title_fullStr | Methotrexate induced lung injury in a patient with primary CNS lymphoma: A case report |
| title_full_unstemmed | Methotrexate induced lung injury in a patient with primary CNS lymphoma: A case report |
| title_short | Methotrexate induced lung injury in a patient with primary CNS lymphoma: A case report |
| title_sort | methotrexate induced lung injury in a patient with primary cns lymphoma a case report |
| topic | methotrexate, lung in jury, primary CNS lymphoma |
| url | http://www.mjhid.org/index.php/mjhid/article/view/388 |
| work_keys_str_mv | AT puneetchhabra methotrexateinducedlunginjuryinapatientwithprimarycnslymphomaacasereport AT arjunduttlaw methotrexateinducedlunginjuryinapatientwithprimarycnslymphomaacasereport AT drvikassuri methotrexateinducedlunginjuryinapatientwithprimarycnslymphomaacasereport AT drpankajmalhotra methotrexateinducedlunginjuryinapatientwithprimarycnslymphomaacasereport AT drsubhashvarma methotrexateinducedlunginjuryinapatientwithprimarycnslymphomaacasereport |