Inhibition of A2B Adenosine Receptor Attenuates Intestinal Injury in a Rat Model of Necrotizing Enterocolitis

Inhibition of A2B Adenosine Receptor Attenuates Intestinal Injury in a Rat Model of Necrotizing Enterocolitis

Necrotizing enterocolitis (NEC) is a lethal gastrointestinal tract disease that occurs in premature infants. Adenosine receptor A2B (A2BR) regulates the inflammation cytokine secretion and immune cell infiltration in the colonic pathophysiology conditions. In the present study, we aim to determine t...

Full description

Saved in:

Bibliographic Details
Main Authors:	Lie Huang, Juan Fan, Yan-Xiang Chen, Jian-Hui Wang
Format:	Article
Language:	English
Published:	Wiley 2020-01-01
Series:	Mediators of Inflammation
Online Access:	http://dx.doi.org/10.1155/2020/1562973
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Necrotizing enterocolitis
by: Guillermo Bauzá López, et al.
Published: (2005-12-01)

Effect of gestational age on clinical features in necrotizing enterocolitis-associated intestinal perforation
by: Minming Chen, et al.
Published: (2025-01-01)

Sulforaphane Ameliorates the Intestinal Injury in Necrotizing Enterocolitis by Regulating the PI3K/Akt/GSK-3β Signaling Pathway
by: Zhong-Kun Bao, et al.
Published: (2022-01-01)

Gastrocolic fistula after neonatal necrotizing enterocolitis
by: Gang Wen, et al.
Published: (2025-02-01)

Innate Immune Signaling in the Pathogenesis of Necrotizing Enterocolitis
by: David J. Hackam, et al.
Published: (2013-01-01)

Intracardiac air bubbles in a neonate with necrotizing enterocolitis
by: Yu Fukushima, et al.
Published: (2025-01-01)

The Coincidence of Necrotizing Enterocolitis and Rotavirus Infections and Potential Associations with Cytokines
by: Efsun Sızmaz, et al.
Published: (2012-01-01)

Urinary Intestinal Fatty Acid-Binding Protein Can Distinguish Necrotizing Enterocolitis from Sepsis in Early Stage of the Disease
by: Stepan Coufal, et al.
Published: (2016-01-01)

Digging deeper into necrotizing enterocolitis: bridging clinical, microbial, and molecular perspectives
by: Deshuang Zhang, et al.
Published: (2025-12-01)

Necrotizing enterocolitis in premature infants: the importance of risk factors in its development
by: I.I. Huseynova, et al.
Published: (2024-09-01)

Bowel Perforation in Premature Infants with Necrotizing Enterocolitis: Risk Factors and Outcomes
by: Lingling Yu, et al.
Published: (2016-01-01)

Clinical value of quantitative echocardiographic features in preterm infants with necrotizing enterocolitis
by: Wenmei li, et al.
Published: (2025-01-01)

Therapeutic Drug Monitoring of Meropenem in Neonate with Necrotizing Enterocolitis: A Challenge
by: Steven De Keukeleire, et al.
Published: (2016-01-01)

Analysis of agreement between specialists for the evaluation of radiological findings of necrotizing enterocolitis
by: Erica Cristina Scarpa, et al.
Published: (2025-01-01)

Adenosine Receptors and Wound Healing
by: Bruce N. Cronstein
Published: (2004-01-01)

A retrospective cohort study of the application of Santulli enterostomy in neonatal necrotizing enterocolitis
by: Zhe Fu, et al.
Published: (2025-01-01)

Neonatal necrotizing enterocolitis complicated by glutaric acidemia type II: a case report
by: Yuli Zhang, et al.
Published: (2025-02-01)

Adenosine A2A Receptors Modulate Acute Injury and Neuroinflammation in Brain Ischemia
by: Felicita Pedata, et al.
Published: (2014-01-01)

Lactate/albumin ratio as a prognostic biomarker for in-hospital mortality in pediatric patients with necrotizing enterocolitis
by: Ban Li, et al.
Published: (2025-02-01)

Zerumbone Attenuates the Severity of Acute Necrotizing Pancreatitis and Pancreatitis-Induced Hepatic Injury
by: Deng Wenhong, et al.
Published: (2012-01-01)

Glycyrrhizin Attenuates Toll Like Receptor-2, -4 and Experimental Vasospasm in a Rat Model
by: Chih-Zen Chang, et al.
Published: (2014-01-01)

Molecular Vibration-Activity Relationship in the Agonism of Adenosine Receptors
by: Hyun Keun Chee, et al.
Published: (2013-12-01)

Inhibition of Endothelial–Mesenchymal Transition Mediated by Activin Receptor Type IIA Attenuates Valvular Injury Induced by Group A Streptococcus in Lewis Rats
by: Zirong Lu, et al.
Published: (2025-01-01)

Inhibition of TLR4 Signalling-Induced Inflammation Attenuates Secondary Injury after Diffuse Axonal Injury in Rats
by: Yonglin Zhao, et al.
Published: (2016-01-01)

Corrigendum to “Hydrogen-Rich Saline Attenuates Cardiac and Hepatic Injury in Doxorubicin Rat Model by Inhibiting Inflammation and Apoptosis”
by: Yunan Gao, et al.
Published: (2017-01-01)

Activation of Adenosine A3 Receptor Alleviates TNF-α-Induced Inflammation through Inhibition of the NF-κB Signaling Pathway in Human Colonic Epithelial Cells
by: Tianhua Ren, et al.
Published: (2014-01-01)

Anesthetic Isoflurane Posttreatment Attenuates Experimental Lung Injury by Inhibiting Inflammation and Apoptosis
by: Jun-tang Li, et al.
Published: (2013-01-01)

Urinary I-FABP, L-FABP, TFF-3, and SAA Can Diagnose and Predict the Disease Course in Necrotizing Enterocolitis at the Early Stage of Disease
by: Stepan Coufal, et al.
Published: (2020-01-01)

Tanshinone IIA Sodium Sulfonate Attenuates LPS-Induced Intestinal Injury in Mice
by: Xin-Jing Yang, et al.
Published: (2018-01-01)

Risedronate Attenuates Podocyte Injury in Phosphate Transporter-Overexpressing Rats
by: Yohei Asada, et al.
Published: (2019-01-01)

DEmiRNA-mRNA regulatory network reveals miR‐122-5p as a regulatory factor of arginine metabolism in necrotizing enterocolitis
by: Zhili Ding, et al.
Published: (2025-01-01)

Hyperbaric oxygen therapy attenuates heatstroke-induced hippocampal injury by inhibiting microglial pyroptosis
by: Ancong Xu, et al.
Published: (2024-12-01)

Melatonin Reduces Inflammatory Injury Through Inhibiting NF-κB Activation in Rats With Colitis
by: Jun-Hua Li, et al.
Published: (2005-01-01)

Illuminating the impact of CD38-induced adenosine formation in B-cell lymphoma
by: Shams ElDoha Galal ElDin Zaiema, et al.
Published: (2025-01-01)

Effects of Lupeol on Intestinal Anastomosis After Experimental Intestinal Ischemia-Reperfusion Injury in Rats
by: Kaya C, et al.
Published: (2025-01-01)

Yunvjian decoction attenuates lipopolysaccharide-induced acute lung injury by inhibiting NF-κB/NLRP3 pathway and pyroptosis
by: Fanxuan Zhang, et al.
Published: (2025-01-01)

Recovery of the Cell Cycle Inhibition in CCl4-Induced Cirrhosis by the Adenosine Derivative IFC-305
by: Victoria Chagoya de Sánchez, et al.
Published: (2012-01-01)

Inhibition of P38 MAPK Downregulates the Expression of IL-1β to Protect Lung from Acute Injury in Intestinal Ischemia Reperfusion Rats
by: De-Yi Zheng, et al.
Published: (2016-01-01)

Exemestane Attenuates Hepatic Fibrosis in Rats by Inhibiting Activation of Hepatic Stellate Cells and Promoting the Secretion of Interleukin 10
by: Ya-Hui Wang, et al.
Published: (2017-01-01)

Alpha-Lipoic Acid Attenuates Cerebral Ischemia and Reperfusion Injury via Insulin Receptor and PI3K/Akt-Dependent Inhibition of NADPH Oxidase
by: Yinhua Dong, et al.
Published: (2015-01-01)