Phenotypic Changes in Subpopulations of Human NK and NKT Cells Induced
The article studies the effect of sulfated polysaccharide extracted from brown algae Fucus evanescens(fucoidan) and the product of its enzymatic transformation on human NK and NKT cells. Significant phenotypic changes in NK and NKT cells were recorded as a result of incubation of whole blood with po...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
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LLC "Publishing House OKI"
2020-05-01
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| Series: | Антибиотики и Химиотерапия |
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| Online Access: | https://www.antibiotics-chemotherapy.ru/jour/article/view/173 |
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| author | T. P. Smolina T. A. Kuznetsova L. A. Ivanushko A. K. Gazha A. S. Silchenko N. N. Besednova |
| author_facet | T. P. Smolina T. A. Kuznetsova L. A. Ivanushko A. K. Gazha A. S. Silchenko N. N. Besednova |
| author_sort | T. P. Smolina |
| collection | DOAJ |
| description | The article studies the effect of sulfated polysaccharide extracted from brown algae Fucus evanescens(fucoidan) and the product of its enzymatic transformation on human NK and NKT cells. Significant phenotypic changes in NK and NKT cells were recorded as a result of incubation of whole blood with polysaccharides. This was manifested in an increase in the expression of the activation molecules CD69, CD25, HLA-DR and the degranulation marker CD107a on NK and NKT cells, as well as CD8 molecules on NK cells. The effect of the enzymatic transformation product was significantly more pronounced compared to the native polysaccharide only in relation to the expression of CD69. |
| format | Article |
| id | doaj-art-f16bd564e3674413b4ffdebe0142205c |
| institution | DOAJ |
| issn | 0235-2990 |
| language | Russian |
| publishDate | 2020-05-01 |
| publisher | LLC "Publishing House OKI" |
| record_format | Article |
| series | Антибиотики и Химиотерапия |
| spelling | doaj-art-f16bd564e3674413b4ffdebe0142205c2025-08-20T03:20:32ZrusLLC "Publishing House OKI"Антибиотики и Химиотерапия0235-29902020-05-01649-1037891Phenotypic Changes in Subpopulations of Human NK and NKT Cells InducedT. P. Smolina0T. A. Kuznetsova1L. A. Ivanushko2A. K. Gazha3A. S. Silchenko4N. N. Besednova5Somov Institute of Epidemiology and MicrobiologySomov Institute of Epidemiology and MicrobiologySomov Institute of Epidemiology and MicrobiologySomov Institute of Epidemiology and MicrobiologyG. B. Elyakov Pacific Institute of Bioorganic ChemistrySomov Institute of Epidemiology and MicrobiologyThe article studies the effect of sulfated polysaccharide extracted from brown algae Fucus evanescens(fucoidan) and the product of its enzymatic transformation on human NK and NKT cells. Significant phenotypic changes in NK and NKT cells were recorded as a result of incubation of whole blood with polysaccharides. This was manifested in an increase in the expression of the activation molecules CD69, CD25, HLA-DR and the degranulation marker CD107a on NK and NKT cells, as well as CD8 molecules on NK cells. The effect of the enzymatic transformation product was significantly more pronounced compared to the native polysaccharide only in relation to the expression of CD69.https://www.antibiotics-chemotherapy.ru/jour/article/view/173sulfated polysaccharides, fucoidan, enzymatic transformation of fucoidan, innate immunity, activation markers, nk cells, nkt cells |
| spellingShingle | T. P. Smolina T. A. Kuznetsova L. A. Ivanushko A. K. Gazha A. S. Silchenko N. N. Besednova Phenotypic Changes in Subpopulations of Human NK and NKT Cells Induced Антибиотики и Химиотерапия sulfated polysaccharides, fucoidan, enzymatic transformation of fucoidan, innate immunity, activation markers, nk cells, nkt cells |
| title | Phenotypic Changes in Subpopulations of Human NK and NKT Cells Induced |
| title_full | Phenotypic Changes in Subpopulations of Human NK and NKT Cells Induced |
| title_fullStr | Phenotypic Changes in Subpopulations of Human NK and NKT Cells Induced |
| title_full_unstemmed | Phenotypic Changes in Subpopulations of Human NK and NKT Cells Induced |
| title_short | Phenotypic Changes in Subpopulations of Human NK and NKT Cells Induced |
| title_sort | phenotypic changes in subpopulations of human nk and nkt cells induced |
| topic | sulfated polysaccharides, fucoidan, enzymatic transformation of fucoidan, innate immunity, activation markers, nk cells, nkt cells |
| url | https://www.antibiotics-chemotherapy.ru/jour/article/view/173 |
| work_keys_str_mv | AT tpsmolina phenotypicchangesinsubpopulationsofhumannkandnktcellsinduced AT takuznetsova phenotypicchangesinsubpopulationsofhumannkandnktcellsinduced AT laivanushko phenotypicchangesinsubpopulationsofhumannkandnktcellsinduced AT akgazha phenotypicchangesinsubpopulationsofhumannkandnktcellsinduced AT assilchenko phenotypicchangesinsubpopulationsofhumannkandnktcellsinduced AT nnbesednova phenotypicchangesinsubpopulationsofhumannkandnktcellsinduced |