Mesenchymal Stem Cells in Renal Fibrosis: The Flame of Cytotherapy
Renal fibrosis, as the fundamental pathological process of chronic kidney disease (CKD), is a pathologic extension of the normal wound healing process characterized by endothelium injury, myofibroblast activation, macrophage migration, inflammatory signaling stimulation, matrix deposition, and remod...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2019/8387350 |
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| author | Quan Zhuang Ruoyu Ma Yanshuang Yin Tianhao Lan Meng Yu Yingzi Ming |
| author_facet | Quan Zhuang Ruoyu Ma Yanshuang Yin Tianhao Lan Meng Yu Yingzi Ming |
| author_sort | Quan Zhuang |
| collection | DOAJ |
| description | Renal fibrosis, as the fundamental pathological process of chronic kidney disease (CKD), is a pathologic extension of the normal wound healing process characterized by endothelium injury, myofibroblast activation, macrophage migration, inflammatory signaling stimulation, matrix deposition, and remodelling. Yet, the current method of treating renal fibrosis is fairly limited, including angiotensin-converting enzyme inhibition, angiotensin receptor blockade, optimal blood pressure control, and sodium bicarbonate for metabolic acidosis. MSCs are pluripotent adult stem cells that can differentiate into various types of tissue lineages, such as the cartilage (chondrocytes), bone (osteoblasts), fat (adipocytes), and muscle (myocytes). Because of their many advantages like ubiquitous sources, convenient procurement and collection, low immunogenicity, and low adverse effects, with their special identification markers, mesenchymal stem MSC-based therapy is getting more and more attention. Based on the mechanism of renal fibrosis, MSCs mostly participate throughout the renal fibrotic process. According to the latest and overall literature reviews, we aim to elucidate the antifibrotic mechanisms and effects of diverse sources of MSCs on renal fibrosis, assess their efficacy and safety in preliminarily clinical application, answer the controversial questions, and provide novel ideas into the MSC cellular therapy of renal fibrosis. |
| format | Article |
| id | doaj-art-f151d5b2731540569dd05f1240a20d0e |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-f151d5b2731540569dd05f1240a20d0e2025-02-03T01:24:26ZengWileyStem Cells International1687-966X1687-96782019-01-01201910.1155/2019/83873508387350Mesenchymal Stem Cells in Renal Fibrosis: The Flame of CytotherapyQuan Zhuang0Ruoyu Ma1Yanshuang Yin2Tianhao Lan3Meng Yu4Yingzi Ming5Transplantation Center of The 3rd Xiangya Hospital, Central South University, Changsha, Hunan 410013, ChinaXiangya School of Medicine, Central South University, Changsha, Hunan 410013, ChinaXiangya School of Medicine, Central South University, Changsha, Hunan 410013, ChinaXiangya School of Medicine, Central South University, Changsha, Hunan 410013, ChinaTransplantation Center of The 3rd Xiangya Hospital, Central South University, Changsha, Hunan 410013, ChinaTransplantation Center of The 3rd Xiangya Hospital, Central South University, Changsha, Hunan 410013, ChinaRenal fibrosis, as the fundamental pathological process of chronic kidney disease (CKD), is a pathologic extension of the normal wound healing process characterized by endothelium injury, myofibroblast activation, macrophage migration, inflammatory signaling stimulation, matrix deposition, and remodelling. Yet, the current method of treating renal fibrosis is fairly limited, including angiotensin-converting enzyme inhibition, angiotensin receptor blockade, optimal blood pressure control, and sodium bicarbonate for metabolic acidosis. MSCs are pluripotent adult stem cells that can differentiate into various types of tissue lineages, such as the cartilage (chondrocytes), bone (osteoblasts), fat (adipocytes), and muscle (myocytes). Because of their many advantages like ubiquitous sources, convenient procurement and collection, low immunogenicity, and low adverse effects, with their special identification markers, mesenchymal stem MSC-based therapy is getting more and more attention. Based on the mechanism of renal fibrosis, MSCs mostly participate throughout the renal fibrotic process. According to the latest and overall literature reviews, we aim to elucidate the antifibrotic mechanisms and effects of diverse sources of MSCs on renal fibrosis, assess their efficacy and safety in preliminarily clinical application, answer the controversial questions, and provide novel ideas into the MSC cellular therapy of renal fibrosis.http://dx.doi.org/10.1155/2019/8387350 |
| spellingShingle | Quan Zhuang Ruoyu Ma Yanshuang Yin Tianhao Lan Meng Yu Yingzi Ming Mesenchymal Stem Cells in Renal Fibrosis: The Flame of Cytotherapy Stem Cells International |
| title | Mesenchymal Stem Cells in Renal Fibrosis: The Flame of Cytotherapy |
| title_full | Mesenchymal Stem Cells in Renal Fibrosis: The Flame of Cytotherapy |
| title_fullStr | Mesenchymal Stem Cells in Renal Fibrosis: The Flame of Cytotherapy |
| title_full_unstemmed | Mesenchymal Stem Cells in Renal Fibrosis: The Flame of Cytotherapy |
| title_short | Mesenchymal Stem Cells in Renal Fibrosis: The Flame of Cytotherapy |
| title_sort | mesenchymal stem cells in renal fibrosis the flame of cytotherapy |
| url | http://dx.doi.org/10.1155/2019/8387350 |
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