From Lineage to Longevity: A Field Guide to the Key Players in Epigenetic Contribution to Offspring Health
Epidemiological evidence firmly supports the rationale that chronic diseases demonstrate a heritability component. Notwithstanding recent advances in genomic technologies, in a significant proportion of heritable diseases, a candidate gene of interest that explains the entire picture of heritability...
Saved in:
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-04-01
|
| Series: | Current Issues in Molecular Biology |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1467-3045/47/5/323 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850257369836027904 |
|---|---|
| author | Razia Zakarya |
| author_facet | Razia Zakarya |
| author_sort | Razia Zakarya |
| collection | DOAJ |
| description | Epidemiological evidence firmly supports the rationale that chronic diseases demonstrate a heritability component. Notwithstanding recent advances in genomic technologies, in a significant proportion of heritable diseases, a candidate gene of interest that explains the entire picture of heritability remains to be identified. Further epidemiological evidence points to environmental risk factors contributing to chronic disease prevalence and severity. The Developmental Origins of Health and Disease hypothesis points to epigenetics as the mechanism modulating gene–environment interactions to elicit disease. Yet the primary effector of epigenetic inheritance remains to be elucidated. This review focuses on key contributors to mammalian development and the epigenetic changes measured therein, to draw attention towards potential molecular candidates underpinning chronic disease heritability. |
| format | Article |
| id | doaj-art-f143452bb91d47ff86bb75b216f1df18 |
| institution | OA Journals |
| issn | 1467-3037 1467-3045 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Issues in Molecular Biology |
| spelling | doaj-art-f143452bb91d47ff86bb75b216f1df182025-08-20T01:56:25ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452025-04-0147532310.3390/cimb47050323From Lineage to Longevity: A Field Guide to the Key Players in Epigenetic Contribution to Offspring HealthRazia Zakarya0School of Life Sciences, University of Technology Sydney, Sydney 2007, AustraliaEpidemiological evidence firmly supports the rationale that chronic diseases demonstrate a heritability component. Notwithstanding recent advances in genomic technologies, in a significant proportion of heritable diseases, a candidate gene of interest that explains the entire picture of heritability remains to be identified. Further epidemiological evidence points to environmental risk factors contributing to chronic disease prevalence and severity. The Developmental Origins of Health and Disease hypothesis points to epigenetics as the mechanism modulating gene–environment interactions to elicit disease. Yet the primary effector of epigenetic inheritance remains to be elucidated. This review focuses on key contributors to mammalian development and the epigenetic changes measured therein, to draw attention towards potential molecular candidates underpinning chronic disease heritability.https://www.mdpi.com/1467-3045/47/5/323DNA methylationhistone modificationdevelopmentepigenetics |
| spellingShingle | Razia Zakarya From Lineage to Longevity: A Field Guide to the Key Players in Epigenetic Contribution to Offspring Health Current Issues in Molecular Biology DNA methylation histone modification development epigenetics |
| title | From Lineage to Longevity: A Field Guide to the Key Players in Epigenetic Contribution to Offspring Health |
| title_full | From Lineage to Longevity: A Field Guide to the Key Players in Epigenetic Contribution to Offspring Health |
| title_fullStr | From Lineage to Longevity: A Field Guide to the Key Players in Epigenetic Contribution to Offspring Health |
| title_full_unstemmed | From Lineage to Longevity: A Field Guide to the Key Players in Epigenetic Contribution to Offspring Health |
| title_short | From Lineage to Longevity: A Field Guide to the Key Players in Epigenetic Contribution to Offspring Health |
| title_sort | from lineage to longevity a field guide to the key players in epigenetic contribution to offspring health |
| topic | DNA methylation histone modification development epigenetics |
| url | https://www.mdpi.com/1467-3045/47/5/323 |
| work_keys_str_mv | AT raziazakarya fromlineagetolongevityafieldguidetothekeyplayersinepigeneticcontributiontooffspringhealth |