Mast cells boost anti-tumor potency of MAIT cells via inflammasome-dependent secretion of IL-18

Mast cells boost anti-tumor potency of MAIT cells via inflammasome-dependent secretion of IL-18

Abstract Mast cells (MC) serve as pivotal sentinels in the regulation of immune responses and inflammation, yet their function in lung adenocarcinoma (LUAD) remains largely neglected. To decode their heterogeneity, we perform single-cell transcriptomic analysis of LUAD-infiltrating MCs. Our study un...

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Main Authors: Fanfan Fan, Jun Wang, Kun Liu, Shiyue Zhang, Jian Gao, Xiongfei Li, Jiaqiang Ma, Yue Zhao, Teng Li, Han Su, Xinfeng Yang, Han Han, Qingyuan Huang, Yiliang Zhang, Yunjian Pan, Ting Ye, Hong Hu, Yihua Sun, Fei Li, Zhiwei Cao, Yang Zhang, Xiaoming Zhang, Haiquan Chen
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61324-w
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