Systematic and Targeted Prostate Biopsy: a Five-Year Experience in a High-Volume Center
Prostate biopsy is the gold standard diagnostic tool for prostate cancer. The number of targeted prostate biopsies based on multiparametric resonance imaging have increased in recent years, and this method is becoming increasingly utilized in patients in repeat biopsy settings, but also for biops...
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| Format: | Article |
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Sestre Milosrdnice University hospital, Institute of Clinical Medical Research
2024-01-01
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| Series: | Acta Clinica Croatica |
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| Online Access: | https://hrcak.srce.hr/file/466905 |
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| author | Toni Zekulić Tomislav Kuliš Tvrtko Hudolin Luka Penezić Jerko Anđelić Tomislav Sambolić Bojan Čikić Nikola Knežević Željko Kaštelan |
| author_facet | Toni Zekulić Tomislav Kuliš Tvrtko Hudolin Luka Penezić Jerko Anđelić Tomislav Sambolić Bojan Čikić Nikola Knežević Željko Kaštelan |
| author_sort | Toni Zekulić |
| collection | DOAJ |
| description | Prostate biopsy is the gold standard diagnostic tool for prostate cancer. The number
of targeted prostate biopsies based on multiparametric resonance imaging have increased in recent
years, and this method is becoming increasingly utilized in patients in repeat biopsy settings, but also
for biopsy-naive patients. The aim of this study was to analyze and present our results for the purpose
of self-control and education. In the time period between January 2018 and December 2022, there
were a total of 3385 prostate biopsies performed at the University Hospital Centre Zagreb. There were
2636 systematic (12 core) and 749 cognitive targeted biopsies, with an increasing trend in favor of
targeted biopsy. The positivity of systematic biopsy was 45%, whereas positivity for targeted biopsies
was 53.3%. The positivity of PI-RADS 3 lesions for targeted biopsies was 35%, 61% for PI-RADS
4, and 86% for PI-RADS 5. The median number of positive systematic cores was 3, and 4 cores for
targeted biopsies, while the median cancer core involvements were 30% for systematic and 60% for
targeted cores. In targeted cores, there was a higher percentage of ISUP grade 2 and 3 cancers when
compared with systematic cores. Targeted biopsy is a valuable addition to the standard systematic
biopsy in patients with suspicious lesions described on mpMRI. |
| format | Article |
| id | doaj-art-f13854baa3414d128fdb5b80bce1ebfa |
| institution | Kabale University |
| issn | 0353-9466 1333-9451 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Sestre Milosrdnice University hospital, Institute of Clinical Medical Research |
| record_format | Article |
| series | Acta Clinica Croatica |
| spelling | doaj-art-f13854baa3414d128fdb5b80bce1ebfa2024-12-09T13:33:31ZengSestre Milosrdnice University hospital, Institute of Clinical Medical ResearchActa Clinica Croatica0353-94661333-94512024-01-0163.Supplement 2222710.20471/acc.2024.63.s2.3Systematic and Targeted Prostate Biopsy: a Five-Year Experience in a High-Volume CenterToni Zekulić0Tomislav Kuliš1Tvrtko Hudolin2Luka Penezić3Jerko Anđelić4Tomislav Sambolić5Bojan Čikić6Nikola Knežević7Željko Kaštelan8Department of Urology, University Hospital Centre Zagreb, Zagreb, CroatiaDepartment of Urology, University Hospital Centre Zagreb, Zagreb, Croatia; University of Zagreb School of Medicine, Zagreb, CroatiaDepartment of Urology, University Hospital Centre Zagreb, Zagreb, Croatia; University of Zagreb School of Medicine, Zagreb, CroatiaDepartment of Urology, University Hospital Centre Zagreb, Zagreb, CroatiaDepartment of Urology, University Hospital Centre Zagreb, Zagreb, CroatiaDepartment of Urology, University Hospital Centre Zagreb, Zagreb, CroatiaDepartment of Urology, University Hospital Centre Zagreb, Zagreb, CroatiaDepartment of Urology, University Hospital Centre Zagreb, Zagreb, Croatia; University of Zagreb School of Medicine, Zagreb, CroatiaDepartment of Urology, University Hospital Centre Zagreb, Zagreb, Croatia; University of Zagreb School of Medicine, Zagreb, CroatiaProstate biopsy is the gold standard diagnostic tool for prostate cancer. The number of targeted prostate biopsies based on multiparametric resonance imaging have increased in recent years, and this method is becoming increasingly utilized in patients in repeat biopsy settings, but also for biopsy-naive patients. The aim of this study was to analyze and present our results for the purpose of self-control and education. In the time period between January 2018 and December 2022, there were a total of 3385 prostate biopsies performed at the University Hospital Centre Zagreb. There were 2636 systematic (12 core) and 749 cognitive targeted biopsies, with an increasing trend in favor of targeted biopsy. The positivity of systematic biopsy was 45%, whereas positivity for targeted biopsies was 53.3%. The positivity of PI-RADS 3 lesions for targeted biopsies was 35%, 61% for PI-RADS 4, and 86% for PI-RADS 5. The median number of positive systematic cores was 3, and 4 cores for targeted biopsies, while the median cancer core involvements were 30% for systematic and 60% for targeted cores. In targeted cores, there was a higher percentage of ISUP grade 2 and 3 cancers when compared with systematic cores. Targeted biopsy is a valuable addition to the standard systematic biopsy in patients with suspicious lesions described on mpMRI.https://hrcak.srce.hr/file/466905Prostate cancerProstate biopsyTargeted prostate biopsympMRI |
| spellingShingle | Toni Zekulić Tomislav Kuliš Tvrtko Hudolin Luka Penezić Jerko Anđelić Tomislav Sambolić Bojan Čikić Nikola Knežević Željko Kaštelan Systematic and Targeted Prostate Biopsy: a Five-Year Experience in a High-Volume Center Acta Clinica Croatica Prostate cancer Prostate biopsy Targeted prostate biopsy mpMRI |
| title | Systematic and Targeted Prostate Biopsy: a Five-Year Experience in a High-Volume Center |
| title_full | Systematic and Targeted Prostate Biopsy: a Five-Year Experience in a High-Volume Center |
| title_fullStr | Systematic and Targeted Prostate Biopsy: a Five-Year Experience in a High-Volume Center |
| title_full_unstemmed | Systematic and Targeted Prostate Biopsy: a Five-Year Experience in a High-Volume Center |
| title_short | Systematic and Targeted Prostate Biopsy: a Five-Year Experience in a High-Volume Center |
| title_sort | systematic and targeted prostate biopsy a five year experience in a high volume center |
| topic | Prostate cancer Prostate biopsy Targeted prostate biopsy mpMRI |
| url | https://hrcak.srce.hr/file/466905 |
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