PARP9-PARP13-PARP14 axis tunes colorectal cancer response to radiotherapy

PARP9-PARP13-PARP14 axis tunes colorectal cancer response to radiotherapy

Abstract Background Colorectal cancer (CRC) is the third most prevalent cancer worldwide. Despite substantial advancements in CRC therapy in recent years, ionizing radiation (IR) continues to be the predominant treatment for colon malignances. However, it still lacks the precision required for excel...

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Main Authors: Rimvile Prokarenkaite, Karolina Kuodyte, Greta Gudoityte, Elzbieta Budginaite, Daniel Naumovas, Egle Strainiene, Kristijonas Velickevicius, Audrius Dulskas, Ernestas Sileika, Jonas Venius, Virginijus Tunaitis, Augustas Pivoriunas, Vytaute Starkuviene, Vaidotas Stankevicius, Kestutis Suziedelis
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
3D cell culture
PARP9
PARP13
PARP14
Interferon stimulated genes
Radiotherapy
Online Access:https://doi.org/10.1186/s13046-025-03439-y
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