Intrahepatic Lipid Content and Insulin Resistance Are More Strongly Associated with Impaired NEFA Suppression after Oral Glucose Loading Than with Fasting NEFA Levels in Healthy Older Individuals
Introduction. The mechanisms underlying the association between insulin resistance and intrahepatic lipid (IHL) accumulation are not completely understood. We sought to determine whether this association was explained by differences in fasting non-esterified fatty acid (NEFA) levels and/or NEFA supp...
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| Format: | Article |
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2013-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2013/870487 |
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| author | Francis M. Finucane Stephen J. Sharp Mensud Hatunic Alison Sleigh Ema De Lucia Rolfe Avan Aihie Sayer Cyrus Cooper Simon J. Griffin David B. Savage Nicholas J. Wareham |
| author_facet | Francis M. Finucane Stephen J. Sharp Mensud Hatunic Alison Sleigh Ema De Lucia Rolfe Avan Aihie Sayer Cyrus Cooper Simon J. Griffin David B. Savage Nicholas J. Wareham |
| author_sort | Francis M. Finucane |
| collection | DOAJ |
| description | Introduction. The mechanisms underlying the association between insulin resistance and intrahepatic lipid (IHL) accumulation are not completely understood. We sought to determine whether this association was explained by differences in fasting non-esterified fatty acid (NEFA) levels and/or NEFA suppression after oral glucose loading. Materials and Methods. We performed a cross-sectional analysis of 70 healthy participants in the Hertfordshire Physical Activity Trial (39 males, age 71.3 ± 2.4 years) who underwent oral glucose tolerance testing with glucose, insulin, and NEFA levels measured over two hours. IHL was quantified with magnetic resonance spectroscopy. Insulin sensitivity was measured with the oral glucose insulin sensitivity (OGIS) model, the leptin: adiponectin ratio (LAR), and the homeostasis model assessment (HOMA). Results. Measures of insulin sensitivity were not associated with fasting NEFA levels, but OGIS was strongly associated with NEFA suppression at 30 minutes and strongly inversely associated with IHL. Moreover, LAR was strongly inversely associated with NEFA suppression and strongly associated with IHL. This latter association (beta = 1.11 [1.01, 1.21], ) was explained by reduced NEFA suppression ( after adjustment). Conclusions. Impaired postprandial NEFA suppression, but not fasting NEFA, contributes to the strong and well-established association between whole body insulin resistance and liver fat accumulation. |
| format | Article |
| id | doaj-art-f1258a5f005a484cb2c94e58e3ea88e2 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-f1258a5f005a484cb2c94e58e3ea88e22025-02-03T05:50:21ZengWileyInternational Journal of Endocrinology1687-83371687-83452013-01-01201310.1155/2013/870487870487Intrahepatic Lipid Content and Insulin Resistance Are More Strongly Associated with Impaired NEFA Suppression after Oral Glucose Loading Than with Fasting NEFA Levels in Healthy Older IndividualsFrancis M. Finucane0Stephen J. Sharp1Mensud Hatunic2Alison Sleigh3Ema De Lucia Rolfe4Avan Aihie Sayer5Cyrus Cooper6Simon J. Griffin7David B. Savage8Nicholas J. Wareham9MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, P.O. Box 285 Hills Road, Cambridge CB20QQ, UKMRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, P.O. Box 285 Hills Road, Cambridge CB20QQ, UKMetabolic Research Laboratories, Institute of Metabolic Science, Cambridge CB20QQ, UKWolfson Brain Imaging Centre, University of Cambridge, Cambridge CB20QQ, UKMRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, P.O. Box 285 Hills Road, Cambridge CB20QQ, UKMRC Lifecourse Epidemiology Unit, University of Southampton, Southampton SO166YD, UKMRC Lifecourse Epidemiology Unit, University of Southampton, Southampton SO166YD, UKMRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, P.O. Box 285 Hills Road, Cambridge CB20QQ, UKMetabolic Research Laboratories, Institute of Metabolic Science, Cambridge CB20QQ, UKMRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, P.O. Box 285 Hills Road, Cambridge CB20QQ, UKIntroduction. The mechanisms underlying the association between insulin resistance and intrahepatic lipid (IHL) accumulation are not completely understood. We sought to determine whether this association was explained by differences in fasting non-esterified fatty acid (NEFA) levels and/or NEFA suppression after oral glucose loading. Materials and Methods. We performed a cross-sectional analysis of 70 healthy participants in the Hertfordshire Physical Activity Trial (39 males, age 71.3 ± 2.4 years) who underwent oral glucose tolerance testing with glucose, insulin, and NEFA levels measured over two hours. IHL was quantified with magnetic resonance spectroscopy. Insulin sensitivity was measured with the oral glucose insulin sensitivity (OGIS) model, the leptin: adiponectin ratio (LAR), and the homeostasis model assessment (HOMA). Results. Measures of insulin sensitivity were not associated with fasting NEFA levels, but OGIS was strongly associated with NEFA suppression at 30 minutes and strongly inversely associated with IHL. Moreover, LAR was strongly inversely associated with NEFA suppression and strongly associated with IHL. This latter association (beta = 1.11 [1.01, 1.21], ) was explained by reduced NEFA suppression ( after adjustment). Conclusions. Impaired postprandial NEFA suppression, but not fasting NEFA, contributes to the strong and well-established association between whole body insulin resistance and liver fat accumulation.http://dx.doi.org/10.1155/2013/870487 |
| spellingShingle | Francis M. Finucane Stephen J. Sharp Mensud Hatunic Alison Sleigh Ema De Lucia Rolfe Avan Aihie Sayer Cyrus Cooper Simon J. Griffin David B. Savage Nicholas J. Wareham Intrahepatic Lipid Content and Insulin Resistance Are More Strongly Associated with Impaired NEFA Suppression after Oral Glucose Loading Than with Fasting NEFA Levels in Healthy Older Individuals International Journal of Endocrinology |
| title | Intrahepatic Lipid Content and Insulin Resistance Are More Strongly Associated with Impaired NEFA Suppression after Oral Glucose Loading Than with Fasting NEFA Levels in Healthy Older Individuals |
| title_full | Intrahepatic Lipid Content and Insulin Resistance Are More Strongly Associated with Impaired NEFA Suppression after Oral Glucose Loading Than with Fasting NEFA Levels in Healthy Older Individuals |
| title_fullStr | Intrahepatic Lipid Content and Insulin Resistance Are More Strongly Associated with Impaired NEFA Suppression after Oral Glucose Loading Than with Fasting NEFA Levels in Healthy Older Individuals |
| title_full_unstemmed | Intrahepatic Lipid Content and Insulin Resistance Are More Strongly Associated with Impaired NEFA Suppression after Oral Glucose Loading Than with Fasting NEFA Levels in Healthy Older Individuals |
| title_short | Intrahepatic Lipid Content and Insulin Resistance Are More Strongly Associated with Impaired NEFA Suppression after Oral Glucose Loading Than with Fasting NEFA Levels in Healthy Older Individuals |
| title_sort | intrahepatic lipid content and insulin resistance are more strongly associated with impaired nefa suppression after oral glucose loading than with fasting nefa levels in healthy older individuals |
| url | http://dx.doi.org/10.1155/2013/870487 |
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