Detrimental effects of cadmium on male infertility: A review
Infertility has become a serious health and socio-economic-psychological problem globally. The harmful role of trace metals in male infertility is recognized but still not sufficiently explained. Herein, a comprehensive review was conducted to elucidate the detrimental role of cadmium (Cd) on male i...
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Elsevier
2025-01-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651324016993 |
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| author | Nebojša Zečević Jovana Kocić Milan Perović Aleksandar Stojsavljević |
| author_facet | Nebojša Zečević Jovana Kocić Milan Perović Aleksandar Stojsavljević |
| author_sort | Nebojša Zečević |
| collection | DOAJ |
| description | Infertility has become a serious health and socio-economic-psychological problem globally. The harmful role of trace metals in male infertility is recognized but still not sufficiently explained. Herein, a comprehensive review was conducted to elucidate the detrimental role of cadmium (Cd) on male infertility, particularly on infertility with unknown (idiopathic) causes. Peer-reviewed studies from 2000 to 2024 dealing with seminal plasma and blood Cd levels of fertile and infertile men were retrieved were interrogated with regard to strict inclusion/exclusion criteria, and then were thoroughly reviewed and analyzed. Another aim of this review was to indicate the potential effects of Cd on changes in seminogram findings. A median range of seminal plasma Cd levels from 0.2 to 1.5 µg/L can be considered safe for men’s fertility. This review strongly implies that Cd levels were notably higher in seminal plasma of infertile cases than controls. The review’s data also indicate that exposure to tobacco smoke is a major source of elevated seminal and blood Cd levels in infertile men. Newer research points to the importance of Cd in lower levels from the environment on changes in seminogram findings, primarily count, motility of spermatozoa, and their morphology. Overall, this review implies that seminal plasma Cd levels could be a good indicator of semen quality. However, new, in-depth studies are needed to confirm or reject the causal relationship of Cd with male infertility. |
| format | Article |
| id | doaj-art-f11e855598344a6baf27f8fd41a708a4 |
| institution | Kabale University |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-f11e855598344a6baf27f8fd41a708a42025-02-12T05:30:01ZengElsevierEcotoxicology and Environmental Safety0147-65132025-01-01290117623Detrimental effects of cadmium on male infertility: A reviewNebojša Zečević0Jovana Kocić1Milan Perović2Aleksandar Stojsavljević3Clinic for Gynecology and Obstetrics ''Narodni front'', Kraljice Natalije 62, Belgrade, Serbia; Faculty of Medicine, University of Belgrade, Doktora Subotića 8, Belgrade, Serbia; Special Hospital Belgrade, Human Reproduction Center, Antifašističke borbe 2a, Belgrade, SerbiaClinic for Gynecology and Obstetrics ''Narodni front'', Kraljice Natalije 62, Belgrade, SerbiaClinic for Gynecology and Obstetrics ''Narodni front'', Kraljice Natalije 62, Belgrade, Serbia; Faculty of Medicine, University of Belgrade, Doktora Subotića 8, Belgrade, SerbiaInnovative Centre of the Faculty of Chemistry, University of Belgrade, Studentski trg 12-16, Belgrade, Serbia; Correspondence to: Innovation Centre, Faculty of Chemistry, University of Belgrade, Studentski trg 12-16, Belgrade, Serbia.Infertility has become a serious health and socio-economic-psychological problem globally. The harmful role of trace metals in male infertility is recognized but still not sufficiently explained. Herein, a comprehensive review was conducted to elucidate the detrimental role of cadmium (Cd) on male infertility, particularly on infertility with unknown (idiopathic) causes. Peer-reviewed studies from 2000 to 2024 dealing with seminal plasma and blood Cd levels of fertile and infertile men were retrieved were interrogated with regard to strict inclusion/exclusion criteria, and then were thoroughly reviewed and analyzed. Another aim of this review was to indicate the potential effects of Cd on changes in seminogram findings. A median range of seminal plasma Cd levels from 0.2 to 1.5 µg/L can be considered safe for men’s fertility. This review strongly implies that Cd levels were notably higher in seminal plasma of infertile cases than controls. The review’s data also indicate that exposure to tobacco smoke is a major source of elevated seminal and blood Cd levels in infertile men. Newer research points to the importance of Cd in lower levels from the environment on changes in seminogram findings, primarily count, motility of spermatozoa, and their morphology. Overall, this review implies that seminal plasma Cd levels could be a good indicator of semen quality. However, new, in-depth studies are needed to confirm or reject the causal relationship of Cd with male infertility.http://www.sciencedirect.com/science/article/pii/S0147651324016993Male infertilityCadmiumToxicitySemen qualityEnvironment |
| spellingShingle | Nebojša Zečević Jovana Kocić Milan Perović Aleksandar Stojsavljević Detrimental effects of cadmium on male infertility: A review Ecotoxicology and Environmental Safety Male infertility Cadmium Toxicity Semen quality Environment |
| title | Detrimental effects of cadmium on male infertility: A review |
| title_full | Detrimental effects of cadmium on male infertility: A review |
| title_fullStr | Detrimental effects of cadmium on male infertility: A review |
| title_full_unstemmed | Detrimental effects of cadmium on male infertility: A review |
| title_short | Detrimental effects of cadmium on male infertility: A review |
| title_sort | detrimental effects of cadmium on male infertility a review |
| topic | Male infertility Cadmium Toxicity Semen quality Environment |
| url | http://www.sciencedirect.com/science/article/pii/S0147651324016993 |
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