New options for targeting TRPV1 receptors for cancer treatment: odorous Chinese herbal medicine
Vanilloid1 (TRPV1), a subfamily of transient receptor channels, is one of the non-selective calcium channels, which is a bridge between cellular response and extracellular environmental networks, and is involved in a variety of pathophysiological processes. It is also involved in the process of canc...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1488289/full |
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| _version_ | 1823859438661926912 |
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| author | Minghui Zhang Minghui Zhang Zongao Wang Zongao Wang Shaojun Liu Shaojun Liu Yuxuan Li Yuxuan Li Yanting Gong Yanting Gong Min Liu Min Liu |
| author_facet | Minghui Zhang Minghui Zhang Zongao Wang Zongao Wang Shaojun Liu Shaojun Liu Yuxuan Li Yuxuan Li Yanting Gong Yanting Gong Min Liu Min Liu |
| author_sort | Minghui Zhang |
| collection | DOAJ |
| description | Vanilloid1 (TRPV1), a subfamily of transient receptor channels, is one of the non-selective calcium channels, which is a bridge between cellular response and extracellular environmental networks, and is involved in a variety of pathophysiological processes. It is also involved in the process of cancer occurrence and progression, and researchers are revealing its role in cancer. In this paper, we review the expression and significance of TRPV1 receptor in various cancer cell types, the role of TRPV1 in the apoptosis-proliferation balance, cancer cell invasion and metastasis, and tumor micro-environment, with emphasis on the mechanisms by which TRPV1 receptor mediates inflammatory response, immune system, and thus regulates cancer. We discussed the latest directions and current challenges of TRPV1 receptor-targeting therapy for cancer, and summarized the odorous traditional herbs that modulate TRPV1 receptors, with a view to developing anti-tumor drugs targeting TRPV1 receptors in the future. |
| format | Article |
| id | doaj-art-f10a9a19b5284d01ab1c1e500ff9460a |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-f10a9a19b5284d01ab1c1e500ff9460a2025-02-11T05:10:21ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-02-011510.3389/fonc.2025.14882891488289New options for targeting TRPV1 receptors for cancer treatment: odorous Chinese herbal medicineMinghui Zhang0Minghui Zhang1Zongao Wang2Zongao Wang3Shaojun Liu4Shaojun Liu5Yuxuan Li6Yuxuan Li7Yanting Gong8Yanting Gong9Min Liu10Min Liu11Nanjing University of Chinese Medicine, Suzhou, ChinaSuzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, ChinaNanjing University of Chinese Medicine, Suzhou, ChinaSuzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, ChinaNanjing University of Chinese Medicine, Suzhou, ChinaSuzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, ChinaNanjing University of Chinese Medicine, Suzhou, ChinaSuzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, ChinaNanjing University of Chinese Medicine, Suzhou, ChinaSuzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, ChinaNanjing University of Chinese Medicine, Suzhou, ChinaSuzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, ChinaVanilloid1 (TRPV1), a subfamily of transient receptor channels, is one of the non-selective calcium channels, which is a bridge between cellular response and extracellular environmental networks, and is involved in a variety of pathophysiological processes. It is also involved in the process of cancer occurrence and progression, and researchers are revealing its role in cancer. In this paper, we review the expression and significance of TRPV1 receptor in various cancer cell types, the role of TRPV1 in the apoptosis-proliferation balance, cancer cell invasion and metastasis, and tumor micro-environment, with emphasis on the mechanisms by which TRPV1 receptor mediates inflammatory response, immune system, and thus regulates cancer. We discussed the latest directions and current challenges of TRPV1 receptor-targeting therapy for cancer, and summarized the odorous traditional herbs that modulate TRPV1 receptors, with a view to developing anti-tumor drugs targeting TRPV1 receptors in the future.https://www.frontiersin.org/articles/10.3389/fonc.2025.1488289/fullTRPV1cancertumor micro-environmentodorous traditional herbal medicinesapoptosis |
| spellingShingle | Minghui Zhang Minghui Zhang Zongao Wang Zongao Wang Shaojun Liu Shaojun Liu Yuxuan Li Yuxuan Li Yanting Gong Yanting Gong Min Liu Min Liu New options for targeting TRPV1 receptors for cancer treatment: odorous Chinese herbal medicine Frontiers in Oncology TRPV1 cancer tumor micro-environment odorous traditional herbal medicines apoptosis |
| title | New options for targeting TRPV1 receptors for cancer treatment: odorous Chinese herbal medicine |
| title_full | New options for targeting TRPV1 receptors for cancer treatment: odorous Chinese herbal medicine |
| title_fullStr | New options for targeting TRPV1 receptors for cancer treatment: odorous Chinese herbal medicine |
| title_full_unstemmed | New options for targeting TRPV1 receptors for cancer treatment: odorous Chinese herbal medicine |
| title_short | New options for targeting TRPV1 receptors for cancer treatment: odorous Chinese herbal medicine |
| title_sort | new options for targeting trpv1 receptors for cancer treatment odorous chinese herbal medicine |
| topic | TRPV1 cancer tumor micro-environment odorous traditional herbal medicines apoptosis |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1488289/full |
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