Metformin inhibits pathological retinal neovascularization but promotes retinal fibrosis in experimental neovascular age-related macular degeneration

Metformin inhibits pathological retinal neovascularization but promotes retinal fibrosis in experimental neovascular age-related macular degeneration

PurposeThis study aims to investigate the effects and mechanism of action of metformin on retinal neovascularization and fibrosis in a mouse model of neovascular age-related macular degeneration (nAMD).MethodsVery low-density lipoprotein receptor knockout (Vldlr−/−) mice, a mouse model of nAMD, were...

Full description

Saved in:

Bibliographic Details
Main Authors:	Xin Wang, Xu Liang, Shiya Huang, Mingyan Wei, Yuan Xu, Xiaodong Chen, Yanliang Miao, Rongrong Zong, Xiang Lin, Shiying Li, Zuguo Liu, Qian Chen
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-03-01
Series:	Frontiers in Pharmacology
Subjects:	metformin retinal neovascularization age-related macular degeneration neovascular AMD very low-density lipoprotein receptor retinal fibrosis
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1547492/full
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Clinical and imaging characteristics of retinal neovascularization secondary to Behçet's uveitis
by: CHEN Xuelin, et al.
Published: (2025-02-01)

Inhibition of retinal neovascularization by Dendrobium polysaccharides: a review
by: Dan Liu, et al.
Published: (2025-06-01)

Posterior Vitreous Detachment and Risk of Neovascular Glaucoma in Eyes with Prior Retinal Vascular Occlusions
by: Laura D. Palmer, et al.
Published: (2024-09-01)

A pilot study : retinal sensitivity change in neovascular age-related macular degeneration patients with better baseline visual acuity
by: Jae Hyup Lee, et al.
Published: (2024-11-01)

OCT predictors of retinal atrophy in neovascular age-related macular degeneration treated with aflibercept
by: Oscar M. Gagliardi, et al.
Published: (2025-04-01)

Multimodal Imaging of Quiescent Choroidal Neovascularization: Status of Retinal Pigment Epithelium
by: A. N. Kulikov, et al.
Published: (2023-04-01)

Thymoquinone as a Natural Anti-Angiogenic Agent: Experimental Pharmacology insights into Schematic and Meta-Analysis of Ocular Neovascularization and Retinal Pathology
by: Soobia Pathan, et al.
Published: (2025-07-01)

Initial experience with brolucizumab for neovascular age-related macular degeneration (nAMD) in India – Multicentric, real-world study
by: Deependra Vikram Singh, et al.
Published: (2024-12-01)

Retinal sensitivity above macular neovascularization under anti-VEGF therapy in exudative neovascular age-related macular degeneration
by: Laurenz Pauleikhoff, et al.
Published: (2025-03-01)

Analysis of Clinical Study Results Obtained in Patients with Neovascular Age-Related Macular Degeneration in 2005–2020. Review
by: N. A. Gavrilova, et al.
Published: (2022-04-01)

Efficacy of modified diode transscleral cyclophotocoagulation in patients with painful neovascular glaucoma secondary to retinal vein occlusion
by: O.V. Guzun, et al.
Published: (2025-06-01)

Choroidal neovascularization activity and structure by optical coherence tomography angiography in age related macular degeneration
by: M. A. Kovalevskaya, et al.
Published: (2021-12-01)

Neovascular Glaucoma as the First Symptom of Bilateral Occlusive Retinal Vasculitis in a 4-Year-Old Girl: A Case Report
by: Klaudia Rakusiewicz-Krasnodębska, et al.
Published: (2025-01-01)

Retinocochleocerebral Vasculopathy Presented as Bilateral Neovascular Glaucoma
by: Mehrdad Motamed Shariati, et al.
Published: (2025-01-01)

Outcomes of Anti-VEGF Therapy in Eyes with Diabetic Macular Edema, Vein Occlusion-Related Macular Edema, and Neovascular Age-Related Macular Degeneration: A Systematic Review
by: Aldokhail LS, et al.
Published: (2024-12-01)

Retinal vascular proliferation with fibrotic regression in von Hippel–Lindau disease
by: Jing-Yi Chen, et al.
Published: (2025-01-01)

Application of Artificial Intelligence Models to Predict the Onset or Recurrence of Neovascular Age-Related Macular Degeneration
by: Francesco Saverio Sorrentino, et al.
Published: (2024-10-01)

Central Retinal Vein Occlusion (CRVO) complicating post-cataract surgery: a case report and multifactorial analysis
by: Li Xiaodong, et al.
Published: (2025-07-01)

Clinical Profile and Treatment Outcomes of Patients with Neovascular Glaucoma in a Tertiary Hospital in the Philippines
by: Angela Therese Y. Uy, MD, et al.
Published: (2021-12-01)

RGD-Functionalized Ginsenoside Rg3 Liposomes for Alleviating Oxidative Stress and Choroidal Neovascularization in Age-Related Macular Degeneration
by: Zhou J, et al.
Published: (2025-06-01)

Real-World Outcomes of Brolucizumab Treatment in Japanese Patients with Neovascular Age-Related Macular Degeneration: A 12-Month, Multicenter Study
by: Masayuki Ohnaka, et al.
Published: (2025-05-01)

Lycium barbarum polysaccharide inhibits retinal neovascularization and inflammation in vitro and in vivo
by: Bin Wu, et al.
Published: (2025-02-01)

Postpartum Exudation of Idiopathic Quiescent Macular Neovascularization: A Narrative Review with a Related Case Report
by: Livio Vitiello, et al.
Published: (2024-12-01)

Receptor-Interacting Protein Kinase-3 Expression Impacts Ocular Vascular Development and Pathological Neovascularization
by: Yong-Seok Song, et al.
Published: (2024-12-01)

Rac1 overexpression promotes Treg-derived cytokines to mediate choroidal neovascularization in wet age-related macular degeneration
by: Juanjuan Li, et al.
Published: (2025-03-01)

Clinical Evaluation of the Effectiveness of Neovascular Age-related Macular Degeneration Combined Treatment
by: L. A. Golota, et al.
Published: (2025-03-01)

12-month outcomes of ziv-aflibercept for neovascular age-related macular degeneration in eyes previously treated with aflibercept
by: Wajiha J Kheir, et al.
Published: (2025-01-01)

Cilioretinal arteries and collateral vessels after occlusion of central retinal artery
by: Petrović Nenad, et al.
Published: (2018-01-01)

The natural preferred retinal locus in patients with macular disease
by: Shengnan Li, et al.
Published: (2025-07-01)

Real-World 5-Year Outcomes of Age-Related Macular Degeneration with Bevacizumab as First-Line Anti-VEGF
by: H. Mhmud, et al.
Published: (2025-06-01)

Photodynamic therapy for neovascular age-related macular degeneration
by: Richard P.L. Wormald, MA, MB, BCh, MSc, FRCS, FRCOphth, et al.
Published: (2005-06-01)

OCTNet: A Modified Multi-Scale Attention Feature Fusion Network with InceptionV3 for Retinal OCT Image Classification
by: Irshad Khalil, et al.
Published: (2024-09-01)

Efficacy and Safety of Aflibercept Biosimilars Relative to Reference Aflibercept Therapy for Neovascular Age-Related Macular Degeneration: A Systematic Review and Meta-Analysis
by: Aljuhani HS, et al.
Published: (2025-06-01)

The effect of a specific vitamin supplement containing L-methylfolate (Ocufolin forte) in patients with neovascular age-related macular degeneration
by: Tatjana Josifova, et al.
Published: (2025-05-01)

Prognostic biomarkers in treatment-naïve central retinal vein occlusion with macular edema
by: Yu Song, et al.
Published: (2025-07-01)

Effect of combined therapy based on transscleral peripheral retinal cryotherapy in the treatment of open-angle neovascular glaucoma: a retrospective study
by: Lixiong Gao, et al.
Published: (2025-07-01)

Interferon‐beta signaling in retinal mononuclear phagocytes attenuates pathological neovascularization
by: Anika Lückoff, et al.
Published: (2016-05-01)

Clinical Profile and Management of Neovascular Glaucoma in North India
by: Ketaki Rajurkar, et al.
Published: (2022-10-01)

Use of Bevacizumab in the Treatment of Corneal Neovascularization
by: Tuba Çelik, et al.
Published: (2015-01-01)

Early detection of choroidal neovascularization in age related macular degeneration
by: Tural Galbinur
Published: (2014-07-01)