THE EFFECTIVENESS OF ZINC AND RISEDRONATE ON BONE TURNOVER IN RAT MODEL OF OSTEOPOROSIS ASSESSED WITH THE EXPRESSION OF β-CROSSLAPS

Background: Osteoporosis prevalence in Indonesia is high. Risedronate commonly used for treating the osteoporosis. Unfortunately, long term therapy can cause hazardous adverse effect to the patient. Previous research in rat model osteoporosis, Zinc have a potential effect to prevent and rebuild bone...

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Main Authors: Adam Fajar, Mohammad Rizal Chaidir, Dicky Mulyadi, Ahmad Ramdan, Yoyos Dias Ismiarto
Format: Article
Language:English
Published: Universitas Airlangga 2019-12-01
Series:Journal Orthopaedi and Traumatology Surabaya
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Online Access:https://e-journal.unair.ac.id/JOINTS/article/view/16567
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author Adam Fajar
Mohammad Rizal Chaidir
Dicky Mulyadi
Ahmad Ramdan
Yoyos Dias Ismiarto
author_facet Adam Fajar
Mohammad Rizal Chaidir
Dicky Mulyadi
Ahmad Ramdan
Yoyos Dias Ismiarto
author_sort Adam Fajar
collection DOAJ
description Background: Osteoporosis prevalence in Indonesia is high. Risedronate commonly used for treating the osteoporosis. Unfortunately, long term therapy can cause hazardous adverse effect to the patient. Previous research in rat model osteoporosis, Zinc have a potential effect to prevent and rebuild bone structure with osteoblast stimulation in bone formation and osteoclast activity inhibition in bone resorption by increasing Osteoprotegerin production, that inhibit bond between RANKL and RANK. Purpose: To determine the effectiveness of Zink and Risedronate on bone turnover in osteoporotic model rats assessed the β-CrossLaps expression. Methods: This research is conducted as experimental comparative method used 25 female Galur Wistar rat that divided into Non-ovariectomy and Ovariectomy group to induce osteoporosis. The treatment is divided into Zinc-Risedronate, and Zinc, or Risedronate only. One Way Anova and Independent T-test was used to analyzed the significant difference between groups. Result: One Way Anova statistic test forβ-CrossLaps expression value in the 3rd Taken blood sample showed that p is less than 0.05 (p<0.05), which indicated that are significant difference in the mean between variable at 3rd Taken blood sample in all group. Meanwhile, Independent T-test was used to compare β-CrossLaps expression in 3rd taken blood sample between Ovari and Ovari+Zinc, Ovari and Ovari+Zinc+Rise showed p is less than 0.05 (p<0.05), which indicated that there are significant difference in the mean between variable 2 groups. Conclusion: Zinc-Risedronate administration will decrease bone turnover and β-CrossLaps expression more than Zinc or Risedronate only in rat model osteoporosis.
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spelling doaj-art-f0fcb69482434c4fb1c0f047715b40222025-02-12T07:29:22ZengUniversitas AirlanggaJournal Orthopaedi and Traumatology Surabaya2722-712X2460-87422019-12-017211412410.20473/joints.v7i2.2018.114-12413517THE EFFECTIVENESS OF ZINC AND RISEDRONATE ON BONE TURNOVER IN RAT MODEL OF OSTEOPOROSIS ASSESSED WITH THE EXPRESSION OF β-CROSSLAPSAdam Fajar0Mohammad Rizal Chaidir1Dicky Mulyadi2Ahmad Ramdan3Yoyos Dias Ismiarto4Resident of Orthopaedic and Traumatology Department, Faculty of Medicine Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital, BandungStaff of Orthopaedics and Traumatology Department, Faculty of Medicine Universitas Padjadjaran/Dr. Hasan Sadikin Hospital, BandungStaff of Orthopaedics and Traumatology Department, Faculty of Medicine Universitas Padjadjaran/Dr. Hasan Sadikin Hospital, BandungStaff of Orthopaedics and Traumatology Department, Faculty of Medicine Universitas Padjadjaran/Dr. Hasan Sadikin Hospital, BandungHead of Study Program of Orthopaedics and Traumatology Department, Faculty of Medicine Universitas Padjadjaran/Dr. Hasan Sadikin Hospital, BandungBackground: Osteoporosis prevalence in Indonesia is high. Risedronate commonly used for treating the osteoporosis. Unfortunately, long term therapy can cause hazardous adverse effect to the patient. Previous research in rat model osteoporosis, Zinc have a potential effect to prevent and rebuild bone structure with osteoblast stimulation in bone formation and osteoclast activity inhibition in bone resorption by increasing Osteoprotegerin production, that inhibit bond between RANKL and RANK. Purpose: To determine the effectiveness of Zink and Risedronate on bone turnover in osteoporotic model rats assessed the β-CrossLaps expression. Methods: This research is conducted as experimental comparative method used 25 female Galur Wistar rat that divided into Non-ovariectomy and Ovariectomy group to induce osteoporosis. The treatment is divided into Zinc-Risedronate, and Zinc, or Risedronate only. One Way Anova and Independent T-test was used to analyzed the significant difference between groups. Result: One Way Anova statistic test forβ-CrossLaps expression value in the 3rd Taken blood sample showed that p is less than 0.05 (p<0.05), which indicated that are significant difference in the mean between variable at 3rd Taken blood sample in all group. Meanwhile, Independent T-test was used to compare β-CrossLaps expression in 3rd taken blood sample between Ovari and Ovari+Zinc, Ovari and Ovari+Zinc+Rise showed p is less than 0.05 (p<0.05), which indicated that there are significant difference in the mean between variable 2 groups. Conclusion: Zinc-Risedronate administration will decrease bone turnover and β-CrossLaps expression more than Zinc or Risedronate only in rat model osteoporosis.https://e-journal.unair.ac.id/JOINTS/article/view/16567osteoporosisrisedronatezinkβ-crosslaps
spellingShingle Adam Fajar
Mohammad Rizal Chaidir
Dicky Mulyadi
Ahmad Ramdan
Yoyos Dias Ismiarto
THE EFFECTIVENESS OF ZINC AND RISEDRONATE ON BONE TURNOVER IN RAT MODEL OF OSTEOPOROSIS ASSESSED WITH THE EXPRESSION OF β-CROSSLAPS
Journal Orthopaedi and Traumatology Surabaya
osteoporosis
risedronate
zink
β-crosslaps
title THE EFFECTIVENESS OF ZINC AND RISEDRONATE ON BONE TURNOVER IN RAT MODEL OF OSTEOPOROSIS ASSESSED WITH THE EXPRESSION OF β-CROSSLAPS
title_full THE EFFECTIVENESS OF ZINC AND RISEDRONATE ON BONE TURNOVER IN RAT MODEL OF OSTEOPOROSIS ASSESSED WITH THE EXPRESSION OF β-CROSSLAPS
title_fullStr THE EFFECTIVENESS OF ZINC AND RISEDRONATE ON BONE TURNOVER IN RAT MODEL OF OSTEOPOROSIS ASSESSED WITH THE EXPRESSION OF β-CROSSLAPS
title_full_unstemmed THE EFFECTIVENESS OF ZINC AND RISEDRONATE ON BONE TURNOVER IN RAT MODEL OF OSTEOPOROSIS ASSESSED WITH THE EXPRESSION OF β-CROSSLAPS
title_short THE EFFECTIVENESS OF ZINC AND RISEDRONATE ON BONE TURNOVER IN RAT MODEL OF OSTEOPOROSIS ASSESSED WITH THE EXPRESSION OF β-CROSSLAPS
title_sort effectiveness of zinc and risedronate on bone turnover in rat model of osteoporosis assessed with the expression of β crosslaps
topic osteoporosis
risedronate
zink
β-crosslaps
url https://e-journal.unair.ac.id/JOINTS/article/view/16567
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