Triterpenoids from The Bark of Garcinia porecta and their Cytotoxic Activity against MCF7 Breast Cancer Lines
The Garcinia genus is a well known tropical plant in the Indo-Malesiana region and mainly distributed in tropical countries including Indonesia, Thailand, and Malaysia. Previous phytochemical studies on Garcinia species have led to the identification and isolation of mainly prenylated xanthones. Thi...
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| Format: | Article |
| Language: | English |
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Universitas Sebelas Maret
2019-03-01
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| Series: | Alchemy |
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| Online Access: | https://jurnal.uns.ac.id/alchemy/article/view/20262 |
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| author | Darwati Darwati Alya Tsamrotul Tati Herlina Tri Mayanti Nurlelasari Nurlelasari Kansy Haikal Unang Supratman |
| author_facet | Darwati Darwati Alya Tsamrotul Tati Herlina Tri Mayanti Nurlelasari Nurlelasari Kansy Haikal Unang Supratman |
| author_sort | Darwati Darwati |
| collection | DOAJ |
| description | The Garcinia genus is a well known tropical plant in the Indo-Malesiana region and mainly distributed in tropical countries including Indonesia, Thailand, and Malaysia. Previous phytochemical studies on Garcinia species have led to the identification and isolation of mainly prenylated xanthones. This research describes the isolation and structure elucidation of isolated triterpenoids compounds from the bark of Garcinia porecta. Dried powder bark of G. porecta was extracted with methanol and then partitioned with n-hexane, ethyl acetate, and n-butanol. The n-hexane extract then was separated and purified with chromatography techniques to obtain isolated compounds 1 and 2. The chemical structure of isolated compounds was elucidated by spectroscopic methods including one and two-dimensional NMR as well as high-resolution mass spectrometric analysis and identified as lanosterol (1) dan arabidiol (2), respectively. These triterpenoids were isolated from this plant for the first time. Compound 1 and 2 showed weak cytotoxic activity against MCF-7 breast cancer cells with IC50 values of 60.09 dan 46.17 µM, respectively. |
| format | Article |
| id | doaj-art-f0f2e026d1f7468fbbdae5a25b88e9e2 |
| institution | Kabale University |
| issn | 1412-4092 2443-4183 |
| language | English |
| publishDate | 2019-03-01 |
| publisher | Universitas Sebelas Maret |
| record_format | Article |
| series | Alchemy |
| spelling | doaj-art-f0f2e026d1f7468fbbdae5a25b88e9e22025-01-02T06:52:27ZengUniversitas Sebelas MaretAlchemy1412-40922443-41832019-03-011511910.20961/alchemy.15.1.20262.1-919022Triterpenoids from The Bark of Garcinia porecta and their Cytotoxic Activity against MCF7 Breast Cancer LinesDarwati Darwati0Alya Tsamrotul1Tati Herlina2Tri Mayanti3Nurlelasari Nurlelasari4Kansy Haikal5Unang Supratman6Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Sumedang, IndonesiaDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Sumedang, IndonesiaDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Sumedang, IndonesiaDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Sumedang, IndonesiaDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Sumedang, IndonesiaCentral Laboratory, Universitas Padjadjaran, Jatinangor 45363, Sumedang, IndonesiaDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Sumedang, Indonesia Central Laboratory, Universitas Padjadjaran, Jatinangor 45363, Sumedang, IndonesiaThe Garcinia genus is a well known tropical plant in the Indo-Malesiana region and mainly distributed in tropical countries including Indonesia, Thailand, and Malaysia. Previous phytochemical studies on Garcinia species have led to the identification and isolation of mainly prenylated xanthones. This research describes the isolation and structure elucidation of isolated triterpenoids compounds from the bark of Garcinia porecta. Dried powder bark of G. porecta was extracted with methanol and then partitioned with n-hexane, ethyl acetate, and n-butanol. The n-hexane extract then was separated and purified with chromatography techniques to obtain isolated compounds 1 and 2. The chemical structure of isolated compounds was elucidated by spectroscopic methods including one and two-dimensional NMR as well as high-resolution mass spectrometric analysis and identified as lanosterol (1) dan arabidiol (2), respectively. These triterpenoids were isolated from this plant for the first time. Compound 1 and 2 showed weak cytotoxic activity against MCF-7 breast cancer cells with IC50 values of 60.09 dan 46.17 µM, respectively.https://jurnal.uns.ac.id/alchemy/article/view/20262arabidiolgarcinia porectalanosterolmcf7 breast cancer cellstriterpenoid |
| spellingShingle | Darwati Darwati Alya Tsamrotul Tati Herlina Tri Mayanti Nurlelasari Nurlelasari Kansy Haikal Unang Supratman Triterpenoids from The Bark of Garcinia porecta and their Cytotoxic Activity against MCF7 Breast Cancer Lines Alchemy arabidiol garcinia porecta lanosterol mcf7 breast cancer cells triterpenoid |
| title | Triterpenoids from The Bark of Garcinia porecta and their Cytotoxic Activity against MCF7 Breast Cancer Lines |
| title_full | Triterpenoids from The Bark of Garcinia porecta and their Cytotoxic Activity against MCF7 Breast Cancer Lines |
| title_fullStr | Triterpenoids from The Bark of Garcinia porecta and their Cytotoxic Activity against MCF7 Breast Cancer Lines |
| title_full_unstemmed | Triterpenoids from The Bark of Garcinia porecta and their Cytotoxic Activity against MCF7 Breast Cancer Lines |
| title_short | Triterpenoids from The Bark of Garcinia porecta and their Cytotoxic Activity against MCF7 Breast Cancer Lines |
| title_sort | triterpenoids from the bark of garcinia porecta and their cytotoxic activity against mcf7 breast cancer lines |
| topic | arabidiol garcinia porecta lanosterol mcf7 breast cancer cells triterpenoid |
| url | https://jurnal.uns.ac.id/alchemy/article/view/20262 |
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