A Case of Systemic Lupus Erythematosus/Antineutrophil Cytoplasmic Antibody-Associated Vasculitis Overlap Syndrome with Dissociated Pathological and Immunological Findings
Systemic lupus erythematosus/antineutrophil cytoplasmic antibody-associated vasculitis overlap syndrome (SLE/AAV OS) describes a pathological condition that presents with overlapping features of two diseases. There have been few reports of SLE/AAV OS and none from Japan. We present the case of a 59-...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Case Reports in Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2020/5698708 |
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| author | Kazuhiko Kato Tetsuya Kawamura Risa Terashima Yukiko Tsuchiya Yasuhito Takahashi Kenji Kasai Takashi Yokoo |
| author_facet | Kazuhiko Kato Tetsuya Kawamura Risa Terashima Yukiko Tsuchiya Yasuhito Takahashi Kenji Kasai Takashi Yokoo |
| author_sort | Kazuhiko Kato |
| collection | DOAJ |
| description | Systemic lupus erythematosus/antineutrophil cytoplasmic antibody-associated vasculitis overlap syndrome (SLE/AAV OS) describes a pathological condition that presents with overlapping features of two diseases. There have been few reports of SLE/AAV OS and none from Japan. We present the case of a 59-year-old woman admitted with chief complaints of fever and decreased renal function. SLE was suspected due to the identification of four items from the diagnostic criteria of the American College of Rheumatology, including positivity for anti-ds-DNA and antinuclear antibodies. However, pathological findings from the kidney biopsy suggested pauci-immune crescentic glomerulonephritis. She was also diagnosed with AAV according to the Chapel Hill Consensus Conference (CHCC) 2012 definitions and the classification algorithm of AAV. SLE/AAV OS was suspected, we started immunosuppressant therapy, and subsequently her renal function improved. In previous reports, initial immunological and pathological findings generally concur. In cases where clinical and pathological features appear to conflict, as in the present case, a treatment strategy decision should be based on pathological and immunological findings to improve the prognosis of OS. |
| format | Article |
| id | doaj-art-f0e06d843be74b82a68c26f9df16e6fa |
| institution | Kabale University |
| issn | 2090-6641 2090-665X |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Nephrology |
| spelling | doaj-art-f0e06d843be74b82a68c26f9df16e6fa2025-02-03T06:43:39ZengWileyCase Reports in Nephrology2090-66412090-665X2020-01-01202010.1155/2020/56987085698708A Case of Systemic Lupus Erythematosus/Antineutrophil Cytoplasmic Antibody-Associated Vasculitis Overlap Syndrome with Dissociated Pathological and Immunological FindingsKazuhiko Kato0Tetsuya Kawamura1Risa Terashima2Yukiko Tsuchiya3Yasuhito Takahashi4Kenji Kasai5Takashi Yokoo6Department of Internal Medicine, Fuji City General Hospital, Takashima-cho 50, Fuji-shi, Shizuoka, JapanDivision of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, JapanDepartment of Internal Medicine, Fuji City General Hospital, Takashima-cho 50, Fuji-shi, Shizuoka, JapanDepartment of Internal Medicine, Fuji City General Hospital, Takashima-cho 50, Fuji-shi, Shizuoka, JapanDepartment of Internal Medicine, Fuji City General Hospital, Takashima-cho 50, Fuji-shi, Shizuoka, JapanDepartment of Internal Medicine, Fuji City General Hospital, Takashima-cho 50, Fuji-shi, Shizuoka, JapanDivision of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, JapanSystemic lupus erythematosus/antineutrophil cytoplasmic antibody-associated vasculitis overlap syndrome (SLE/AAV OS) describes a pathological condition that presents with overlapping features of two diseases. There have been few reports of SLE/AAV OS and none from Japan. We present the case of a 59-year-old woman admitted with chief complaints of fever and decreased renal function. SLE was suspected due to the identification of four items from the diagnostic criteria of the American College of Rheumatology, including positivity for anti-ds-DNA and antinuclear antibodies. However, pathological findings from the kidney biopsy suggested pauci-immune crescentic glomerulonephritis. She was also diagnosed with AAV according to the Chapel Hill Consensus Conference (CHCC) 2012 definitions and the classification algorithm of AAV. SLE/AAV OS was suspected, we started immunosuppressant therapy, and subsequently her renal function improved. In previous reports, initial immunological and pathological findings generally concur. In cases where clinical and pathological features appear to conflict, as in the present case, a treatment strategy decision should be based on pathological and immunological findings to improve the prognosis of OS.http://dx.doi.org/10.1155/2020/5698708 |
| spellingShingle | Kazuhiko Kato Tetsuya Kawamura Risa Terashima Yukiko Tsuchiya Yasuhito Takahashi Kenji Kasai Takashi Yokoo A Case of Systemic Lupus Erythematosus/Antineutrophil Cytoplasmic Antibody-Associated Vasculitis Overlap Syndrome with Dissociated Pathological and Immunological Findings Case Reports in Nephrology |
| title | A Case of Systemic Lupus Erythematosus/Antineutrophil Cytoplasmic Antibody-Associated Vasculitis Overlap Syndrome with Dissociated Pathological and Immunological Findings |
| title_full | A Case of Systemic Lupus Erythematosus/Antineutrophil Cytoplasmic Antibody-Associated Vasculitis Overlap Syndrome with Dissociated Pathological and Immunological Findings |
| title_fullStr | A Case of Systemic Lupus Erythematosus/Antineutrophil Cytoplasmic Antibody-Associated Vasculitis Overlap Syndrome with Dissociated Pathological and Immunological Findings |
| title_full_unstemmed | A Case of Systemic Lupus Erythematosus/Antineutrophil Cytoplasmic Antibody-Associated Vasculitis Overlap Syndrome with Dissociated Pathological and Immunological Findings |
| title_short | A Case of Systemic Lupus Erythematosus/Antineutrophil Cytoplasmic Antibody-Associated Vasculitis Overlap Syndrome with Dissociated Pathological and Immunological Findings |
| title_sort | case of systemic lupus erythematosus antineutrophil cytoplasmic antibody associated vasculitis overlap syndrome with dissociated pathological and immunological findings |
| url | http://dx.doi.org/10.1155/2020/5698708 |
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