An Injectable PEG/Diacerein‐Based Anti‐Inflammatory Hydrogel for Promoting Cartilage Regeneration: An In Vivo Study
Abstract Cartilage defects are common joint disorders that, if left untreated, may progress to severe degenerative joint conditions. Inflammatory response plays a critical role in the pathogenesis of cartilage damage. Hydrogels incorporating diacerein, an anti‐inflammatory drug used in clinical sett...
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2025-05-01
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| Series: | Macromolecular Materials and Engineering |
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| Online Access: | https://doi.org/10.1002/mame.202400382 |
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| author | Jing Mi Linghui Meng Yutian Wang Huanyu Zhang Jing Jin Jianhao Huang Jingwei Lu Pu Ying Lan Li |
| author_facet | Jing Mi Linghui Meng Yutian Wang Huanyu Zhang Jing Jin Jianhao Huang Jingwei Lu Pu Ying Lan Li |
| author_sort | Jing Mi |
| collection | DOAJ |
| description | Abstract Cartilage defects are common joint disorders that, if left untreated, may progress to severe degenerative joint conditions. Inflammatory response plays a critical role in the pathogenesis of cartilage damage. Hydrogels incorporating diacerein, an anti‐inflammatory drug used in clinical settings, can mitigate inflammation that impairs cartilage repair. It is hypothesized that the direct injection of a hydrogel scaffold combining diacerein and polydopamine into cartilage defect sites can enhance localized treatment, reduce surgical risks, and expedite recovery. Therefore, in this study, a hydrogel infused with diacerein is developed to investigate its efficacy for cartilage restoration. By crosslinking poly(ethylene glycol) diacrylate, four‐arm polyethylene glycol‐functionalized diacerein, hyaluronic acid, and polydopamine, an injectable hydrogel with superior properties is achieved. In vitro evaluations confirm the mechanical strength and biocompatibility of the hydrogel, and in vivo studies demonstrate its effectiveness in cartilage repair and anti‐inflammatory activity in a rat model. These findings indicate that hydrogels are promising materials for addressing cartilage defects and advancing tissue engineering and biological implantation strategies. |
| format | Article |
| id | doaj-art-f0df037aab4b4cddaa4e0d01bb5ee2c5 |
| institution | Kabale University |
| issn | 1438-7492 1439-2054 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Macromolecular Materials and Engineering |
| spelling | doaj-art-f0df037aab4b4cddaa4e0d01bb5ee2c52025-08-20T03:49:46ZengWiley-VCHMacromolecular Materials and Engineering1438-74921439-20542025-05-013105n/an/a10.1002/mame.202400382An Injectable PEG/Diacerein‐Based Anti‐Inflammatory Hydrogel for Promoting Cartilage Regeneration: An In Vivo StudyJing Mi0Linghui Meng1Yutian Wang2Huanyu Zhang3Jing Jin4Jianhao Huang5Jingwei Lu6Pu Ying7Lan Li8Division of Sports Medicine and Adult Reconstructive Surgery Department of Orthopedic Surgery Drum Tower Hospital affiliated to Medical School of Nanjing University Nanjing 210008 ChinaDepartment of Tissue Engineering Center of 3D Printing & Organ Manufacturing School of Fundamental Sciences China Medical University Shenyang 110122 ChinaDivision of Sports Medicine and Adult Reconstructive Surgery Department of Orthopedic Surgery Drum Tower Hospital affiliated to Medical School of Nanjing University Nanjing 210008 ChinaHangzhou Lancet Robotics Company Ltd Hangzhou 311199 ChinaDivision of Sports Medicine and Adult Reconstructive Surgery Department of Orthopedic Surgery Drum Tower Hospital affiliated to Medical School of Nanjing University Nanjing 210008 ChinaDivision of Sports Medicine and Adult Reconstructive Surgery Department of Orthopedic Surgery Drum Tower Hospital affiliated to Medical School of Nanjing University Nanjing 210008 ChinaDepartment of Sports Medicine Tongji Hospital School of Medicine Tongji University Shanghai 200065 ChinaDepartment of Orthopaedics Changshu Hospital Affiliated to Nanjing University of Chinese Medicine Suzhou 215500 ChinaDivision of Sports Medicine and Adult Reconstructive Surgery Department of Orthopedic Surgery Drum Tower Hospital affiliated to Medical School of Nanjing University Nanjing 210008 ChinaAbstract Cartilage defects are common joint disorders that, if left untreated, may progress to severe degenerative joint conditions. Inflammatory response plays a critical role in the pathogenesis of cartilage damage. Hydrogels incorporating diacerein, an anti‐inflammatory drug used in clinical settings, can mitigate inflammation that impairs cartilage repair. It is hypothesized that the direct injection of a hydrogel scaffold combining diacerein and polydopamine into cartilage defect sites can enhance localized treatment, reduce surgical risks, and expedite recovery. Therefore, in this study, a hydrogel infused with diacerein is developed to investigate its efficacy for cartilage restoration. By crosslinking poly(ethylene glycol) diacrylate, four‐arm polyethylene glycol‐functionalized diacerein, hyaluronic acid, and polydopamine, an injectable hydrogel with superior properties is achieved. In vitro evaluations confirm the mechanical strength and biocompatibility of the hydrogel, and in vivo studies demonstrate its effectiveness in cartilage repair and anti‐inflammatory activity in a rat model. These findings indicate that hydrogels are promising materials for addressing cartilage defects and advancing tissue engineering and biological implantation strategies.https://doi.org/10.1002/mame.202400382anti‐inflammationcartilage regenerationdiacereinhydrogelinjectable |
| spellingShingle | Jing Mi Linghui Meng Yutian Wang Huanyu Zhang Jing Jin Jianhao Huang Jingwei Lu Pu Ying Lan Li An Injectable PEG/Diacerein‐Based Anti‐Inflammatory Hydrogel for Promoting Cartilage Regeneration: An In Vivo Study Macromolecular Materials and Engineering anti‐inflammation cartilage regeneration diacerein hydrogel injectable |
| title | An Injectable PEG/Diacerein‐Based Anti‐Inflammatory Hydrogel for Promoting Cartilage Regeneration: An In Vivo Study |
| title_full | An Injectable PEG/Diacerein‐Based Anti‐Inflammatory Hydrogel for Promoting Cartilage Regeneration: An In Vivo Study |
| title_fullStr | An Injectable PEG/Diacerein‐Based Anti‐Inflammatory Hydrogel for Promoting Cartilage Regeneration: An In Vivo Study |
| title_full_unstemmed | An Injectable PEG/Diacerein‐Based Anti‐Inflammatory Hydrogel for Promoting Cartilage Regeneration: An In Vivo Study |
| title_short | An Injectable PEG/Diacerein‐Based Anti‐Inflammatory Hydrogel for Promoting Cartilage Regeneration: An In Vivo Study |
| title_sort | injectable peg diacerein based anti inflammatory hydrogel for promoting cartilage regeneration an in vivo study |
| topic | anti‐inflammation cartilage regeneration diacerein hydrogel injectable |
| url | https://doi.org/10.1002/mame.202400382 |
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