Understanding amblyopia from the perspective of neurovascular units: changes in the retina and brain
As a developmental vision disorder, amblyopia has traditionally been studied with a focus on neurons. However, the neurovascular unit (NVU), a dynamic functional complex of neurons, blood vessels, and glial cells, has recently been implicated in amblyopia. This review systematically discusses the pa...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2025.1590009/full |
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| author | Lin Zhang Yaqi Zhao Xiaolu Shi Fan Wu Yi Shen |
| author_facet | Lin Zhang Yaqi Zhao Xiaolu Shi Fan Wu Yi Shen |
| author_sort | Lin Zhang |
| collection | DOAJ |
| description | As a developmental vision disorder, amblyopia has traditionally been studied with a focus on neurons. However, the neurovascular unit (NVU), a dynamic functional complex of neurons, blood vessels, and glial cells, has recently been implicated in amblyopia. This review systematically discusses the pathological changes and functional interactions of the NVU in retina and brain in amblyopia patients and experimental models, providing a new perspective for clinical intervention. |
| format | Article |
| id | doaj-art-f0d8daa5ee17450a99cdccd9d72eb7e2 |
| institution | Kabale University |
| issn | 2296-634X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj-art-f0d8daa5ee17450a99cdccd9d72eb7e22025-08-20T03:30:32ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2025-06-011310.3389/fcell.2025.15900091590009Understanding amblyopia from the perspective of neurovascular units: changes in the retina and brainLin Zhang0Yaqi Zhao1Xiaolu Shi2Fan Wu3Yi Shen4Special Education College, Beijing Union University, Beijing, ChinaSpecial Education College, Beijing Union University, Beijing, ChinaExperimental Research Center, China Academy of Chinese Medical Sciences, Beijing, ChinaSpecial Education College, Beijing Union University, Beijing, ChinaSpecial Education College, Beijing Union University, Beijing, ChinaAs a developmental vision disorder, amblyopia has traditionally been studied with a focus on neurons. However, the neurovascular unit (NVU), a dynamic functional complex of neurons, blood vessels, and glial cells, has recently been implicated in amblyopia. This review systematically discusses the pathological changes and functional interactions of the NVU in retina and brain in amblyopia patients and experimental models, providing a new perspective for clinical intervention.https://www.frontiersin.org/articles/10.3389/fcell.2025.1590009/fullamblyopianeurovascular unitretinabrainneural plasticity |
| spellingShingle | Lin Zhang Yaqi Zhao Xiaolu Shi Fan Wu Yi Shen Understanding amblyopia from the perspective of neurovascular units: changes in the retina and brain Frontiers in Cell and Developmental Biology amblyopia neurovascular unit retina brain neural plasticity |
| title | Understanding amblyopia from the perspective of neurovascular units: changes in the retina and brain |
| title_full | Understanding amblyopia from the perspective of neurovascular units: changes in the retina and brain |
| title_fullStr | Understanding amblyopia from the perspective of neurovascular units: changes in the retina and brain |
| title_full_unstemmed | Understanding amblyopia from the perspective of neurovascular units: changes in the retina and brain |
| title_short | Understanding amblyopia from the perspective of neurovascular units: changes in the retina and brain |
| title_sort | understanding amblyopia from the perspective of neurovascular units changes in the retina and brain |
| topic | amblyopia neurovascular unit retina brain neural plasticity |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2025.1590009/full |
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