Primary Cutaneous CD30+ Anaplastic Large T Cell Lymphoma in a Patient Treated with Cyclosporine for Actinic Reticuloid
Actinic reticuloid (AR)—a subtype of chronic actinic dermatitis—clinically and histopathologically shows lymphoma-like features. We report a male patient initially diagnosed with erythrodermic cutaneous T cell lymphoma (CTCL) who developed severe broadband photosensitivity. Clinical evaluation, hist...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Case Reports in Dermatological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2020/9435242 |
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| author | T. Gambichler N. Patsinakidis L. Susok M. H. Segert M. Doerler |
| author_facet | T. Gambichler N. Patsinakidis L. Susok M. H. Segert M. Doerler |
| author_sort | T. Gambichler |
| collection | DOAJ |
| description | Actinic reticuloid (AR)—a subtype of chronic actinic dermatitis—clinically and histopathologically shows lymphoma-like features. We report a male patient initially diagnosed with erythrodermic cutaneous T cell lymphoma (CTCL) who developed severe broadband photosensitivity. Clinical evaluation, histopathology, and phototesting were consistent with AR. The patient was treated with cyclosporine 150–300 mg/d. Under this therapy, he developed several times primary cutaneous anaplastic large cell lymphomas (C-ALCL) which in part tended to regress spontaneously under cyclosporine reduction. The association between cyclosporine treatment and development of C-ALCL and other CD30+ lymphoproliferative disorders has previously been reported in patients with atopic dermatitis, psoriasis, and transplant patients. In conclusion, the present case highlights the difficulties arising in the distinction between AR and CTCL and shows that long-term cyclosporine treatment may cause C-ALCL development in AR as well. |
| format | Article |
| id | doaj-art-f0d2bd8f688e43ef81a8b38d216e1aa8 |
| institution | Kabale University |
| issn | 2090-6463 2090-6471 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Dermatological Medicine |
| spelling | doaj-art-f0d2bd8f688e43ef81a8b38d216e1aa82025-02-03T05:49:55ZengWileyCase Reports in Dermatological Medicine2090-64632090-64712020-01-01202010.1155/2020/94352429435242Primary Cutaneous CD30+ Anaplastic Large T Cell Lymphoma in a Patient Treated with Cyclosporine for Actinic ReticuloidT. Gambichler0N. Patsinakidis1L. Susok2M. H. Segert3M. Doerler4Skin Cancer Center, Department of Dermatology, Ruhr-University Bochum, Bochum, GermanyDivision of Experimental Allergy and Immunodermatology, University of Oldenburg, Oldenburg, GermanySkin Cancer Center, Department of Dermatology, Ruhr-University Bochum, Bochum, GermanySkin Cancer Center, Department of Dermatology, Ruhr-University Bochum, Bochum, GermanySkin Cancer Center, Department of Dermatology, Ruhr-University Bochum, Bochum, GermanyActinic reticuloid (AR)—a subtype of chronic actinic dermatitis—clinically and histopathologically shows lymphoma-like features. We report a male patient initially diagnosed with erythrodermic cutaneous T cell lymphoma (CTCL) who developed severe broadband photosensitivity. Clinical evaluation, histopathology, and phototesting were consistent with AR. The patient was treated with cyclosporine 150–300 mg/d. Under this therapy, he developed several times primary cutaneous anaplastic large cell lymphomas (C-ALCL) which in part tended to regress spontaneously under cyclosporine reduction. The association between cyclosporine treatment and development of C-ALCL and other CD30+ lymphoproliferative disorders has previously been reported in patients with atopic dermatitis, psoriasis, and transplant patients. In conclusion, the present case highlights the difficulties arising in the distinction between AR and CTCL and shows that long-term cyclosporine treatment may cause C-ALCL development in AR as well.http://dx.doi.org/10.1155/2020/9435242 |
| spellingShingle | T. Gambichler N. Patsinakidis L. Susok M. H. Segert M. Doerler Primary Cutaneous CD30+ Anaplastic Large T Cell Lymphoma in a Patient Treated with Cyclosporine for Actinic Reticuloid Case Reports in Dermatological Medicine |
| title | Primary Cutaneous CD30+ Anaplastic Large T Cell Lymphoma in a Patient Treated with Cyclosporine for Actinic Reticuloid |
| title_full | Primary Cutaneous CD30+ Anaplastic Large T Cell Lymphoma in a Patient Treated with Cyclosporine for Actinic Reticuloid |
| title_fullStr | Primary Cutaneous CD30+ Anaplastic Large T Cell Lymphoma in a Patient Treated with Cyclosporine for Actinic Reticuloid |
| title_full_unstemmed | Primary Cutaneous CD30+ Anaplastic Large T Cell Lymphoma in a Patient Treated with Cyclosporine for Actinic Reticuloid |
| title_short | Primary Cutaneous CD30+ Anaplastic Large T Cell Lymphoma in a Patient Treated with Cyclosporine for Actinic Reticuloid |
| title_sort | primary cutaneous cd30 anaplastic large t cell lymphoma in a patient treated with cyclosporine for actinic reticuloid |
| url | http://dx.doi.org/10.1155/2020/9435242 |
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