Primary Cutaneous CD30+ Anaplastic Large T Cell Lymphoma in a Patient Treated with Cyclosporine for Actinic Reticuloid

Actinic reticuloid (AR)—a subtype of chronic actinic dermatitis—clinically and histopathologically shows lymphoma-like features. We report a male patient initially diagnosed with erythrodermic cutaneous T cell lymphoma (CTCL) who developed severe broadband photosensitivity. Clinical evaluation, hist...

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Main Authors: T. Gambichler, N. Patsinakidis, L. Susok, M. H. Segert, M. Doerler
Format: Article
Language:English
Published: Wiley 2020-01-01
Series:Case Reports in Dermatological Medicine
Online Access:http://dx.doi.org/10.1155/2020/9435242
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author T. Gambichler
N. Patsinakidis
L. Susok
M. H. Segert
M. Doerler
author_facet T. Gambichler
N. Patsinakidis
L. Susok
M. H. Segert
M. Doerler
author_sort T. Gambichler
collection DOAJ
description Actinic reticuloid (AR)—a subtype of chronic actinic dermatitis—clinically and histopathologically shows lymphoma-like features. We report a male patient initially diagnosed with erythrodermic cutaneous T cell lymphoma (CTCL) who developed severe broadband photosensitivity. Clinical evaluation, histopathology, and phototesting were consistent with AR. The patient was treated with cyclosporine 150–300 mg/d. Under this therapy, he developed several times primary cutaneous anaplastic large cell lymphomas (C-ALCL) which in part tended to regress spontaneously under cyclosporine reduction. The association between cyclosporine treatment and development of C-ALCL and other CD30+ lymphoproliferative disorders has previously been reported in patients with atopic dermatitis, psoriasis, and transplant patients. In conclusion, the present case highlights the difficulties arising in the distinction between AR and CTCL and shows that long-term cyclosporine treatment may cause C-ALCL development in AR as well.
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institution Kabale University
issn 2090-6463
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series Case Reports in Dermatological Medicine
spelling doaj-art-f0d2bd8f688e43ef81a8b38d216e1aa82025-02-03T05:49:55ZengWileyCase Reports in Dermatological Medicine2090-64632090-64712020-01-01202010.1155/2020/94352429435242Primary Cutaneous CD30+ Anaplastic Large T Cell Lymphoma in a Patient Treated with Cyclosporine for Actinic ReticuloidT. Gambichler0N. Patsinakidis1L. Susok2M. H. Segert3M. Doerler4Skin Cancer Center, Department of Dermatology, Ruhr-University Bochum, Bochum, GermanyDivision of Experimental Allergy and Immunodermatology, University of Oldenburg, Oldenburg, GermanySkin Cancer Center, Department of Dermatology, Ruhr-University Bochum, Bochum, GermanySkin Cancer Center, Department of Dermatology, Ruhr-University Bochum, Bochum, GermanySkin Cancer Center, Department of Dermatology, Ruhr-University Bochum, Bochum, GermanyActinic reticuloid (AR)—a subtype of chronic actinic dermatitis—clinically and histopathologically shows lymphoma-like features. We report a male patient initially diagnosed with erythrodermic cutaneous T cell lymphoma (CTCL) who developed severe broadband photosensitivity. Clinical evaluation, histopathology, and phototesting were consistent with AR. The patient was treated with cyclosporine 150–300 mg/d. Under this therapy, he developed several times primary cutaneous anaplastic large cell lymphomas (C-ALCL) which in part tended to regress spontaneously under cyclosporine reduction. The association between cyclosporine treatment and development of C-ALCL and other CD30+ lymphoproliferative disorders has previously been reported in patients with atopic dermatitis, psoriasis, and transplant patients. In conclusion, the present case highlights the difficulties arising in the distinction between AR and CTCL and shows that long-term cyclosporine treatment may cause C-ALCL development in AR as well.http://dx.doi.org/10.1155/2020/9435242
spellingShingle T. Gambichler
N. Patsinakidis
L. Susok
M. H. Segert
M. Doerler
Primary Cutaneous CD30+ Anaplastic Large T Cell Lymphoma in a Patient Treated with Cyclosporine for Actinic Reticuloid
Case Reports in Dermatological Medicine
title Primary Cutaneous CD30+ Anaplastic Large T Cell Lymphoma in a Patient Treated with Cyclosporine for Actinic Reticuloid
title_full Primary Cutaneous CD30+ Anaplastic Large T Cell Lymphoma in a Patient Treated with Cyclosporine for Actinic Reticuloid
title_fullStr Primary Cutaneous CD30+ Anaplastic Large T Cell Lymphoma in a Patient Treated with Cyclosporine for Actinic Reticuloid
title_full_unstemmed Primary Cutaneous CD30+ Anaplastic Large T Cell Lymphoma in a Patient Treated with Cyclosporine for Actinic Reticuloid
title_short Primary Cutaneous CD30+ Anaplastic Large T Cell Lymphoma in a Patient Treated with Cyclosporine for Actinic Reticuloid
title_sort primary cutaneous cd30 anaplastic large t cell lymphoma in a patient treated with cyclosporine for actinic reticuloid
url http://dx.doi.org/10.1155/2020/9435242
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AT npatsinakidis primarycutaneouscd30anaplasticlargetcelllymphomainapatienttreatedwithcyclosporineforactinicreticuloid
AT lsusok primarycutaneouscd30anaplasticlargetcelllymphomainapatienttreatedwithcyclosporineforactinicreticuloid
AT mhsegert primarycutaneouscd30anaplasticlargetcelllymphomainapatienttreatedwithcyclosporineforactinicreticuloid
AT mdoerler primarycutaneouscd30anaplasticlargetcelllymphomainapatienttreatedwithcyclosporineforactinicreticuloid